CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of RNAalifold(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & RNAalifold(20) [.zip] - may take several seconds...


Overview

Metric Multilign(seed) RNAalifold(20)
MCC 0.608 > 0.601
Average MCC ± 95% Confidence Intervals 0.648 ± 0.251 > 0.606 ± 0.178
Sensitivity 0.468 > 0.463
Positive Predictive Value 0.795 > 0.786
Total TP 89 > 88
Total TN 25572 = 25572
Total FP 24 < 28
Total FP CONTRA 4 > 2
Total FP INCONS 19 < 22
Total FP COMP 1 < 4
Total FN 101 < 102
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and RNAalifold(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and RNAalifold(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and RNAalifold(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and RNAalifold(20)).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 89
Total TN 25572
Total FP 24
Total FP CONTRA 4
Total FP INCONS 19
Total FP COMP 1
Total FN 101
Total Scores
MCC 0.608
Average MCC ± 95% Confidence Intervals 0.648 ± 0.251
Sensitivity 0.468
Positive Predictive Value 0.795
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.92 0.85 1.00 17 973 0 0 0 0 3
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
3ZEX_C 0.39 0.27 0.58 14 14172 10 3 7 0 38
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Performance of RNAalifold(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNAalifold(20)

Total Base Pair Counts
Total TP 88
Total TN 25572
Total FP 28
Total FP CONTRA 2
Total FP INCONS 22
Total FP COMP 4
Total FN 102
Total Scores
MCC 0.601
Average MCC ± 95% Confidence Intervals 0.606 ± 0.178
Sensitivity 0.463
Positive Predictive Value 0.786
Nr of predictions 5

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2. Individual counts for RNAalifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.53 0.50 0.59 10 973 7 0 7 0 10
3RKF_A 0.68 0.50 0.94 17 2193 1 0 1 0 17
3SD1_A 0.70 0.60 0.83 25 3886 5 1 4 0 17
3ZEX_C 0.39 0.27 0.56 14 14171 14 1 10 3 38
4AOB_A 0.72 0.52 1.00 22 4349 1 0 0 1 20

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.