CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of McQFold - scored higher in this pairwise comparison

  4. Performance of Vsfold4 - scored lower in this pairwise comparison

  5. Compile and download dataset for McQFold & Vsfold4 [.zip] - may take several seconds...


Overview

Metric McQFold Vsfold4
MCC 0.599 > 0.545
Average MCC ± 95% Confidence Intervals 0.671 ± 0.052 > 0.619 ± 0.054
Sensitivity 0.519 > 0.463
Positive Predictive Value 0.696 > 0.648
Total TP 1685 > 1504
Total TN 477647 < 477745
Total FP 836 < 905
Total FP CONTRA 102 > 82
Total FP INCONS 633 < 736
Total FP COMP 101 > 87
Total FN 1564 < 1745
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of McQFold and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for McQFold and Vsfold4).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for McQFold and Vsfold4).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for McQFold and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for McQFold and Vsfold4).

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Performance of McQFold - scored higher in this pairwise comparison

1. Total counts & total scores for McQFold

Total Base Pair Counts
Total TP 1685
Total TN 477647
Total FP 836
Total FP CONTRA 102
Total FP INCONS 633
Total FP COMP 101
Total FN 1564
Total Scores
MCC 0.599
Average MCC ± 95% Confidence Intervals 0.671 ± 0.052
Sensitivity 0.519
Positive Predictive Value 0.696
Nr of predictions 128

