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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of McQFold - scored higher in this pairwise comparison

  4. Performance of Vsfold5 - scored lower in this pairwise comparison

  5. Compile and download dataset for McQFold & Vsfold5 [.zip] - may take several seconds...


Overview

Metric McQFold Vsfold5
MCC 0.604 > 0.507
Average MCC ± 95% Confidence Intervals 0.669 ± 0.052 > 0.598 ± 0.059
Sensitivity 0.523 > 0.439
Positive Predictive Value 0.705 > 0.594
Total TP 1669 > 1401
Total TN 465702 < 465711
Total FP 798 < 1045
Total FP CONTRA 101 < 110
Total FP INCONS 599 < 849
Total FP COMP 98 > 86
Total FN 1525 < 1793
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of McQFold and Vsfold5. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for McQFold and Vsfold5).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for McQFold and Vsfold5).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for McQFold and Vsfold5. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for McQFold and Vsfold5).

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Performance of McQFold - scored higher in this pairwise comparison

1. Total counts & total scores for McQFold

Total Base Pair Counts
Total TP 1669
Total TN 465702
Total FP 798
Total FP CONTRA 101
Total FP INCONS 599
Total FP COMP 98
Total FN 1525
Total Scores
MCC 0.604
Average MCC ± 95% Confidence Intervals 0.669 ± 0.052
Sensitivity 0.523
Positive Predictive Value 0.705
Nr of predictions 126

