CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MaxExpect - scored higher in this pairwise comparison

  4. Performance of RNAsubopt - scored lower in this pairwise comparison

  5. Compile and download dataset for MaxExpect & RNAsubopt [.zip] - may take several seconds...


Overview

Metric MaxExpect RNAsubopt
MCC 0.610 > 0.595
Average MCC ± 95% Confidence Intervals 0.666 ± 0.056 > 0.665 ± 0.055
Sensitivity 0.539 > 0.536
Positive Predictive Value 0.695 > 0.664
Total TP 1766 > 1756
Total TN 589537 > 589436
Total FP 914 < 1019
Total FP CONTRA 94 < 117
Total FP INCONS 682 < 770
Total FP COMP 138 > 132
Total FN 1512 < 1522
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of MaxExpect and RNAsubopt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MaxExpect and RNAsubopt).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MaxExpect and RNAsubopt).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MaxExpect and RNAsubopt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MaxExpect and RNAsubopt).

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Performance of MaxExpect - scored higher in this pairwise comparison

1. Total counts & total scores for MaxExpect

Total Base Pair Counts
Total TP 1766
Total TN 589537
Total FP 914
Total FP CONTRA 94
Total FP INCONS 682
Total FP COMP 138
Total FN 1512
Total Scores
MCC 0.610
Average MCC ± 95% Confidence Intervals 0.666 ± 0.056
Sensitivity 0.539
Positive Predictive Value 0.695
Nr of predictions 115

