CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MaxExpect - scored higher in this pairwise comparison

  4. Performance of PknotsRG - scored lower in this pairwise comparison

  5. Compile and download dataset for MaxExpect & PknotsRG [.zip] - may take several seconds...


Overview

Metric MaxExpect PknotsRG
MCC 0.559 > 0.517
Average MCC ± 95% Confidence Intervals 0.662 ± 0.055 < 0.671 ± 0.051
Sensitivity 0.486 > 0.459
Positive Predictive Value 0.645 > 0.583
Total TP 2466 > 2329
Total TN 5714765 > 5714591
Total FP 1517 < 1817
Total FP CONTRA 146 < 177
Total FP INCONS 1210 < 1490
Total FP COMP 161 > 150
Total FN 2611 < 2748
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of MaxExpect and PknotsRG. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MaxExpect and PknotsRG).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MaxExpect and PknotsRG).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MaxExpect and PknotsRG. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MaxExpect and PknotsRG).

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Performance of MaxExpect - scored higher in this pairwise comparison

1. Total counts & total scores for MaxExpect

Total Base Pair Counts
Total TP 2466
Total TN 5714765
Total FP 1517
Total FP CONTRA 146
Total FP INCONS 1210
Total FP COMP 161
Total FN 2611
Total Scores
MCC 0.559
Average MCC ± 95% Confidence Intervals 0.662 ± 0.055
Sensitivity 0.486
Positive Predictive Value 0.645
Nr of predictions 117

