CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(20) - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(20) & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric Multilign(20) Mastr(seed)
MCC 0.561 > 0.000
Average MCC ± 95% Confidence Intervals 0.556 ± 0.161 > 0.000 ± 0.000
Sensitivity 0.466 > 0.000
Positive Predictive Value 0.682 > 0.000
Total TP 242 > 0
Total TN 64967 < 65322
Total FP 123 > 0
Total FP CONTRA 10 > 0
Total FP INCONS 103 > 0
Total FP COMP 10 > 0
Total FN 277 < 519
P-value 1.77512146924e-08

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Performance plots


  1. Comparison of performance of Multilign(20) and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and Mastr(seed)).

  2. Comparison of performance of Multilign(20) and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and Mastr(seed)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Multilign(20) and Mastr(seed)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Multilign(20) and Mastr(seed)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and Mastr(seed)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and Mastr(seed)).

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Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 242
Total TN 64967
Total FP 123
Total FP CONTRA 10
Total FP INCONS 103
Total FP COMP 10
Total FN 277
Total Scores
MCC 0.561
Average MCC ± 95% Confidence Intervals 0.556 ± 0.161
Sensitivity 0.466
Positive Predictive Value 0.682
Nr of predictions 15

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2XXA_G 0.00 0.00 0.00 0 5139 12 1 11 0 42
3AMU_B 0.63 0.56 0.71 15 2982 8 0 6 2 12
3J20_0 0.61 0.53 0.70 16 2827 8 1 6 1 14
3J20_1 0.96 0.91 1.00 21 2905 0 0 0 0 2
3J2L_3 0.65 0.53 0.80 28 7840 9 0 7 2 25
3RKF_A 0.77 0.62 0.95 21 2189 1 0 1 0 13
3SD1_A 0.57 0.48 0.69 20 3887 9 1 8 0 22
3ZEX_D 0.75 0.65 0.86 32 6984 5 1 4 0 17
4A1C_3 0.70 0.59 0.84 32 7102 6 0 6 0 22
4A1C_2 0.15 0.15 0.15 5 11747 33 3 26 4 28
4AOB_A 0.49 0.38 0.64 16 4346 10 1 8 1 26
4ENB_A 0.34 0.26 0.45 5 1264 6 1 5 0 14
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10
4FRG_B 0.12 0.09 0.17 3 3468 15 0 15 0 29

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 0
Total TN 65322
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 519
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 15

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.00 0.00 0.00 0 990 0 0 0 0 20
2XXA_G 0.00 0.00 0.00 0 5151 0 0 0 0 42
3AMU_B 0.00 0.00 0.00 0 3003 0 0 0 0 27
3J20_0 0.00 0.00 0.00 0 2850 0 0 0 0 30
3J20_1 0.00 0.00 0.00 0 2926 0 0 0 0 23
3J2L_3 0.00 0.00 0.00 0 7875 0 0 0 0 53
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
3ZEX_D 0.00 0.00 0.00 0 7021 0 0 0 0 49
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.