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2. Individual counts for MaxExpect [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KE6_A 0.92 0.89 0.94 17 1110 2 0 1 1 2
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.76 0.60 0.96 24 5126 5 0 1 4 16
2KU0_A - -0.02 0.00 0.00 0 694 9 0 9 0 16
2KUR_A 0.90 0.86 0.95 18 1109 1 0 1 0 3
2KUU_A 0.87 0.81 0.94 17 1110 2 0 1 1 4
2KUV_A 0.88 0.82 0.95 18 1109 1 0 1 0 4
2KUW_A 0.90 0.86 0.95 18 1109 1 0 1 0 3
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2KXM_A - 0.83 0.70 1.00 7 344 0 0 0 0 3
2KZL_A - 0.86 0.74 1.00 14 1471 0 0 0 0 5
2L1F_A 0.98 0.96 1.00 23 2057 0 0 0 0 1
2L1F_B 0.98 0.96 1.00 24 2121 0 0 0 0 1
2L2K_A - 0.94 0.89 1.00 17 844 0 0 0 0 2
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.94 0.88 1.00 30 2455 0 0 0 0 4
2L5Z_A - 0.86 0.75 1.00 9 316 0 0 0 0 3
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LA5_A - 0.39 0.26 0.63 5 622 3 1 2 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
2LDL_A - 0.90 0.82 1.00 9 342 1 0 0 1 2
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.81 0.74 0.88 29 6072 6 0 4 2 10
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LWK_A - 0.88 0.85 0.92 11 484 1 0 1 0 2
2RRC_A - 0.70 0.50 1.00 5 226 0 0 0 0 5
2WRQ_Y 0.53 0.53 0.53 9 2833 13 5 3 5 8
2WW9_D - 0.14 0.12 0.19 3 1937 13 0 13 0 23
2WW9_E - -0.01 0.00 0.00 0 556 5 0 5 0 14
2WW9_F - 0.69 0.70 0.70 7 290 3 0 3 0 3
2WWQ_V 0.76 0.64 0.90 18 2906 3 0 2 1 10
2XKV_B 0.51 0.50 0.53 10 4541 24 0 9 15 10
2XQD_Y 0.88 0.78 1.00 21 2829 0 0 0 0 6
2XXA_G 0.25 0.24 0.27 10 5114 27 1 26 0 32
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.65 0.63 0.68 15 2256 8 1 6 1 9
2YIE_X - 0.36 0.33 0.40 4 1368 6 2 4 0 8
2YIE_Z - -0.01 0.00 0.00 0 1525 15 3 12 0 12
3A2K_C 0.42 0.39 0.46 11 2902 13 2 11 0 17
3ADB_C - 0.80 0.74 0.88 28 4154 4 0 4 0 10
3AKZ_H 0.84 0.75 0.95 21 2679 1 1 0 0 7
3AM1_B - 0.78 0.71 0.86 25 3211 4 0 4 0 10
3AMU_B 0.64 0.59 0.70 16 2980 9 0 7 2 11
3GX2_A 0.77 0.63 0.96 25 4345 2 0 1 1 15
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IWN_A 0.74 0.67 0.81 22 4251 6 0 5 1 11
3IYQ_A 0.29 0.31 0.27 29 60617 84 19 61 4 65
3IZ4_A 0.54 0.46 0.64 61 70781 39 3 31 5 71
3IZF_C 0.71 0.61 0.83 33 6863 7 1 6 0 21
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_7 - -0.01 0.00 0.00 0 1213 12 0 12 0 17
3J0L_h - 0.81 0.65 1.00 28 6077 2 0 0 2 15
3J0L_1 - 0.76 0.63 0.92 12 1212 2 0 1 1 7
3J0L_a - 0.39 0.31 0.50 5 1118 5 2 3 0 11
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_2 - 0.25 0.24 0.26 8 6185 25 2 21 2 25
3J16_L 0.29 0.23 0.37 7 2756 12 0 12 0 23
3J20_0 0.44 0.40 0.50 12 2826 13 0 12 1 18
3J20_1 0.73 0.70 0.76 16 2905 5 0 5 0 7
3J2C_O - 0.63 0.51 0.78 32 10255 10 0 9 1 31
3J2C_M - 0.38 0.31 0.47 64 106354 76 10 63 3 143
3J2L_3 0.62 0.53 0.74 28 7837 12 0 10 2 25
3JYV_7 0.41 0.31 0.56 10 2832 8 0 8 0 22
3JYX_4 0.31 0.30 0.31 10 12214 34 4 18 12 23
3JYX_3 0.64 0.63 0.65 17 6302 19 1 8 10 10
3KTW_C - 0.54 0.47 0.65 20 4529 12 2 9 1 23
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.78 0.69 0.89 42 9133 6 0 5 1 19
3NKB_B - 0.59 0.54 0.67 14 1995 7 0 7 0 12
3NMU_E - -0.01 0.00 0.00 0 553 10 1 7 2 6
3NPB_A 0.71 0.61 0.82 28 6987 9 0 6 3 18
3O58_2 0.75 0.76 0.74 29 7221 11 3 7 1 9
3O58_3 0.35 0.34 0.35 12 12369 35 2 20 13 23
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.76 0.63 0.94 45 12832 5 0 3 2 27
3R4F_A - 0.96 0.92 1.00 23 2122 0 0 0 0 2
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.58 0.48 0.71 20 3888 8 1 7 0 22
3SIU_F - 0.85 0.73 1.00 8 370 0 0 0 0 3
3SN2_B 1.00 1.00 1.00 12 394 0 0 0 0 0
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.45 0.35 0.59 13 3138 9 1 8 0 24
3UZL_B 0.77 0.62 0.96 23 3546 1 0 1 0 14
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.88 0.78 1.00 31 4722 1 0 0 1 9
3ZEX_F - 0.00 0.00 0.00 0 2617 11 2 9 0 12
3ZEX_C 0.41 0.27 0.64 14 14174 16 2 6 8 38
3ZEX_G - 0.77 0.66 0.91 49 16417 11 0 5 6 25
3ZEX_D 0.69 0.61 0.79 30 6983 8 1 7 0 19
3ZEX_E - 0.00 0.00 0.00 0 21893 54 2 50 2 77
3ZEX_H - 0.19 0.18 0.19 7 9009 29 5 24 0 31
4A1C_2 0.14 0.15 0.14 5 11746 41 4 26 11 28
4A1C_3 0.69 0.57 0.84 31 7103 6 0 6 0 23
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.50 0.40 0.63 17 4344 11 2 8 1 25
4ATO_G - 0.38 0.30 0.50 3 522 3 0 3 0 7
4ENB_A 0.76 0.58 1.00 11 1264 0 0 0 0 8
4ENC_A 0.31 0.26 0.38 5 1313 8 1 7 0 14
4FNJ_A - 0.79 0.63 1.00 10 585 0 0 0 0 6
4FRG_B 0.30 0.22 0.41 7 3469 10 1 9 0 25
4FRN_A 0.45 0.36 0.57 13 5128 10 2 8 0 23
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0