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2. Individual counts for MaxExpect [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KE6_A 0.92 0.89 0.94 17 1110 2 0 1 1 2
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.76 0.60 0.96 24 5126 5 0 1 4 16
2KU0_A - -0.02 0.00 0.00 0 694 9 0 9 0 16
2KUR_A 0.90 0.86 0.95 18 1109 1 0 1 0 3
2KUU_A 0.87 0.81 0.94 17 1110 2 0 1 1 4
2KUV_A 0.88 0.82 0.95 18 1109 1 0 1 0 4
2KUW_A 0.90 0.86 0.95 18 1109 1 0 1 0 3
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2KXM_A - 0.83 0.70 1.00 7 344 0 0 0 0 3
2KZL_A - 0.86 0.74 1.00 14 1471 0 0 0 0 5
2L1F_B 0.98 0.96 1.00 24 2121 0 0 0 0 1
2L1F_A 0.98 0.96 1.00 23 2057 0 0 0 0 1
2L2K_A - 0.94 0.89 1.00 17 844 0 0 0 0 2
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.94 0.88 1.00 30 2455 0 0 0 0 4
2L5Z_A - 0.86 0.75 1.00 9 316 0 0 0 0 3
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LA5_A - 0.39 0.26 0.63 5 622 3 1 2 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
2LDL_A - 0.90 0.82 1.00 9 342 1 0 0 1 2
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.81 0.74 0.88 29 6072 6 0 4 2 10
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LWK_A - 0.88 0.85 0.92 11 484 1 0 1 0 2
2RRC_A - 0.70 0.50 1.00 5 226 0 0 0 0 5
2WRQ_Y 0.53 0.53 0.53 9 2833 13 5 3 5 8
2WW9_F - 0.69 0.70 0.70 7 290 3 0 3 0 3
2WW9_E - -0.01 0.00 0.00 0 556 5 0 5 0 14
2WW9_D - 0.14 0.12 0.19 3 1937 13 0 13 0 23
2WWQ_V 0.76 0.64 0.90 18 2906 3 0 2 1 10
2XKV_B 0.51 0.50 0.53 10 4541 24 0 9 15 10
2XQD_Y 0.88 0.78 1.00 21 2829 0 0 0 0 6
2XXA_G 0.25 0.24 0.27 10 5114 27 1 26 0 32
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.65 0.63 0.68 15 2256 8 1 6 1 9
2YIE_X - 0.36 0.33 0.40 4 1368 6 2 4 0 8
2YIE_Z - -0.01 0.00 0.00 0 1525 15 3 12 0 12
3A2K_C 0.42 0.39 0.46 11 2902 13 2 11 0 17
3ADB_C - 0.80 0.74 0.88 28 4154 4 0 4 0 10
3AKZ_H 0.84 0.75 0.95 21 2679 1 1 0 0 7
3AM1_B - 0.78 0.71 0.86 25 3211 4 0 4 0 10
3AMU_B 0.64 0.59 0.70 16 2980 9 0 7 2 11
3GX2_A 0.77 0.63 0.96 25 4345 2 0 1 1 15
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IWN_A 0.74 0.67 0.81 22 4251 6 0 5 1 11
3IYQ_A 0.29 0.31 0.27 29 60617 84 19 61 4 65
3IZ4_A 0.54 0.46 0.64 61 70781 39 3 31 5 71
3IZF_C 0.71 0.61 0.83 33 6863 7 1 6 0 21
3J0L_7 - -0.01 0.00 0.00 0 1213 12 0 12 0 17
3J0L_h - 0.81 0.65 1.00 28 6077 2 0 0 2 15
3J0L_1 - 0.76 0.63 0.92 12 1212 2 0 1 1 7
3J0L_a - 0.39 0.31 0.50 5 1118 5 2 3 0 11
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_2 - 0.25 0.24 0.26 8 6185 25 2 21 2 25
3J16_L 0.29 0.23 0.37 7 2756 12 0 12 0 23
3J20_0 0.44 0.40 0.50 12 2826 13 0 12 1 18
3J20_1 0.73 0.70 0.76 16 2905 5 0 5 0 7
3J2C_O - 0.63 0.51 0.78 32 10255 10 0 9 1 31
3J2C_M - 0.38 0.31 0.47 64 106354 76 10 63 3 143
3J2L_3 0.62 0.53 0.74 28 7837 12 0 10 2 25
3JYV_7 0.41 0.31 0.56 10 2832 8 0 8 0 22
3JYX_3 0.64 0.63 0.65 17 6302 19 1 8 10 10
3JYX_4 0.31 0.30 0.31 10 12214 34 4 18 12 23
3KIY_A - 0.54 0.45 0.65 553 4053271 314 23 281 10 688
3KTW_C - 0.54 0.47 0.65 20 4529 12 2 9 1 23
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.78 0.69 0.89 42 9133 6 0 5 1 19
3NKB_B - 0.59 0.54 0.67 14 1995 7 0 7 0 12
3NMU_E - -0.01 0.00 0.00 0 553 10 1 7 2 6
3NPB_A 0.71 0.61 0.82 28 6987 9 0 6 3 18
3O58_3 0.35 0.34 0.35 12 12369 35 2 20 13 23
3O58_2 0.75 0.76 0.74 29 7221 11 3 7 1 9
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.76 0.63 0.94 45 12832 5 0 3 2 27
3R4F_A - 0.96 0.92 1.00 23 2122 0 0 0 0 2
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.58 0.48 0.71 20 3888 8 1 7 0 22
3SIU_F - 0.85 0.73 1.00 8 370 0 0 0 0 3
3SN2_B 1.00 1.00 1.00 12 394 0 0 0 0 0
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.45 0.35 0.59 13 3138 9 1 8 0 24
3UZL_B 0.77 0.62 0.96 23 3546 1 0 1 0 14
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.88 0.78 1.00 31 4722 1 0 0 1 9
3ZEX_G - 0.77 0.66 0.91 49 16417 11 0 5 6 25
3ZEX_C 0.41 0.27 0.64 14 14174 16 2 6 8 38
3ZEX_H - 0.19 0.18 0.19 7 9009 29 5 24 0 31
3ZEX_F - 0.00 0.00 0.00 0 2617 11 2 9 0 12
3ZEX_D 0.69 0.61 0.79 30 6983 8 1 7 0 19
3ZEX_E - 0.00 0.00 0.00 0 21893 54 2 50 2 77
3ZEX_B - 0.30 0.26 0.35 147 1071957 289 29 247 13 411
4A1C_2 0.14 0.15 0.14 5 11746 41 4 26 11 28
4A1C_3 0.69 0.57 0.84 31 7103 6 0 6 0 23
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.50 0.40 0.63 17 4344 11 2 8 1 25
4ATO_G - 0.38 0.30 0.50 3 522 3 0 3 0 7
4ENB_A 0.76 0.58 1.00 11 1264 0 0 0 0 8
4ENC_A 0.31 0.26 0.38 5 1313 8 1 7 0 14
4FNJ_A - 0.79 0.63 1.00 10 585 0 0 0 0 6
4FRG_B 0.30 0.22 0.41 7 3469 10 1 9 0 25
4FRN_A 0.45 0.36 0.57 13 5128 10 2 8 0 23
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0

