CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Mastr(seed) - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Mastr(seed) & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric Mastr(seed) Carnac(seed)
MCC 0.306 > 0.241
Average MCC ± 95% Confidence Intervals 0.168 ± 0.119 > 0.141 ± 0.103
Sensitivity 0.105 > 0.058
Positive Predictive Value 0.900 < 1.000
Total TP 117 > 65
Total TN 159886 < 159951
Total FP 15 > 0
Total FP CONTRA 0 = 0
Total FP INCONS 13 > 0
Total FP COMP 2 > 0
Total FN 999 < 1051
P-value 4.1569883686e-08

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Performance plots


  1. Comparison of performance of Mastr(seed) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Mastr(seed) and Carnac(seed)).

  2. Comparison of performance of Mastr(seed) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Mastr(seed) and Carnac(seed)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Mastr(seed) and Carnac(seed)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Mastr(seed) and Carnac(seed)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for Mastr(seed) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Mastr(seed) and Carnac(seed)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for Mastr(seed) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Mastr(seed) and Carnac(seed)).

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Performance of Mastr(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 117
Total TN 159886
Total FP 15
Total FP CONTRA 0
Total FP INCONS 13
Total FP COMP 2
Total FN 999
Total Scores
MCC 0.306
Average MCC ± 95% Confidence Intervals 0.168 ± 0.119
Sensitivity 0.105
Positive Predictive Value 0.900
Nr of predictions 34

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.00 0.00 0.00 0 406 0 0 0 0 11
2KE6_A 0.92 0.84 1.00 16 1112 1 0 0 1 3
2KUR_A 0.79 0.71 0.88 15 1111 2 0 2 0 6
2KUU_A 0.76 0.67 0.88 14 1112 3 0 2 1 7
2KUV_A 0.77 0.68 0.88 15 1111 2 0 2 0 7
2KUW_A 0.52 0.48 0.59 10 1111 7 0 7 0 11
2L1F_A 0.98 0.96 1.00 23 2057 0 0 0 0 1
2L1F_B 0.98 0.96 1.00 24 2121 0 0 0 0 1
2L94_A 0.00 0.00 0.00 0 990 0 0 0 0 20
2LC8_A 0.00 0.00 0.00 0 1540 0 0 0 0 20
2XKV_B 0.00 0.00 0.00 0 4560 0 0 0 0 20
2XXA_G 0.00 0.00 0.00 0 5151 0 0 0 0 42
3A3A_A 0.00 0.00 0.00 0 3655 0 0 0 0 37
3GX2_A 0.00 0.00 0.00 0 4371 0 0 0 0 40
3IVN_B 0.00 0.00 0.00 0 2346 0 0 0 0 31
3IZF_C 0.00 0.00 0.00 0 6903 0 0 0 0 54
3JYX_4 0.00 0.00 0.00 0 12246 0 0 0 0 33
3JYX_3 0.00 0.00 0.00 0 6328 0 0 0 0 27
3LA5_A 0.00 0.00 0.00 0 2485 0 0 0 0 34
3NPB_A 0.00 0.00 0.00 0 7021 0 0 0 0 46
3O58_3 0.00 0.00 0.00 0 12403 0 0 0 0 35
3O58_2 0.00 0.00 0.00 0 7260 0 0 0 0 38
3PDR_A 0.00 0.00 0.00 0 12880 0 0 0 0 72
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
3W3S_B 0.00 0.00 0.00 0 4753 0 0 0 0 40
3ZEX_C 0.00 0.00 0.00 0 14196 0 0 0 0 52
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32
4FRN_A 0.00 0.00 0.00 0 5151 0 0 0 0 36

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 65
Total TN 159951
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 1051
Total Scores
MCC 0.241
Average MCC ± 95% Confidence Intervals 0.141 ± 0.103
Sensitivity 0.058
Positive Predictive Value 1.000
Nr of predictions 34

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.00 0.00 0.00 0 1128 0 0 0 0 19
2KUR_A 0.57 0.33 1.00 7 1121 0 0 0 0 14
2KUU_A 0.57 0.33 1.00 7 1121 0 0 0 0 14
2KUV_A 0.64 0.41 1.00 9 1119 0 0 0 0 13
2KUW_A 0.65 0.43 1.00 9 1119 0 0 0 0 12
2L1F_A 0.00 0.00 0.00 0 2080 0 0 0 0 24
2L1F_B 0.00 0.00 0.00 0 2145 0 0 0 0 25
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LC8_A 0.44 0.20 1.00 4 1536 0 0 0 0 16
2XKV_B 0.00 0.00 0.00 0 4560 0 0 0 0 20
2XXA_G 0.00 0.00 0.00 0 5151 0 0 0 0 42
3A3A_A 0.00 0.00 0.00 0 3655 0 0 0 0 37
3GX2_A 0.00 0.00 0.00 0 4371 0 0 0 0 40
3IVN_B 0.00 0.00 0.00 0 2346 0 0 0 0 31
3IZF_C 0.00 0.00 0.00 0 6903 0 0 0 0 54
3JYX_4 0.00 0.00 0.00 0 12246 0 0 0 0 33
3JYX_3 0.00 0.00 0.00 0 6328 0 0 0 0 27
3LA5_A 0.00 0.00 0.00 0 2485 0 0 0 0 34
3NPB_A 0.00 0.00 0.00 0 7021 0 0 0 0 46
3O58_3 0.00 0.00 0.00 0 12403 0 0 0 0 35
3O58_2 0.00 0.00 0.00 0 7260 0 0 0 0 38
3PDR_A 0.00 0.00 0.00 0 12880 0 0 0 0 72
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
3W3S_B 0.00 0.00 0.00 0 4753 0 0 0 0 40
3ZEX_C 0.00 0.00 0.00 0 14196 0 0 0 0 52
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32
4FRN_A 0.00 0.00 0.00 0 5151 0 0 0 0 36

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.