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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & Multilign(20) [.zip] - may take several seconds...


Overview

Metric Multilign(seed) Multilign(20)
MCC 0.678 > 0.661
Average MCC ± 95% Confidence Intervals 0.711 ± 0.265 > 0.700 ± 0.344
Sensitivity 0.543 < 0.551
Positive Predictive Value 0.852 > 0.800
Total TP 75 < 76
Total TN 11400 > 11393
Total FP 14 < 20
Total FP CONTRA 1 < 2
Total FP INCONS 12 < 17
Total FP COMP 1 = 1
Total FN 63 > 62
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and Multilign(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and Multilign(20)).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 11400
Total FP 14
Total FP CONTRA 1
Total FP INCONS 12
Total FP COMP 1
Total FN 63
Total Scores
MCC 0.678
Average MCC ± 95% Confidence Intervals 0.711 ± 0.265
Sensitivity 0.543
Positive Predictive Value 0.852
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.92 0.85 1.00 17 973 0 0 0 0 3
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 76
Total TN 11393
Total FP 20
Total FP CONTRA 2
Total FP INCONS 17
Total FP COMP 1
Total FN 62
Total Scores
MCC 0.661
Average MCC ± 95% Confidence Intervals 0.700 ± 0.344
Sensitivity 0.551
Positive Predictive Value 0.800
Nr of predictions 4

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
3RKF_A 0.77 0.62 0.95 21 2189 1 0 1 0 13
3SD1_A 0.57 0.48 0.69 20 3887 9 1 8 0 22
4AOB_A 0.49 0.38 0.64 16 4346 10 1 8 1 26

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.