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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MaxExpect - scored higher in this pairwise comparison

  4. Performance of MCFold - scored lower in this pairwise comparison

  5. Compile and download dataset for MaxExpect & MCFold [.zip] - may take several seconds...


Overview

Metric MaxExpect MCFold
MCC 0.629 > 0.501
Average MCC ± 95% Confidence Intervals 0.655 ± 0.059 > 0.573 ± 0.066
Sensitivity 0.559 > 0.517
Positive Predictive Value 0.713 > 0.495
Total TP 1538 > 1421
Total TN 334756 > 334040
Total FP 759 < 1674
Total FP CONTRA 66 < 185
Total FP INCONS 553 < 1267
Total FP COMP 140 < 222
Total FN 1212 < 1329
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of MaxExpect and MCFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MaxExpect and MCFold).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MaxExpect and MCFold).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MaxExpect and MCFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MaxExpect and MCFold).

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Performance of MaxExpect - scored higher in this pairwise comparison

1. Total counts & total scores for MaxExpect

Total Base Pair Counts
Total TP 1538
Total TN 334756
Total FP 759
Total FP CONTRA 66
Total FP INCONS 553
Total FP COMP 140
Total FN 1212
Total Scores
MCC 0.629
Average MCC ± 95% Confidence Intervals 0.655 ± 0.059
Sensitivity 0.559
Positive Predictive Value 0.713
Nr of predictions 113