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2. Individual counts for McQFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.60 0.36 1.00 4 402 0 0 0 0 7
2K63_A - 0.95 0.90 1.00 9 397 0 0 0 0 1
2K66_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2KD8_A - 1.00 1.00 1.00 9 222 1 0 0 1 0
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.89 0.79 1.00 15 1113 1 0 0 1 4
2KEZ_A - 0.89 0.80 1.00 8 268 0 0 0 0 2
2KFC_A - 0.49 0.25 1.00 5 625 0 0 0 0 15
2KGP_A - 0.81 0.67 1.00 6 294 1 0 0 1 3
2KMJ_A - 1.00 1.00 1.00 11 367 1 0 0 1 0
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.59 0.53 0.68 21 5120 13 3 7 3 19
2KU0_A - 0.75 0.56 1.00 9 694 0 0 0 0 7
2KUR_A 0.87 0.76 1.00 16 1112 0 0 0 0 5
2KUU_A 0.84 0.71 1.00 15 1113 1 0 0 1 6
2KUV_A 0.85 0.73 1.00 16 1112 0 0 0 0 6
2KUW_A 0.87 0.76 1.00 16 1112 0 0 0 0 5
2KX8_A 0.88 0.83 0.94 15 845 1 0 1 0 3
2KXM_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
2KZL_A - 0.86 0.74 1.00 14 1471 1 0 0 1 5
2L1F_A 0.98 0.96 1.00 23 2057 0 0 0 0 1
2L1F_B 0.98 0.96 1.00 24 2121 0 0 0 0 1
2L2K_A - 0.97 0.95 1.00 18 843 0 0 0 0 1
2L3C_B - 0.94 0.88 1.00 15 546 0 0 0 0 2
2L3E_A - 1.00 1.00 1.00 13 582 1 0 0 1 0
2L3J_B 0.89 0.79 1.00 27 2458 0 0 0 0 7
2L5Z_A - 0.86 0.75 1.00 9 316 0 0 0 0 3
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LA5_A - 0.46 0.26 0.83 5 624 1 0 1 0 14
2LBS_A - 1.00 1.00 1.00 14 482 1 0 0 1 0
2LC8_A 0.61 0.55 0.69 11 1524 5 0 5 0 9
2LDL_A - 0.73 0.55 1.00 6 345 0 0 0 0 5
2LDT_A - 0.68 0.47 1.00 7 458 0 0 0 0 8
2LHP_A - 1.00 1.00 1.00 16 650 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.51 0.46 0.58 18 6074 13 2 11 0 21
2LWK_A - 0.83 0.77 0.91 10 485 2 0 1 1 3
2RP0_A - 0.64 0.42 1.00 5 346 0 0 0 0 7
2RPT_A - 1.00 1.00 1.00 7 183 0 0 0 0 0
2RRC_A - 0.70 0.50 1.00 5 226 0 0 0 0 5
2WRQ_Y 0.57 0.59 0.56 10 2832 13 5 3 5 7
2WW9_E - -0.01 0.00 0.00 0 556 5 0 5 0 14
2WW9_D - 0.32 0.23 0.46 6 1940 7 2 5 0 20
2WW9_F - 0.71 0.60 0.86 6 293 1 0 1 0 4
2WWQ_V 0.00 0.00 0.00 0 2926 0 0 0 0 28
2XKV_B 0.31 0.30 0.33 6 4542 25 1 11 13 14
2XQD_Y 0.88 0.78 1.00 21 2829 0 0 0 0 6
2XXA_G 0.27 0.24 0.32 10 5120 21 0 21 0 32
2Y8W_B - 1.00 1.00 1.00 6 184 2 0 0 2 0
2Y9C_V - 0.59 0.54 0.65 13 2258 8 1 6 1 11
2YIE_Z - 0.43 0.42 0.45 5 1529 6 3 3 0 7
2YIE_X - 0.36 0.33 0.40 4 1368 6 2 4 0 8
2ZY6_A - 0.58 0.58 0.58 7 691 5 1 4 0 5
2ZZM_B 0.21 0.19 0.24 6 3461 19 2 17 0 26
2ZZN_D 0.84 0.78 0.91 21 2462 2 0 2 0 6
3A2K_C 0.86 0.75 1.00 21 2905 0 0 0 0 7
3A3A_A 0.87 0.76 1.00 28 3627 0 0 0 0 9
3ADB_C - 0.92 0.84 1.00 32 4154 1 0 0 1 6
3AKZ_H 0.68 0.61 0.77 17 2679 6 1 4 1 11
3AM1_B - 0.91 0.83 1.00 29 3211 1 0 0 1 6