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2. Individual counts for McQFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.60 0.36 1.00 4 402 0 0 0 0 7
2K63_A - 0.95 0.90 1.00 9 397 0 0 0 0 1
2K66_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2KD8_A - 1.00 1.00 1.00 9 222 1 0 0 1 0
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.89 0.79 1.00 15 1113 1 0 0 1 4
2KEZ_A - 0.89 0.80 1.00 8 268 0 0 0 0 2
2KFC_A - 0.49 0.25 1.00 5 625 0 0 0 0 15
2KGP_A - 0.81 0.67 1.00 6 294 1 0 0 1 3
2KMJ_A - 1.00 1.00 1.00 11 367 1 0 0 1 0
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.59 0.53 0.68 21 5120 13 3 7 3 19
2KU0_A - 0.75 0.56 1.00 9 694 0 0 0 0 7
2KUR_A 0.87 0.76 1.00 16 1112 0 0 0 0 5
2KUU_A 0.84 0.71 1.00 15 1113 1 0 0 1 6
2KUV_A 0.85 0.73 1.00 16 1112 0 0 0 0 6
2KUW_A 0.87 0.76 1.00 16 1112 0 0 0 0 5
2KX8_A 0.88 0.83 0.94 15 845 1 0 1 0 3
2KXM_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
2KZL_A - 0.86 0.74 1.00 14 1471 1 0 0 1 5
2L1F_A 0.98 0.96 1.00 23 2057 0 0 0 0 1
2L1F_B 0.98 0.96 1.00 24 2121 0 0 0 0 1
2L2K_A - 0.97 0.95 1.00 18 843 0 0 0 0 1
2L3C_B - 0.94 0.88 1.00 15 546 0 0 0 0 2
2L3E_A - 1.00 1.00 1.00 13 582 1 0 0 1 0
2L3J_B 0.89 0.79 1.00 27 2458 0 0 0 0 7
2L5Z_A - 0.86 0.75 1.00 9 316 0 0 0 0 3
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LA5_A - 0.46 0.26 0.83 5 624 1 0 1 0 14
2LBS_A - 1.00 1.00 1.00 14 482 1 0 0 1 0
2LC8_A 0.61 0.55 0.69 11 1524 5 0 5 0 9
2LDL_A - 0.73 0.55 1.00 6 345 0 0 0 0 5
2LDT_A - 0.68 0.47 1.00 7 458 0 0 0 0 8
2LHP_A - 1.00 1.00 1.00 16 650 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.51 0.46 0.58 18 6074 13 2 11 0 21
2LQZ_A - 0.91 0.91 0.91 10 340 1 1 0 0 1
2LWK_A - 0.83 0.77 0.91 10 485 2 0 1 1 3
2RP0_A - 0.64 0.42 1.00 5 346 0 0 0 0 7
2RPT_A - 1.00 1.00 1.00 7 183 0 0 0 0 0
2RRC_A - 0.70 0.50 1.00 5 226 0 0 0 0 5
2WRQ_Y 0.57 0.59 0.56 10 2832 13 5 3 5 7
2WW9_E - -0.01 0.00 0.00 0 556 5 0 5 0 14
2WW9_D - 0.32 0.23 0.46 6 1940 7 2 5 0 20
2WW9_F - 0.71 0.60 0.86 6 293 1 0 1 0 4
2WWQ_V 0.00 0.00 0.00 0 2926 0 0 0 0 28
2XKV_B 0.31 0.30 0.33 6 4542 25 1 11 13 14
2XQD_Y 0.88 0.78 1.00 21 2829 0 0 0 0 6
2XXA_G 0.27 0.24 0.32 10 5120 21 0 21 0 32
2Y8W_B - 1.00 1.00 1.00 6 184 2 0 0 2 0
2Y9C_V - 0.59 0.54 0.65 13 2258 8 1 6 1 11
2YIE_X - 0.36 0.33 0.40 4 1368 6 2 4 0 8
2YIE_Z - 0.43 0.42 0.45 5 1529 6 3 3 0 7
2ZY6_A - 0.58 0.58 0.58 7 691 5 1 4 0 5
2ZZM_B 0.21 0.19 0.24 6 3461 19 2 17 0 26
2ZZN_D 0.84 0.78 0.91 21 2462 2 0 2 0 6
3A2K_C 0.86 0.75 1.00 21 2905 0 0 0 0 7
3A3A_A 0.87 0.76 1.00 28 3627 0 0 0 0 9
3ADB_C - 0.92 0.84 1.00 32 4154 1 0 0 1 6
3AKZ_H 0.68 0.61 0.77 17 2679 6 1 4 1 11
3AM1_B - 0.91 0.83 1.00 29 3211 1 0 0 1 6