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2. Individual counts for MaxExpect [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KE6_A 0.92 0.89 0.94 17 1110 2 0 1 1 2
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KU0_A - -0.02 0.00 0.00 0 694 9 0 9 0 16
2KUR_A 0.90 0.86 0.95 18 1109 1 0 1 0 3
2KUU_A 0.87 0.81 0.94 17 1110 2 0 1 1 4
2KUV_A 0.88 0.82 0.95 18 1109 1 0 1 0 4
2KUW_A 0.90 0.86 0.95 18 1109 1 0 1 0 3
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2KXM_A - 0.83 0.70 1.00 7 344 0 0 0 0 3
2KZL_A - 0.86 0.74 1.00 14 1471 0 0 0 0 5
2L1F_A 0.98 0.96 1.00 23 2057 0 0 0 0 1
2L1F_B 0.98 0.96 1.00 24 2121 0 0 0 0 1
2L2K_A - 0.94 0.89 1.00 17 844 0 0 0 0 2
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.94 0.88 1.00 30 2455 0 0 0 0 4
2L5Z_A - 0.86 0.75 1.00 9 316 0 0 0 0 3
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LA5_A - 0.39 0.26 0.63 5 622 3 1 2 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
2LDL_A - 0.90 0.82 1.00 9 342 1 0 0 1 2
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.81 0.74 0.88 29 6072 6 0 4 2 10
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LU0_A - 1.00 1.00 1.00 16 1160 0 0 0 0 0
2LWK_A - 0.88 0.85 0.92 11 484 1 0 1 0 2
2M58_A - -0.01 0.00 0.00 0 1640 13 0 13 0 17
2RRC_A - 0.70 0.50 1.00 5 226 0 0 0 0 5
2WRQ_Y 0.53 0.53 0.53 9 2833 13 5 3 5 8
2WW9_F - 0.69 0.70 0.70 7 290 3 0 3 0 3
2WW9_E - -0.01 0.00 0.00 0 556 5 0 5 0 14
2WW9_D - 0.14 0.12 0.19 3 1937 13 0 13 0 23
2WWQ_V 0.76 0.64 0.90 18 2906 3 0 2 1 10
2XKV_B 0.51 0.50 0.53 10 4541 24 0 9 15 10
2XQD_Y 0.88 0.78 1.00 21 2829 0 0 0 0 6
2XXA_G 0.25 0.24 0.27 10 5114 27 1 26 0 32
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.65 0.63 0.68 15 2256 8 1 6 1 9
2YIE_X - 0.36 0.33 0.40 4 1368 6 2 4 0 8
2YIE_Z - -0.01 0.00 0.00 0 1525 15 3 12 0 12
3A2K_C 0.42 0.39 0.46 11 2902 13 2 11 0 17
3AKZ_H 0.84 0.75 0.95 21 2679 1 1 0 0 7
3AM1_B - 0.78 0.71 0.86 25 3211 4 0 4 0 10
3AMU_B 0.64 0.59 0.70 16 2980 9 0 7 2 11
3GX2_A 0.77 0.63 0.96 25 4345 2 0 1 1 15
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IWN_A 0.74 0.67 0.81 22 4251 6 0 5 1 11
3IZF_C 0.71 0.61 0.83 33 6863 7 1 6 0 21
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_2 - 0.25 0.24 0.26 8 6185 25 2 21 2 25
3J0L_7 - -0.01 0.00 0.00 0 1213 12 0 12 0 17
3J0L_h - 0.81 0.65 1.00 28 6077 2 0 0 2 15
3J0L_1 - 0.76 0.63 0.92 12 1212 2 0 1 1 7
3J0L_a - 0.39 0.31 0.50 5 1118 5 2 3 0 11
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J16_L 0.29 0.23 0.37 7 2756 12 0 12 0 23
3J20_0 0.44 0.40 0.50 12 2826 13 0 12 1 18
3J2L_3 0.62 0.53 0.74 28 7837 12 0 10 2 25
3J3D_C 0.47 0.43 0.52 12 2752 11 1 10 0 16
3J3E_8 0.07 0.06 0.08 2 7478 32 2 21 9 31
3J3E_7 0.46 0.37 0.59 20 7106 14 1 13 0 34
3J3F_8 0.32 0.31 0.33 11 12213 36 3 19 14 25
3J3F_7 0.79 0.68 0.92 34 7223 4 0 3 1 16
3JYV_7 0.41 0.31 0.56 10 2832 8 0 8 0 22
3JYX_3 0.64 0.63 0.65 17 6302 19 1 8 10 10
3JYX_4 0.31 0.30 0.31 10 12214 34 4 18 12 23
3KTW_C - 0.54 0.47 0.65 20 4529 12 2 9 1 23
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.78 0.69 0.89 42 9133 6 0 5 1 19
3NKB_B - 0.59 0.54 0.67 14 1995 7 0 7 0 12
3NMU_E - -0.01 0.00 0.00 0 553 10 1 7 2 6
3O58_3 0.35 0.34 0.35 12 12369 35 2 20 13 23
3O58_2 0.75 0.76 0.74 29 7221 11 3 7 1 9
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.76 0.63 0.94 45 12832 5 0 3 2 27
3R4F_A - 0.96 0.92 1.00 23 2122 0 0 0 0 2
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.58 0.48 0.71 20 3888 8 1 7 0 22
3SIU_F - 0.85 0.73 1.00 8 370 0 0 0 0 3
3SN2_B 1.00 1.00 1.00 12 394 0 0 0 0 0
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.45 0.35 0.59 13 3138 9 1 8 0 24
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3ZEX_G - 0.77 0.66 0.91 49 16417 11 0 5 6 25
3ZEX_D 0.69 0.61 0.79 30 6983 8 1 7 0 19
3ZEX_H - 0.19 0.18 0.19 7 9009 29 5 24 0 31
3ZEX_C 0.41 0.27 0.64 14 14174 16 2 6 8 38
3ZEX_F - 0.00 0.00 0.00 0 2617 11 2 9 0 12
3ZND_W 0.20 0.22 0.19 5 2977 23 1 20 2 18
4A1C_2 0.14 0.15 0.14 5 11746 41 4 26 11 28
4A1C_3 0.69 0.57 0.84 31 7103 6 0 6 0 23
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4ATO_G - 0.38 0.30 0.50 3 522 3 0 3 0 7
4ENB_A 0.76 0.58 1.00 11 1264 0 0 0 0 8
4ENC_A 0.31 0.26 0.38 5 1313 8 1 7 0 14
4FNJ_A - 0.79 0.63 1.00 10 585 0 0 0 0 6
4FRG_B 0.30 0.22 0.41 7 3469 10 1 9 0 25
4FRN_A 0.45 0.36 0.57 13 5128 10 2 8 0 23
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0
4JF2_A 0.78 0.61 1.00 19 2831 0 0 0 0 12
4JRC_A - 0.29 0.26 0.35 6 1523 11 0 11 0 17

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Performance of MCFold - scored lower in this pairwise comparison

1. Total counts & total scores for MCFold

Total Base Pair Counts
Total TP 1421
Total TN 334040
Total FP 1674
Total FP CONTRA 185
Total FP INCONS 1267
Total FP COMP 222
Total FN 1329
Total Scores
MCC 0.501
Average MCC ± 95% Confidence Intervals 0.573 ± 0.066
Sensitivity 0.517
Positive Predictive Value 0.495
Nr of predictions 113