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Performance of PknotsRG - scored lower in this pairwise comparison

1. Total counts & total scores for PknotsRG

Total Base Pair Counts
Total TP 2329
Total TN 5714591
Total FP 1817
Total FP CONTRA 177
Total FP INCONS 1490
Total FP COMP 150
Total FN 2748
Total Scores
MCC 0.517
Average MCC ± 95% Confidence Intervals 0.671 ± 0.051
Sensitivity 0.459
Positive Predictive Value 0.583
Nr of predictions 117

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2. Individual counts for PknotsRG [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KE6_A 0.86 0.84 0.89 16 1110 3 0 2 1 3
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.72 0.60 0.86 24 5123 8 2 2 4 16
2KU0_A - 0.83 0.69 1.00 11 692 0 0 0 0 5
2KUR_A 0.85 0.81 0.89 17 1109 2 0 2 0 4
2KUU_A 0.82 0.76 0.89 16 1110 3 0 2 1 5
2KUV_A 0.83 0.77 0.89 17 1109 2 0 2 0 5
2KUW_A 0.90 0.86 0.95 18 1109 1 0 1 0 3
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2KXM_A - 0.83 0.70 1.00 7 344 0 0 0 0 3
2KZL_A - 0.86 0.74 1.00 14 1471 0 0 0 0 5
2L1F_B 0.98 0.96 1.00 24 2121 0 0 0 0 1
2L1F_A 0.98 0.96 1.00 23 2057 0 0 0 0 1
2L2K_A - 0.94 0.89 1.00 17 844 0 0 0 0 2
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.94 0.88 1.00 30 2455 0 0 0 0 4
2L5Z_A - 0.86 0.75 1.00 9 316 0 0 0 0 3
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LA5_A - 0.39 0.26 0.63 5 622 3 1 2 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A 0.63 0.55 0.73 11 1525 4 1 3 0 9
2LDL_A - 0.90 0.82 1.00 9 342 1 0 0 1 2
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.73 0.69 0.77 27 6070 8 2 6 0 12
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LWK_A - 0.83 0.77 0.91 10 485 1 0 1 0 3
2RRC_A - 0.70 0.50 1.00 5 226 0 0 0 0 5
2WRQ_Y 0.53 0.53 0.53 9 2833 13 5 3 5 8
2WW9_F - 0.69 0.70 0.70 7 290 3 0 3 0 3
2WW9_E - 0.53 0.29 1.00 4 557 0 0 0 0 10
2WW9_D - 0.14 0.12 0.19 3 1937 13 0 13 0 23
2WWQ_V 0.76 0.68 0.86 19 2904 5 0 3 2 9
2XKV_B 0.51 0.50 0.53 10 4541 22 0 9 13 10
2XQD_Y 0.88 0.78 1.00 21 2829 0 0 0 0 6
2XXA_G 0.34 0.31 0.39 13 5118 20 1 19 0 29
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.66 0.63 0.71 15 2257 8 1 5 2 9
2YIE_X - 0.30 0.33 0.29 4 1364 10 2 8 0 8
2YIE_Z - -0.01 0.00 0.00 0 1525 15 3 12 0 12
3A2K_C 0.42 0.39 0.46 11 2902 13 2 11 0 17
3ADB_C - 0.33 0.32 0.36 12 4153 21 0 21 0 26
3AKZ_H 0.41 0.39 0.44 11 2676 14 4 10 0 17
3AM1_B - 0.68 0.63 0.73 22 3210 8 1 7 0 13
3AMU_B 0.70 0.59 0.84 16 2984 5 0 3 2 11
3GX2_A 0.67 0.55 0.81 22 4344 6 0 5 1 18