3AMU_B 0.75 0.59 0.94 16 2986 3 0 1 2 11
3DW4_A - -0.02 0.00 0.00 0 348 3 0 3 0 10
3G4S_9 0.27 0.21 0.36 12 7348 21 1 20 0 45
3GCA_A - 0.54 0.29 1.00 5 523 0 0 0 0 12
3GX2_A 0.47 0.40 0.57 16 4343 13 1 11 1 24
3HAY_E - 0.91 0.83 1.00 15 2263 3 0 0 3 3
3HJW_D - 0.88 0.83 0.94 15 1637 3 0 1 2 3
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3ID5_D - 0.49 0.33 0.75 3 492 6 0 1 5 6
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IWN_A 0.20 0.18 0.24 6 4253 19 2 17 0 27
3IYQ_A 0.28 0.31 0.26 29 60614 87 19 64 4 65
3IZ4_A 0.42 0.36 0.49 47 70780 53 6 43 4 85
3IZF_C 0.68 0.56 0.83 30 6867 6 0 6 0 24
3J0L_1 - 0.65 0.47 0.90 9 1215 3 0 1 2 10
3J0L_2 - 0.26 0.24 0.30 8 6189 21 0 19 2 25
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_7 - -0.01 0.00 0.00 0 1215 10 0 10 0 17
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_a - 0.26 0.19 0.38 3 1120 5 1 4 0 13
3J0L_h - 0.65 0.49 0.88 21 6081 3 0 3 0 22
3J16_L 0.75 0.57 1.00 17 2758 0 0 0 0 13
3J20_1 0.96 0.91 1.00 21 2905 0 0 0 0 2
3J20_0 0.66 0.57 0.77 17 2828 6 1 4 1 13
3J2C_O - 0.53 0.43 0.66 27 10255 15 1 13 1 36
3J2L_3 0.56 0.43 0.72 23 7843 11 0 9 2 30
3JYV_7 -0.01 0.00 0.00 0 2830 20 0 20 0 32
3JYX_3 0.21 0.22 0.20 6 6298 24 9 15 0 21
3JYX_4 0.20 0.21 0.19 7 12210 33 8 21 4 26
3KTW_C - 0.36 0.30 0.45 13 4531 17 1 15 1 30
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.81 0.70 0.93 43 9134 4 1 2 1 18
3NKB_B - 0.36 0.31 0.44 8 1998 10 1 9 0 18
3NMU_E - 0.41 0.17 1.00 1 560 3 0 0 3 5
3NPB_A 0.81 0.67 0.97 31 6989 4 1 0 3 15
3O58_3 0.26 0.26 0.26 9 12368 26 10 16 0 26
3O58_2 0.83 0.71 0.96 27 7232 2 0 1 1 11
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.69 0.56 0.87 40 12834 9 0 6 3 32
3R4F_A - 0.96 0.92 1.00 23 2122 1 0 0 1 2
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.71 0.60 0.86 25 3887 4 0 4 0 17
3SIU_F - 0.73 0.55 1.00 6 372 0 0 0 0 5
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 2 0 0 2 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.73 0.57 0.95 21 3138 1 0 1 0 16
3UZL_B 0.45 0.41 0.52 15 3541 14 0 14 0 22
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.44 0.38 0.54 15 4725 14 0 13 1 25
3ZEX_D 0.69 0.53 0.90 26 6992 3 1 2 0 23
3ZEX_G - 0.31 0.27 0.36 20 16416 38 1 34 3 54
3ZEX_E - 0.00 0.00 0.00 0 21894 53 4 47 2 77
4A1C_3 0.25 0.22 0.29 12 7099 29 1 28 0 42
4A1C_2 0.15 0.15 0.15 5 11748 33 5 23 5 28
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.42 0.33 0.54 14 4345 13 1 11 1 28
4ATO_G - -0.01 0.00 0.00 0 523 5 0 5 0 10
4ENB_A 0.89 0.79 1.00 15 1260 0 0 0 0 4
4ENC_A 0.86 0.79 0.94 15 1310 1 1 0 0 4
4FRG_B 0.81 0.66 1.00 21 3465 0 0 0 0 11
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0