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2. Individual counts for MCFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KD8_A - 1.00 1.00 1.00 9 222 1 0 0 1 0
2KE6_A 1.00 1.00 1.00 19 1109 2 0 0 2 0
2KPV_A - 1.00 1.00 1.00 13 548 2 0 0 2 0
2KU0_A - 0.97 0.94 1.00 15 688 0 0 0 0 1
2KUR_A 1.00 1.00 1.00 21 1107 0 0 0 0 0
2KUU_A 0.98 0.95 1.00 20 1108 1 0 0 1 1
2KUV_A 0.98 0.95 1.00 21 1107 0 0 0 0 1
2KUW_A 0.95 0.95 0.95 20 1107 1 0 1 0 1
2KX8_A 0.91 0.89 0.94 16 844 2 0 1 1 2
2KXM_A - 1.00 1.00 1.00 10 341 1 0 0 1 0
2KZL_A - 0.80 0.84 0.76 16 1464 9 1 4 4 3
2L1F_A 0.72 0.75 0.69 18 2054 9 0 8 1 6
2L1F_B 0.73 0.76 0.70 19 2118 9 0 8 1 6
2L2K_A - 1.00 1.00 1.00 19 842 1 0 0 1 0
2L3C_B - 0.97 0.94 1.00 16 545 0 0 0 0 1
2L3E_A - 1.00 1.00 1.00 13 582 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 34 2451 0 0 0 0 0
2L5Z_A - 0.96 0.92 1.00 11 314 0 0 0 0 1
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LA5_A - -0.03 0.00 0.00 0 615 15 0 15 0 19
2LBS_A - 1.00 1.00 1.00 14 482 1 0 0 1 0
2LC8_A 0.41 0.45 0.39 9 1517 16 0 14 2 11
2LDL_A - 0.95 0.91 1.00 10 341 2 0 0 2 1
2LDT_A - 0.75 0.73 0.79 11 451 3 0 3 0 4
2LHP_A - 1.00 1.00 1.00 16 650 1 0 0 1 0
2LI4_A - 0.97 0.94 1.00 15 481 0 0 0 0 1
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 1.00 1.00 1.00 10 266 0 0 0 0 0
2LKR_A - 0.93 0.92 0.95 36 6067 14 0 2 12 3
2LQZ_A - 0.91 0.91 0.91 10 340 1 1 0 0 1
2LU0_A - 1.00 1.00 1.00 16 1160 5 0 0 5 0
2LWK_A - 0.92 0.92 0.92 12 483 2 0 1 1 1
2M58_A - 0.20 0.24 0.18 4 1631 19 2 16 1 13
2RRC_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2WRQ_Y 0.27 0.35 0.22 6 2823 25 8 13 4 11
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WW9_E - -0.02 0.00 0.00 0 547 14 0 14 0 14
2WW9_D - -0.01 0.00 0.00 0 1925 28 5 23 0 26
2WWQ_V 0.15 0.18 0.15 5 2892 30 4 25 1 23
2XKV_B 0.20 0.25 0.17 5 4530 37 2 23 12 15
2XQD_Y 0.34 0.37 0.32 10 2819 22 1 20 1 17
2XXA_G 0.23 0.24 0.24 10 5110 32 1 30 1 32
2Y8W_B - 1.00 1.00 1.00 6 184 2 0 0 2 0
2Y9C_V - 0.62 0.67 0.59 16 2251 13 2 9 2 8
2YIE_X - 0.06 0.08 0.06 1 1361 21 1 15 5 11
2YIE_Z - 0.36 0.50 0.27 6 1518 18 4 12 2 6
3A2K_C 0.44 0.46 0.42 13 2895 18 2 16 0 15
3AKZ_H 0.40 0.43 0.39 12 2670 19 3 16 0 16
3AM1_B - 0.93 0.89 0.97 31 3208 2 0 1 1 4
3AMU_B 0.44 0.48 0.42 13 2972 18 2 16 0 14
3GX2_A 0.47 0.48 0.48 19 4331 22 0 21 1 21
3IAB_R - 0.84 0.93 0.76 13 1018 8 2 2 4 1
3IVN_B 0.39 0.39 0.40 12 2316 18 0 18 0 19
3IWN_A 0.19 0.21 0.18 7 4238 33 8 25 0 26
3IZF_C 0.71 0.69 0.74 37 6853 14 0 13 1 17
3J0L_g - 0.13 0.25 0.08 1 452 12 8 4 0 3