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IWN_A 0.20 0.18 0.24 6 4253 19 1 18 0 27
3IYQ_A 0.31 0.33 0.28 31 60617 80 24 54 2 63
3IZ4_A 0.51 0.47 0.55 62 70763 52 10 41 1 70
3IZF_C 0.59 0.52 0.67 28 6861 14 1 13 0 26
3J0L_7 - 0.28 0.29 0.29 5 1208 12 0 12 0 12
3J0L_h - 0.75 0.60 0.93 26 6077 4 0 2 2 17
3J0L_1 - 0.76 0.63 0.92 12 1212 2 0 1 1 7
3J0L_a - 0.23 0.19 0.30 3 1118 7 1 6 0 13
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_2 - 0.24 0.24 0.24 8 6183 27 2 23 2 25
3J16_L 0.75 0.57 1.00 17 2758 0 0 0 0 13
3J20_0 0.43 0.40 0.48 12 2825 14 0 13 1 18
3J20_1 0.96 0.91 1.00 21 2905 0 0 0 0 2
3J2C_O - 0.60 0.51 0.71 32 10251 14 0 13 1 31
3J2C_M - 0.50 0.41 0.61 85 106351 58 9 46 3 122
3J2L_3 0.62 0.53 0.74 28 7837 12 0 10 2 25
3JYV_7 -0.01 0.00 0.00 0 2828 22 1 21 0 32
3JYX_3 0.62 0.63 0.61 17 6300 22 1 10 11 10
3JYX_4 0.31 0.30 0.32 10 12215 33 5 16 12 23
3KIY_A - 0.39 0.33 0.45 413 4053217 505 24 474 7 828
3KTW_C - 0.77 0.65 0.90 28 4529 4 2 1 1 15
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.77 0.69 0.86 42 9131 8 0 7 1 19
3NKB_B - 0.59 0.54 0.67 14 1995 7 0 7 0 12
3NMU_E - 0.54 0.50 0.60 3 556 5 0 2 3 3
3NPB_A 0.83 0.72 0.97 33 6987 3 0 1 2 13
3O58_3 0.34 0.34 0.34 12 12368 34 2 21 11 23
3O58_2 0.59 0.61 0.58 23 7220 19 4 13 2 15
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.75 0.63 0.90 45 12830 7 1 4 2 27
3R4F_A - 0.96 0.92 1.00 23 2122 0 0 0 0 2
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.61 0.50 0.75 21 3888 7 1 6 0 21
3SIU_F - 0.85 0.73 1.00 8 370 0 0 0 0 3
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.38 0.32 0.46 12 3134 14 0 14 0 25
3UZL_B 0.48 0.38 0.61 14 3547 9 0 9 0 23
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.58 0.53 0.66 21 4721 12 1 10 1 19
3ZEX_G - 0.56 0.46 0.68 34 16421 21 1 15 5 40
3ZEX_C 0.24 0.21 0.28 11 14157 43 1 27 15 41
3ZEX_H - 0.18 0.18 0.18 7 9006 32 6 26 0 31
3ZEX_F - 0.00 0.00 0.00 0 2617 11 2 9 0 12
3ZEX_D 0.77 0.65 0.91 32 6986 3 0 3 0 17
3ZEX_E - 0.00 0.00 0.00 0 21892 55 4 49 2 77
3ZEX_B - 0.30 0.27 0.34 152 1071927 311 34 267 10 406
4A1C_2 0.14 0.15 0.13 5 11742 43 5 29 9 28
4A1C_3 0.70 0.59 0.82 32 7101 7 1 6 0 22
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.50 0.40 0.63 17 4344 11 2 8 1 25
4ATO_G - 0.73 0.70 0.78 7 519 2 1 1 0 3
4ENB_A 0.89 0.79 1.00 15 1260 0 0 0 0 4
4ENC_A 0.86 0.79 0.94 15 1310 1 1 0 0 4
4FNJ_A - 0.79 0.63 1.00 10 585 0 0 0 0 6
4FRG_B 0.32 0.28 0.38 9 3462 15 0 15 0 23
4FRN_A 0.52 0.44 0.62 16 5125 10 2 8 0 20
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.