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Performance of RNAsubopt - scored lower in this pairwise comparison

1. Total counts & total scores for RNAsubopt

Total Base Pair Counts
Total TP 1756
Total TN 589436
Total FP 1019
Total FP CONTRA 117
Total FP INCONS 770
Total FP COMP 132
Total FN 1522
Total Scores
MCC 0.595
Average MCC ± 95% Confidence Intervals 0.665 ± 0.055
Sensitivity 0.536
Positive Predictive Value 0.664
Nr of predictions 115

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2. Individual counts for RNAsubopt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KD8_A - 0.88 0.78 1.00 7 224 0 0 0 0 2
2KE6_A 0.86 0.84 0.89 16 1110 3 0 2 1 3
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.52 0.43 0.65 17 5125 12 3 6 3 23
2KU0_A - 0.83 0.69 1.00 11 692 0 0 0 0 5
2KUR_A 0.85 0.81 0.89 17 1109 2 0 2 0 4
2KUU_A 0.82 0.76 0.89 16 1110 3 0 2 1 5
2KUV_A 0.83 0.77 0.89 17 1109 2 0 2 0 5
2KUW_A 0.90 0.86 0.95 18 1109 1 0 1 0 3
2KX8_A 0.91 0.83 1.00 15 846 0 0 0 0 3
2KXM_A - 0.89 0.80 1.00 8 343 0 0 0 0 2
2KZL_A - 0.86 0.74 1.00 14 1471 0 0 0 0 5
2L1F_A 0.93 0.88 1.00 21 2059 0 0 0 0 3
2L1F_B 0.94 0.88 1.00 22 2123 0 0 0 0 3
2L2K_A - 0.94 0.89 1.00 17 844 0 0 0 0 2
2L3C_B - 0.87 0.76 1.00 13 548 0 0 0 0 4
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.94 0.88 1.00 30 2455 0 0 0 0 4
2L5Z_A - 0.86 0.75 1.00 9 316 0 0 0 0 3
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LA5_A - 0.39 0.26 0.63 5 622 3 1 2 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
2LDL_A - 0.90 0.82 1.00 9 342 1 0 0 1 2
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.81 0.77 0.86 30 6070 9 0 5 4 9
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LWK_A - 0.83 0.77 0.91 10 485 1 0 1 0 3
2RRC_A - 0.83 0.70 1.00 7 224 0 0 0 0 3
2WRQ_Y 0.57 0.59 0.56 10 2832 12 5 3 4 7
2WW9_D - 0.15 0.12 0.21 3 1939 11 4 7 0 23
2WW9_E - -0.01 0.00 0.00 0 556 5 0 5 0 14
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WWQ_V 0.76 0.68 0.86 19 2904 5 0 3 2 9
2XKV_B 0.51 0.50 0.53 10 4541 23 0 9 14 10
2XQD_Y 0.75 0.67 0.86 18 2829 3 0 3 0 9
2XXA_G 0.47 0.43 0.53 18 5117 16 1 15 0 24
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.66 0.63 0.71 15 2257 8 1 5 2 9
2YIE_X - 0.82 0.67 1.00 8 1370 3 0 0 3 4
2YIE_Z - -0.01 0.00 0.00 0 1525 15 3 12 0 12
3A2K_C 0.42 0.39 0.46 11 2902 13 2 11 0 17
3ADB_C - 0.92 0.84 1.00 32 4154 0 0 0 0 6
3AKZ_H 0.39 0.36 0.43 10 2678 13 2 11 0 18
3AM1_B - 0.91 0.83 1.00 29 3211 0 0 0 0 6
3AMU_B 0.70 0.59 0.84 16 2984 5 0 3 2 11
3GX2_A 0.44 0.38 0.54 15 4343 14 1 12 1 25