3AMU_B 0.75 0.59 0.94 16 2986 3 0 1 2 11
3DW4_A - -0.02 0.00 0.00 0 348 3 0 3 0 10
3G4S_9 0.27 0.21 0.36 12 7348 21 1 20 0 45
3GCA_A - 0.54 0.29 1.00 5 523 0 0 0 0 12
3GX2_A 0.47 0.40 0.57 16 4343 13 1 11 1 24
3HAY_E - 0.91 0.83 1.00 15 2263 3 0 0 3 3
3HJW_D - 0.88 0.83 0.94 15 1637 3 0 1 2 3
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3ID5_D - 0.49 0.33 0.75 3 492 6 0 1 5 6
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IWN_A 0.20 0.18 0.24 6 4253 19 2 17 0 27
3IYQ_A 0.28 0.31 0.26 29 60614 87 19 64 4 65
3IZ4_A 0.42 0.36 0.49 47 70780 53 6 43 4 85
3IZF_C 0.68 0.56 0.83 30 6867 6 0 6 0 24
3J0L_1 - 0.65 0.47 0.90 9 1215 3 0 1 2 10
3J0L_2 - 0.26 0.24 0.30 8 6189 21 0 19 2 25
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_7 - -0.01 0.00 0.00 0 1215 10 0 10 0 17
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_a - 0.26 0.19 0.38 3 1120 5 1 4 0 13
3J0L_h - 0.65 0.49 0.88 21 6081 3 0 3 0 22
3J16_L 0.75 0.57 1.00 17 2758 0 0 0 0 13
3J20_1 0.96 0.91 1.00 21 2905 0 0 0 0 2
3J20_0 0.66 0.57 0.77 17 2828 6 1 4 1 13
3J2C_O - 0.53 0.43 0.66 27 10255 15 1 13 1 36
3J2L_3 0.56 0.43 0.72 23 7843 11 0 9 2 30
3JYV_7 -0.01 0.00 0.00 0 2830 20 0 20 0 32
3JYX_4 0.20 0.21 0.19 7 12210 33 8 21 4 26
3JYX_3 0.21 0.22 0.20 6 6298 24 9 15 0 21
3KTW_C - 0.36 0.30 0.45 13 4531 17 1 15 1 30
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.81 0.70 0.93 43 9134 4 1 2 1 18
3NKB_B - 0.36 0.31 0.44 8 1998 10 1 9 0 18
3NMU_E - 0.41 0.17 1.00 1 560 3 0 0 3 5
3NPB_A 0.81 0.67 0.97 31 6989 4 1 0 3 15
3O58_3 0.26 0.26 0.26 9 12368 26 10 16 0 26
3O58_2 0.83 0.71 0.96 27 7232 2 0 1 1 11
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.69 0.56 0.87 40 12834 9 0 6 3 32
3R4F_A - 0.96 0.92 1.00 23 2122 1 0 0 1 2
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.71 0.60 0.86 25 3887 4 0 4 0 17
3SIU_F - 0.73 0.55 1.00 6 372 0 0 0 0 5
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 2 0 0 2 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.73 0.57 0.95 21 3138 1 0 1 0 16
3UZL_B 0.45 0.41 0.52 15 3541 14 0 14 0 22
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.44 0.38 0.54 15 4725 14 0 13 1 25
3ZEX_D 0.69 0.53 0.90 26 6992 3 1 2 0 23
3ZEX_E - 0.00 0.00 0.00 0 21894 53 4 47 2 77
4A1C_3 0.25 0.22 0.29 12 7099 29 1 28 0 42
4A1C_2 0.15 0.15 0.15 5 11748 33 5 23 5 28
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.42 0.33 0.54 14 4345 13 1 11 1 28
4ATO_G - -0.01 0.00 0.00 0 523 5 0 5 0 10
4ENB_A 0.89 0.79 1.00 15 1260 0 0 0 0 4
4ENC_A 0.86 0.79 0.94 15 1310 1 1 0 0 4
4FRG_B 0.81 0.66 1.00 21 3465 0 0 0 0 11
4FRN_A 0.73 0.56 0.95 20 5130 1 1 0 0 16