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Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 1504
Total TN 477745
Total FP 905
Total FP CONTRA 82
Total FP INCONS 736
Total FP COMP 87
Total FN 1745
Total Scores
MCC 0.545
Average MCC ± 95% Confidence Intervals 0.619 ± 0.054
Sensitivity 0.463
Positive Predictive Value 0.648
Nr of predictions 128

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.37 0.36 0.40 4 396 6 0 6 0 7
2K63_A - 0.95 0.90 1.00 9 397 0 0 0 0 1
2K66_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KEZ_A - 0.70 0.50 1.00 5 271 0 0 0 0 5
2KFC_A - 0.49 0.25 1.00 5 625 0 0 0 0 15
2KGP_A - -0.02 0.00 0.00 0 296 4 0 4 0 9
2KMJ_A - 1.00 1.00 1.00 11 367 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.65 0.53 0.81 21 5125 7 0 5 2 19
2KU0_A - -0.02 0.00 0.00 0 694 9 0 9 0 16
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2KXM_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
2KZL_A - 0.86 0.74 1.00 14 1471 0 0 0 0 5
2L1F_A 0.66 0.54 0.81 13 2064 3 0 3 0 11
2L1F_B 0.68 0.56 0.82 14 2128 3 0 3 0 11
2L2K_A - 0.89 0.79 1.00 15 846 0 0 0 0 4
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.87 0.76 1.00 26 2459 0 0 0 0 8
2L5Z_A - 0.60 0.50 0.75 6 317 2 0 2 0 6
2L94_A 0.92 0.85 1.00 17 973 0 0 0 0 3
2LA5_A - 0.46 0.26 0.83 5 624 1 0 1 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A -0.01 0.00 0.00 0 1527 13 0 13 0 20
2LDL_A - 0.85 0.73 1.00 8 343 1 0 0 1 3
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.31 0.28 0.34 11 6073 21 3 18 0 28
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LWK_A - 0.83 0.77 0.91 10 485 1 0 1 0 3
2RP0_A - 0.64 0.42 1.00 5 346 0 0 0 0 7
2RPT_A - -0.03 0.00 0.00 0 186 4 0 4 0 7
2RRC_A - 0.70 0.50 1.00 5 226 0 0 0 0 5
2WRQ_Y 0.53 0.53 0.53 9 2833 12 5 3 4 8
2WW9_E - -0.01 0.00 0.00 0 556 5 0 5 0 14
2WW9_D - 0.19 0.12 0.33 3 1944 6 0 6 0 23
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WWQ_V 0.64 0.50 0.82 14 2909 4 0 3 1 14
2XKV_B -0.01 0.00 0.00 0 4533 27 8 19 0 20
2XQD_Y 0.86 0.74 1.00 20 2830 0 0 0 0 7
2XXA_G -0.01 0.00 0.00 0 5122 29 1 28 0 42
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.63 0.50 0.80 12 2263 4 0 3 1 12
2YIE_X - 0.36 0.33 0.40 4 1368 6 2 4 0 8
2YIE_Z - -0.01 0.00 0.00 0 1529 11 3 8 0 12
2ZY6_A - 0.58 0.58 0.58 7 691 5 1 4 0 5
2ZZM_B 0.21 0.19 0.24 6 3461 19 0 19 0 26
2ZZN_D 0.86 0.78 0.95 21 2463 1 0 1 0 6
3A2K_C 0.84 0.71 1.00 20 2906 0 0 0 0 8
3A3A_A 0.85 0.73 1.00 27 3628 0 0 0 0 10
3ADB_C - 0.89 0.79 1.00 30 4156 0 0 0 0 8
3AKZ_H 0.67 0.57 0.80 16 2681 5 1 3 1 12
3AM1_B - 0.84 0.71 1.00 25 3215 0 0 0 0 10
3AMU_B 0.64 0.56 0.75 15 2983 7 0 5 2 12
3DW4_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
3G4S_9 0.30 0.23 0.39 13 7348 20 1 19 0 44
3GCA_A - 0.54 0.29 1.00 5 523 0 0 0 0 12
3GX2_A 0.50 0.40 0.64 16 4346 10 0 9 1 24
3HAY_E - 0.91 0.83 1.00 15 2263 3 0 0 3 3
3HJW_D - 0.51 0.50 0.53 9 1636 8 0 8 0 9
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3ID5_D - 0.44 0.33 0.60 3 491 4 0 2 2 6
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IWN_A 0.27 0.21 0.35 7 4258 13 1 12 0 26
3IYQ_A 0.29 0.29 0.29 27 60634 71 13 52 6 67
3IZ4_A 0.36 0.31 0.43 41 70780 59 7 48 4 91
3IZF_C 0.69 0.56 0.86 30 6868 5 0 5 0 24
3J0L_1 - 0.28 0.21 0.40 4 1215 6 1 5 0 15
3J0L_2 - 0.38 0.36 0.41 12 6187 18 3 14 1 21
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_7 - 0.51 0.41 0.64 7 1214 4 0 4 0 10
3J0L_8 - 0.70 0.50 1.00 4 186 0 0 0 0 4
3J0L_a - 0.39 0.31 0.50 5 1118 5 2 3 0 11
3J0L_h - 0.38 0.28 0.52 12 6082 11 0 11 0 31
3J16_L 0.82 0.67 1.00 20 2755 0 0 0 0 10
3J20_1 0.71 0.70 0.73 16 2904 6 0 6 0 7
3J20_0 0.84 0.70 1.00 21 2829 1 0 0 1 9
3J2C_O - 0.30 0.24 0.39 15 10258 24 0 23 1 48
3J2L_3 0.57 0.45 0.73 24 7842 12 1 8 3 29
3JYV_7 -0.01 0.00 0.00 0 2831 19 0 19 0 32
3JYX_3 0.60 0.56 0.65 15 6305 11 4 4 3 12
3JYX_4 0.10 0.09 0.12 3 12220 33 2 21 10 30
3KTW_C - 0.36 0.28 0.48 12 4535 13 3 10 0 31
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.28 0.23 0.35 14 9140 26 0 26 0 47
3NKB_B - 0.59 0.54 0.67 14 1995 7 0 7 0 12
3NMU_E - 0.41 0.17 1.00 1 560 3 0 0 3 5
3NPB_A 0.61 0.50 0.74 23 6990 9 0 8 1 23
3O58_3 0.09 0.09 0.10 3 12373 35 5 22 8 32
3O58_2 0.47 0.42 0.53 16 7230 16 3 11 2 22
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.57 0.44 0.74 32 12837 13 0 11 2 40
3R4F_A - 0.94 0.88 1.00 22 2123 0 0 0 0 3
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.19 0.17 0.24 7 3887 22 1 21 0 35
3SIU_F - 0.73 0.55 1.00 6 372 0 0 0 0 5
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.38 0.32 0.46 12 3134 14 0 14 0 25
3UZL_B 0.53 0.41 0.71 15 3549 6 1 5 0 22
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.67 0.58 0.79 23 4724 7 0 6 1 17
3ZEX_D 0.55 0.45 0.69 22 6989 10 0 10 0 27
3ZEX_G - 0.30 0.23 0.39 17 16427 27 2 25 0 57
3ZEX_E - 0.08 0.06 0.11 5 21900 40 1 39 0 72
4A1C_3 0.26 0.22 0.32 12 7103 25 2 23 0 42
4A1C_2 0.28 0.24 0.33 8 11757 28 0 16 12 25
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.42 0.33 0.54 14 4345 13 1 11 1 28
4ATO_G - 0.32 0.30 0.38 3 520 5 1 4 0 7
4ENB_A 0.76 0.58 1.00 11 1264 0 0 0 0 8
4ENC_A 0.69 0.47 1.00 9 1317 0 0 0 0 10
4FRG_B 0.56 0.47 0.68 15 3464 7 1 6 0 17
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.