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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(20) - scored higher in this pairwise comparison

  4. Performance of CMfinder(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(20) & CMfinder(20) [.zip] - may take several seconds...


Overview

Metric Multilign(20) CMfinder(20)
MCC 0.578 > 0.546
Average MCC ± 95% Confidence Intervals 0.531 ± 0.447 < 0.560 ± 0.222
Sensitivity 0.482 > 0.366
Positive Predictive Value 0.699 < 0.822
Total TP 79 > 60
Total TN 21119 < 21159
Total FP 37 > 15
Total FP CONTRA 2 > 1
Total FP INCONS 32 > 12
Total FP COMP 3 > 2
Total FN 85 < 104
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(20) and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and CMfinder(20)).

  2. Comparison of performance of Multilign(20) and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and CMfinder(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and CMfinder(20)).

  4. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and CMfinder(20)).

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Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 79
Total TN 21119
Total FP 37
Total FP CONTRA 2
Total FP INCONS 32
Total FP COMP 3
Total FN 85
Total Scores
MCC 0.578
Average MCC ± 95% Confidence Intervals 0.531 ± 0.447
Sensitivity 0.482
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.61 0.53 0.70 16 2827 8 1 6 1 14
3J2L_3 0.65 0.53 0.80 28 7840 9 0 7 2 25
3ZEX_D 0.75 0.65 0.86 32 6984 5 1 4 0 17
4FRG_B 0.12 0.09 0.17 3 3468 15 0 15 0 29

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Performance of CMfinder(20) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 60
Total TN 21159
Total FP 15
Total FP CONTRA 1
Total FP INCONS 12
Total FP COMP 2
Total FN 104
Total Scores
MCC 0.546
Average MCC ± 95% Confidence Intervals 0.560 ± 0.222
Sensitivity 0.366
Positive Predictive Value 0.822
Nr of predictions 4

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.75 0.57 1.00 17 2833 1 0 0 1 13
3J2L_3 0.45 0.32 0.63 17 7848 11 1 9 1 36
3ZEX_D 0.58 0.39 0.86 19 6999 3 0 3 0 30
4FRG_B 0.47 0.22 1.00 7 3479 0 0 0 0 25

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.