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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & NanoFolder [.zip] - may take several seconds...


Overview

Metric Multilign(seed) NanoFolder
MCC 0.586 > 0.302
Average MCC ± 95% Confidence Intervals 0.478 ± 1.088 > 0.338 ± 0.435
Sensitivity 0.471 > 0.294
Positive Predictive Value 0.738 > 0.323
Total TP 48 > 30
Total TN 10599 > 10571
Total FP 19 < 65
Total FP CONTRA 1 < 2
Total FP INCONS 16 < 61
Total FP COMP 2 = 2
Total FN 54 < 72
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and NanoFolder).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 48
Total TN 10599
Total FP 19
Total FP CONTRA 1
Total FP INCONS 16
Total FP COMP 2
Total FN 54
Total Scores
MCC 0.586
Average MCC ± 95% Confidence Intervals 0.478 ± 1.088
Sensitivity 0.471
Positive Predictive Value 0.738
Nr of predictions 3

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3W3S_B 0.84 0.73 0.97 29 4723 2 0 1 1 11
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 30
Total TN 10571
Total FP 65
Total FP CONTRA 2
Total FP INCONS 61
Total FP COMP 2
Total FN 72
Total Scores
MCC 0.302
Average MCC ± 95% Confidence Intervals 0.338 ± 0.435
Sensitivity 0.294
Positive Predictive Value 0.323
Nr of predictions 3

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.52 0.55 0.50 11 1518 11 0 11 0 9
3W3S_B 0.17 0.18 0.18 7 4713 34 1 32 1 33
4AOB_A 0.33 0.29 0.39 12 4340 20 1 18 1 30

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.