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Performance of Vsfold5 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP 1401
Total TN 465711
Total FP 1045
Total FP CONTRA 110
Total FP INCONS 849
Total FP COMP 86
Total FN 1793
Total Scores
MCC 0.507
Average MCC ± 95% Confidence Intervals 0.598 ± 0.059
Sensitivity 0.439
Positive Predictive Value 0.594
Nr of predictions 126

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 395 0 0 0 0 0
2K63_A - 0.95 0.90 1.00 9 397 0 0 0 0 1
2K66_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KDQ_B 0.90 0.82 1.00 9 397 0 0 0 0 2
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KEZ_A - 0.70 0.50 1.00 5 271 0 0 0 0 5
2KFC_A - 0.48 0.35 0.70 7 620 3 0 3 0 13
2KGP_A - 0.81 0.67 1.00 6 294 1 0 0 1 3
2KMJ_A - 0.95 0.91 1.00 10 368 0 0 0 0 1
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.57 0.50 0.65 20 5120 11 5 6 0 20
2KU0_A - -0.02 0.00 0.00 0 692 11 0 11 0 16
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KX8_A 0.91 0.83 1.00 15 846 0 0 0 0 3
2KXM_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
2KZL_A - 0.86 0.74 1.00 14 1471 0 0 0 0 5
2L1F_A 0.69 0.58 0.82 14 2063 3 0 3 0 10
2L1F_B 0.70 0.60 0.83 15 2127 3 0 3 0 10
2L2K_A - 0.89 0.79 1.00 15 846 0 0 0 0 4
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.87 0.76 1.00 26 2459 0 0 0 0 8
2L5Z_A - 0.60 0.50 0.75 6 317 2 0 2 0 6
2L94_A 0.95 0.90 1.00 18 972 0 0 0 0 2
2LA5_A - -0.02 0.00 0.00 0 623 7 0 7 0 19
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A -0.01 0.00 0.00 0 1527 13 0 13 0 20
2LDL_A - 0.85 0.73 1.00 8 343 1 0 0 1 3
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.89 0.80 1.00 8 268 0 0 0 0 2
2LKR_A - 0.27 0.23 0.32 9 6077 19 2 17 0 30
2LWK_A - 0.83 0.77 0.91 10 485 1 0 1 0 3
2RP0_A - 0.64 0.42 1.00 5 346 0 0 0 0 7
2RPT_A - 0.70 0.71 0.71 5 183 2 0 2 0 2
2RRC_A - 0.70 0.50 1.00 5 226 0 0 0 0 5
2WRQ_Y 0.53 0.53 0.53 9 2833 12 5 3 4 8
2WW9_E - -0.01 0.00 0.00 0 556 5 0 5 0 14
2WW9_D - 0.15 0.12 0.21 3 1939 11 1 10 0 23
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WWQ_V 0.64 0.50 0.82 14 2909 4 0 3 1 14
2XKV_B -0.01 0.00 0.00 0 4528 32 12 20 0 20
2XQD_Y 0.86 0.74 1.00 20 2830 0 0 0 0 7
2XXA_G -0.01 0.00 0.00 0 5120 31 2 29 0 42
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.61 0.54 0.68 13 2259 7 1 5 1 11
2YIE_Z - -0.01 0.00 0.00 0 1529 11 3 8 0 12
2YIE_X - 0.30 0.33 0.29 4 1364 10 2 8 0 8
2ZY6_A - 0.58 0.58 0.58 7 691 5 1 4 0 5
2ZZM_B 0.19 0.19 0.21 6 3458 22 1 21 0 26
2ZZN_D 0.86 0.78 0.95 21 2463 1 0 1 0 6
3A2K_C 0.84 0.71 1.00 20 2906 0 0 0 0 8
3A3A_A 0.85 0.73 1.00 27 3628 0 0 0 0 10
3ADB_C - 0.67 0.53 0.87 20 4163 3 0 3 0 18
3AKZ_H 0.84 0.71 1.00 20 2681 0 0 0 0 8
3AM1_B - 0.78 0.71 0.86 25 3211 4 1 3 0 10
3AMU_B 0.67 0.59 0.76 16 2982 7 0 5 2 11
3DW4_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
3G4S_9 0.08 0.07 0.11 4 7344 33 0 33 0 53
3GCA_A - 0.54 0.29 1.00 5 523 0 0 0 0 12
3GX2_A 0.51 0.40 0.67 16 4347 9 0 8 1 24
3HAY_E - 0.91 0.83 1.00 15 2263 3 0 0 3 3
3HJW_D - 0.48 0.50 0.47 9 1634 10 0 10 0 9
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3ID5_D - 0.44 0.33 0.60 3 491 4 0 2 2 6
3IVN_B 0.76 0.58 1.00 18 2328 0 0 0 0 13
3IWN_A 0.25 0.21 0.30 7 4255 16 1 15 0 26
3IYQ_A 0.33 0.31 0.35 29 60642 61 15 40 6 65
3IZ4_A 0.29 0.24 0.36 32 70787 62 8 49 5 100
3IZF_C 0.70 0.56 0.88 30 6869 4 0 4 0 24
3J0L_1 - 0.27 0.21 0.36 4 1214 7 1 6 0 15
3J0L_2 - 0.35 0.33 0.37 11 6186 21 3 16 2 22
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_7 - -0.01 0.00 0.00 0 1212 13 0 13 0 17
3J0L_8 - 0.70 0.50 1.00 4 186 0 0 0 0 4
3J0L_a - 0.39 0.31 0.50 5 1118 5 2 3 0 11
3J0L_h - 0.18 0.14 0.24 6 6080 19 1 18 0 37
3J16_L 0.82 0.67 1.00 20 2755 0 0 0 0 10
3J20_1 0.71 0.70 0.73 16 2904 6 0 6 0 7
3J20_0 0.67 0.57 0.81 17 2829 5 1 3 1 13
3J2C_O - 0.30 0.24 0.39 15 10258 24 0 23 1 48
3J2L_3 0.56 0.45 0.71 24 7841 13 1 9 3 29
3JYV_7 -0.01 0.00 0.00 0 2831 19 0 19 0 32
3JYX_4 0.31 0.30 0.31 10 12214 32 3 19 10 23
3JYX_3 0.17 0.15 0.20 4 6308 18 4 12 2 23
3KTW_C - 0.38 0.30 0.50 13 4534 13 3 10 0 30
3LA5_A -0.01 0.00 0.00 0 2469 16 0 16 0 34
3NDB_M - 0.06 0.05 0.08 3 9144 33 1 32 0 58
3NKB_B - 0.59 0.54 0.67 14 1995 7 0 7 0 12
3NMU_E - 0.20 0.17 0.25 1 557 5 0 3 2 5
3NPB_A 0.57 0.46 0.72 21 6992 9 1 7 1 25
3O58_3 0.39 0.37 0.41 13 12371 28 7 12 9 22
3O58_2 0.45 0.42 0.48 16 7227 19 3 14 2 22
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.57 0.44 0.74 32 12837 13 0 11 2 40
3R4F_A - 0.94 0.88 1.00 22 2123 0 0 0 0 3
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.75 0.65 0.88 22 2186 3 0 3 0 12
3SD1_A 0.11 0.10 0.15 4 3890 22 0 22 0 38
3SIU_F - 0.73 0.55 1.00 6 372 0 0 0 0 5
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.38 0.32 0.46 12 3134 14 0 14 0 25
3UZL_B 0.16 0.14 0.20 5 3545 20 1 19 0 32
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.76 0.70 0.82 28 4719 7 1 5 1 12
3ZEX_D 0.08 0.06 0.11 3 6994 24 0 24 0 46
3ZEX_E - 0.07 0.06 0.08 5 21886 54 5 49 0 72
4A1C_3 0.26 0.22 0.32 12 7103 25 2 23 0 42
4A1C_2 0.24 0.24 0.24 8 11748 37 3 22 12 25
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.18 0.14 0.25 6 4347 19 1 17 1 36
4ATO_G - 0.56 0.60 0.55 6 517 5 1 4 0 4
4ENB_A 0.89 0.79 1.00 15 1260 0 0 0 0 4
4ENC_A 0.86 0.79 0.94 15 1310 1 1 0 0 4
4FRG_B 0.56 0.47 0.68 15 3464 7 1 6 0 17
4FRN_A 0.13 0.11 0.17 4 5128 19 2 17 0 32

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.