3J0L_2 - 0.21 0.24 0.18 8 6172 39 7 29 3 25
3J0L_7 - -0.01 0.00 0.00 0 1206 19 4 15 0 17
3J0L_h - 0.91 0.91 0.91 39 6062 13 0 4 9 4
3J0L_1 - 0.79 0.79 0.79 15 1206 6 0 4 2 4
3J0L_a - 0.16 0.19 0.17 3 1110 15 1 14 0 13
3J0L_8 - 1.00 1.00 1.00 8 182 0 0 0 0 0
3J16_L 0.45 0.47 0.44 14 2743 19 1 17 1 16
3J20_0 0.59 0.57 0.63 17 2823 12 1 9 2 13
3J2L_3 0.58 0.57 0.60 30 7825 23 2 18 3 23
3J3D_C 0.42 0.43 0.43 12 2747 18 2 14 2 16
3J3E_8 0.12 0.12 0.12 4 7470 46 3 26 17 29
3J3E_7 0.40 0.39 0.42 21 7090 29 3 26 0 33
3J3F_8 0.13 0.17 0.11 6 12191 61 9 40 12 30
3J3F_7 0.74 0.74 0.74 37 7210 17 2 11 4 13
3JYV_7 0.21 0.22 0.21 7 2817 26 0 26 0 25
3JYX_3 0.41 0.52 0.33 14 6285 34 12 17 5 13
3JYX_4 0.20 0.24 0.17 8 12199 43 16 23 4 25
3KTW_C - 0.40 0.40 0.43 17 4520 24 4 19 1 26
3LA5_A 0.32 0.32 0.34 11 2453 21 1 20 0 23
3NDB_M - 0.23 0.23 0.24 14 9121 46 1 44 1 47
3NKB_B - 0.56 0.58 0.56 15 1989 13 0 12 1 11
3NMU_E - 0.28 0.33 0.25 2 553 12 0 6 6 4
3O58_3 0.22 0.26 0.19 9 12355 45 9 30 6 26
3O58_2 0.20 0.24 0.17 9 7208 44 5 38 1 29
3OVB_D - 1.00 1.00 1.00 11 584 2 0 0 2 0
3OVS_D - 1.00 1.00 1.00 13 548 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 12 729 5 0 0 5 0
3PDR_A 0.66 0.61 0.72 44 12819 19 0 17 2 28
3R4F_A - 0.92 0.92 0.92 23 2120 5 0 2 3 2
3R9X_C - 0.69 0.70 0.70 7 585 7 0 3 4 3
3RKF_A 0.70 0.65 0.76 22 2182 7 1 6 0 12
3SD1_A 0.33 0.33 0.35 14 3876 26 0 26 0 28
3SIU_F - 0.42 0.45 0.42 5 366 7 1 6 0 6
3SN2_B 0.55 0.58 0.54 7 393 6 0 6 0 5
3TRZ_Z - -0.04 0.00 0.00 0 201 9 0 9 0 6
3TS0_U - 1.00 1.00 1.00 6 247 2 0 0 2 0
3TS2_V - -0.02 0.00 0.00 0 268 9 0 8 1 5
3U4M_B - 0.59 0.59 0.59 22 3123 15 0 15 0 15
3VJR_D - 1.00 1.00 1.00 13 617 1 0 0 1 0
3ZEX_G - 0.00 0.00 0.00 0 16456 15 1 14 0 74
3ZEX_D 0.17 0.18 0.18 9 6970 42 4 38 0 40
3ZEX_H - 0.14 0.18 0.12 7 8987 52 14 37 1 31
3ZEX_C 0.24 0.21 0.28 11 14156 29 3 26 0 41
3ZEX_F - -0.01 0.00 0.00 0 2610 29 4 14 11 12
3ZND_W 0.19 0.22 0.18 5 2975 26 1 22 3 18
4A1C_2 0.13 0.15 0.11 5 11735 56 10 31 15 28
4A1C_3 0.68 0.67 0.71 36 7089 17 1 14 2 18
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4ATO_G - 0.30 0.30 0.33 3 519 8 0 6 2 7
4ENB_A 0.61 0.63 0.60 12 1255 8 2 6 0 7
4ENC_A 0.28 0.32 0.27 6 1304 17 2 14 1 13
4FNJ_A - 0.83 0.81 0.87 13 580 3 0 2 1 3
4FRG_B 0.32 0.34 0.31 11 3450 25 0 25 0 21
4FRN_A 0.12 0.14 0.12 5 5110 38 1 35 2 31
4HXH_A - 1.00 1.00 1.00 6 319 4 0 0 4 0
4JF2_A 0.66 0.68 0.66 21 2818 11 0 11 0 10
4JRC_A - 0.20 0.22 0.21 5 1516 19 0 19 0 18

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.