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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of RNASLOpt - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & RNASLOpt [.zip] - may take several seconds...


Overview

Metric Multilign(seed) RNASLOpt
MCC 0.477 > 0.400
Average MCC ± 95% Confidence Intervals 0.414 ± 0.406 > 0.404 ± 0.315
Sensitivity 0.358 > 0.316
Positive Predictive Value 0.642 > 0.513
Total TP 68 > 60
Total TN 29905 > 29894
Total FP 40 < 71
Total FP CONTRA 5 < 6
Total FP INCONS 33 < 51
Total FP COMP 2 < 14
Total FN 122 < 130
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and RNASLOpt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and RNASLOpt).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and RNASLOpt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and RNASLOpt).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 68
Total TN 29905
Total FP 40
Total FP CONTRA 5
Total FP INCONS 33
Total FP COMP 2
Total FN 122
Total Scores
MCC 0.477
Average MCC ± 95% Confidence Intervals 0.414 ± 0.406
Sensitivity 0.358
Positive Predictive Value 0.642
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3W3S_B 0.84 0.73 0.97 29 4723 2 0 1 1 11
3ZEX_C 0.39 0.27 0.58 14 14172 10 3 7 0 38
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23
4FRN_A 0.24 0.17 0.35 6 5134 11 1 10 0 30

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Performance of RNASLOpt - scored lower in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP 60
Total TN 29894
Total FP 71
Total FP CONTRA 6
Total FP INCONS 51
Total FP COMP 14
Total FN 130
Total Scores
MCC 0.400
Average MCC ± 95% Confidence Intervals 0.404 ± 0.315
Sensitivity 0.316
Positive Predictive Value 0.513
Nr of predictions 5

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.47 0.35 0.64 7 1529 4 0 4 0 13
3W3S_B 0.82 0.70 0.97 28 4724 2 0 1 1 12
3ZEX_C 0.26 0.21 0.33 11 14163 35 2 20 13 41
4AOB_A 0.26 0.19 0.38 8 4350 13 2 11 0 34
4FRN_A 0.20 0.17 0.26 6 5128 17 2 15 0 30

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.