CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of RNASampler(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & RNASampler(seed) [.zip] - may take several seconds...


Overview

Metric Multilign(seed) RNASampler(seed)
MCC 0.597 > 0.502
Average MCC ± 95% Confidence Intervals 0.576 ± 0.363 > 0.487 ± 0.303
Sensitivity 0.476 > 0.332
Positive Predictive Value 0.756 < 0.767
Total TP 99 > 69
Total TN 27475 < 27516
Total FP 33 > 26
Total FP CONTRA 5 > 1
Total FP INCONS 27 > 20
Total FP COMP 1 < 5
Total FN 109 < 139
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and RNASampler(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and RNASampler(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and RNASampler(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and RNASampler(seed)).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 99
Total TN 27475
Total FP 33
Total FP CONTRA 5
Total FP INCONS 27
Total FP COMP 1
Total FN 109
Total Scores
MCC 0.597
Average MCC ± 95% Confidence Intervals 0.576 ± 0.363
Sensitivity 0.476
Positive Predictive Value 0.756
Nr of predictions 6

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.92 0.85 1.00 17 973 0 0 0 0 3
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
3W3S_B 0.84 0.73 0.97 29 4723 2 0 1 1 11
3ZEX_C 0.39 0.27 0.58 14 14172 10 3 7 0 38

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Performance of RNASampler(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(seed)

Total Base Pair Counts
Total TP 69
Total TN 27516
Total FP 26
Total FP CONTRA 1
Total FP INCONS 20
Total FP COMP 5
Total FN 139
Total Scores
MCC 0.502
Average MCC ± 95% Confidence Intervals 0.487 ± 0.303
Sensitivity 0.332
Positive Predictive Value 0.767
Nr of predictions 6

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2. Individual counts for RNASampler(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.71 0.55 0.92 11 978 1 0 1 0 9
2LC8_A -0.01 0.00 0.00 0 1530 10 0 10 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.60 0.38 0.94 16 3899 1 0 1 0 26
3W3S_B 0.55 0.30 1.00 12 4741 1 0 0 1 28
3ZEX_C 0.32 0.19 0.53 10 14177 13 1 8 4 42

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.