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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of McQFold - scored higher in this pairwise comparison

  4. Performance of CMfinder(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for McQFold & CMfinder(20) [.zip] - may take several seconds...


Overview

Metric McQFold CMfinder(20)
MCC 0.664 > 0.546
Average MCC ± 95% Confidence Intervals 0.678 ± 0.165 > 0.560 ± 0.222
Sensitivity 0.530 > 0.366
Positive Predictive Value 0.837 > 0.822
Total TP 87 > 60
Total TN 21128 < 21159
Total FP 20 > 15
Total FP CONTRA 2 > 1
Total FP INCONS 15 > 12
Total FP COMP 3 > 2
Total FN 77 < 104
P-value 0.0

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Performance plots


  1. Comparison of performance of McQFold and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for McQFold and CMfinder(20)).

  2. Comparison of performance of McQFold and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for McQFold and CMfinder(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for McQFold and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for McQFold and CMfinder(20)).

  4. Comparison of average Matthews Correlation Coefficients (MCCs) for McQFold and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for McQFold and CMfinder(20)).

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Performance of McQFold - scored higher in this pairwise comparison

1. Total counts & total scores for McQFold

Total Base Pair Counts
Total TP 87
Total TN 21128
Total FP 20
Total FP CONTRA 2
Total FP INCONS 15
Total FP COMP 3
Total FN 77
Total Scores
MCC 0.664
Average MCC ± 95% Confidence Intervals 0.678 ± 0.165
Sensitivity 0.530
Positive Predictive Value 0.837
Nr of predictions 4

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2. Individual counts for McQFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.66 0.57 0.77 17 2828 6 1 4 1 13
3J2L_3 0.56 0.43 0.72 23 7843 11 0 9 2 30
3ZEX_D 0.69 0.53 0.90 26 6992 3 1 2 0 23
4FRG_B 0.81 0.66 1.00 21 3465 0 0 0 0 11

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Performance of CMfinder(20) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 60
Total TN 21159
Total FP 15
Total FP CONTRA 1
Total FP INCONS 12
Total FP COMP 2
Total FN 104
Total Scores
MCC 0.546
Average MCC ± 95% Confidence Intervals 0.560 ± 0.222
Sensitivity 0.366
Positive Predictive Value 0.822
Nr of predictions 4

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.75 0.57 1.00 17 2833 1 0 0 1 13
3J2L_3 0.45 0.32 0.63 17 7848 11 1 9 1 36
3ZEX_D 0.58 0.39 0.86 19 6999 3 0 3 0 30
4FRG_B 0.47 0.22 1.00 7 3479 0 0 0 0 25

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.