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3IVN_B 0.76 0.58 1.00 18 2328 0 0 0 0 13
3IWN_A 0.63 0.58 0.70 19 4251 9 0 8 1 14
3IYQ_A 0.33 0.36 0.30 34 60614 82 17 61 4 60
3IZ4_A 0.51 0.47 0.56 62 70766 49 8 40 1 70
3IZF_C 0.70 0.61 0.80 33 6862 8 1 7 0 21
3J0L_g - -0.01 0.00 0.00 0 460 5 1 4 0 4
3J0L_7 - -0.01 0.00 0.00 0 1213 12 0 12 0 17
3J0L_h - 0.75 0.60 0.93 26 6077 4 0 2 2 17
3J0L_1 - 0.76 0.63 0.92 12 1212 2 0 1 1 7
3J0L_a - 0.35 0.31 0.42 5 1116 7 1 6 0 11
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_2 - 0.25 0.24 0.28 8 6187 25 0 21 4 25
3J16_L 0.41 0.37 0.48 11 2752 12 1 11 0 19
3J20_0 0.43 0.40 0.48 12 2825 14 0 13 1 18
3J20_1 0.96 0.91 1.00 21 2905 2 0 0 2 2
3J2C_O - 0.56 0.49 0.65 31 10248 17 1 16 0 32
3J2C_M - 0.44 0.37 0.52 76 106346 72 8 61 3 131
3J2L_3 0.61 0.53 0.72 28 7836 13 0 11 2 25
3JYV_7 -0.01 0.00 0.00 0 2829 21 0 21 0 32
3JYX_4 0.19 0.21 0.17 7 12204 38 11 24 3 26
3JYX_3 0.63 0.63 0.63 17 6301 21 1 9 11 10
3KTW_C - 0.75 0.65 0.88 28 4528 5 2 2 1 15
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.77 0.69 0.86 42 9131 8 0 7 1 19
3NKB_B - 0.57 0.50 0.65 13 1996 7 0 7 0 13
3NMU_E - 0.54 0.50 0.60 3 556 5 0 2 3 3
3NPB_A 0.75 0.65 0.86 30 6986 7 1 4 2 16
3O58_2 0.72 0.74 0.70 28 7220 13 4 8 1 10
3O58_3 0.34 0.34 0.34 12 12368 34 2 21 11 23
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.75 0.63 0.90 45 12830 7 1 4 2 27
3R4F_A - 0.96 0.92 1.00 23 2122 0 0 0 0 2
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.61 0.50 0.75 21 3888 7 1 6 0 21
3SIU_F - 0.85 0.73 1.00 8 370 0 0 0 0 3
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.38 0.32 0.46 12 3134 14 0 14 0 25
3UZL_B 0.48 0.38 0.61 14 3547 9 0 9 0 23
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.87 0.78 0.97 31 4721 2 0 1 1 9
3ZEX_F - 0.00 0.00 0.00 0 2617 11 2 9 0 12
3ZEX_C 0.24 0.21 0.28 11 14157 42 1 27 14 41
3ZEX_G - 0.46 0.42 0.52 31 16411 32 3 26 3 43
3ZEX_D 0.80 0.69 0.92 34 6984 3 0 3 0 15
3ZEX_E - 0.00 0.00 0.00 0 21893 54 4 48 2 77
3ZEX_H - 0.18 0.18 0.18 7 9006 32 6 26 0 31
4A1C_2 0.14 0.15 0.13 5 11742 43 5 29 9 28
4A1C_3 0.70 0.59 0.82 32 7101 7 1 6 0 22
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.52 0.43 0.64 18 4343 11 2 8 1 24
4ATO_G - 0.30 0.30 0.33 3 519 6 2 4 0 7
4ENB_A 0.70 0.58 0.85 11 1262 2 1 1 0 8
4ENC_A 0.32 0.26 0.42 5 1314 7 0 7 0 14
4FNJ_A - 0.79 0.63 1.00 10 585 0 0 0 0 6
4FRG_B 0.32 0.28 0.38 9 3462 15 0 15 0 23
4FRN_A 0.51 0.44 0.59 16 5124 11 3 8 0 20
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.