CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(20) - scored higher in this pairwise comparison

  4. Performance of Cylofold - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(20) & Cylofold [.zip] - may take several seconds...


Overview

Metric Murlet(20) Cylofold
MCC 0.638 > 0.616
Average MCC ± 95% Confidence Intervals 0.607 ± 0.088 < 0.645 ± 0.106
Sensitivity 0.481 < 0.528
Positive Predictive Value 0.851 > 0.725
Total TP 326 < 358
Total TN 92874 > 92763
Total FP 69 < 163
Total FP CONTRA 4 < 22
Total FP INCONS 53 < 114
Total FP COMP 12 < 27
Total FN 352 > 320
P-value 2.69132796717e-08

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Performance plots


  1. Comparison of performance of Murlet(20) and Cylofold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and Cylofold).

  2. Comparison of performance of Murlet(20) and Cylofold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and Cylofold).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and Cylofold).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and Cylofold).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and Cylofold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and Cylofold).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and Cylofold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and Cylofold).

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Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 326
Total TN 92874
Total FP 69
Total FP CONTRA 4
Total FP INCONS 53
Total FP COMP 12
Total FN 352
Total Scores
MCC 0.638
Average MCC ± 95% Confidence Intervals 0.607 ± 0.088
Sensitivity 0.481
Positive Predictive Value 0.851
Nr of predictions 19

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.53 0.50 0.59 10 973 7 0 7 0 10
2XKV_B 0.45 0.20 1.00 4 4556 3 0 0 3 16
2XQD_Y 0.80 0.70 0.90 19 2829 2 0 2 0 8
2XXA_G 0.41 0.17 1.00 7 5144 0 0 0 0 35
3AMU_B 0.77 0.67 0.90 18 2983 3 0 2 1 9
3IZF_C 0.71 0.56 0.91 30 6870 4 0 3 1 24
3J20_0 0.58 0.47 0.74 14 2831 5 0 5 0 16
3J20_1 0.68 0.57 0.81 13 2910 3 0 3 0 10
3J2L_3 0.69 0.49 0.96 26 7848 3 0 1 2 27
3O58_3 0.33 0.23 0.47 8 12386 12 2 7 3 27
3O58_2 0.89 0.82 0.97 31 7228 2 0 1 1 7
3PDR_A 0.70 0.53 0.93 38 12839 3 0 3 0 34
3RKF_A 0.68 0.47 1.00 16 2195 0 0 0 0 18
3SD1_A 0.68 0.57 0.83 24 3887 5 1 4 0 18
3ZEX_D 0.77 0.65 0.91 32 6986 3 0 3 0 17
4AOB_A 0.72 0.55 0.96 23 4347 2 0 1 1 19
4ENB_A 0.46 0.21 1.00 4 1271 0 0 0 0 15
4ENC_A 0.51 0.26 1.00 5 1321 0 0 0 0 14
4FRG_B 0.17 0.13 0.25 4 3470 12 1 11 0 28

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Performance of Cylofold - scored lower in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 358
Total TN 92763
Total FP 163
Total FP CONTRA 22
Total FP INCONS 114
Total FP COMP 27
Total FN 320
Total Scores
MCC 0.616
Average MCC ± 95% Confidence Intervals 0.645 ± 0.106
Sensitivity 0.528
Positive Predictive Value 0.725
Nr of predictions 19

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2XKV_B 0.38 0.40 0.36 8 4538 23 7 7 9 12
2XQD_Y 0.81 0.78 0.84 21 2825 4 4 0 0 6
2XXA_G 0.10 0.10 0.11 4 5115 32 1 31 0 38
3AMU_B 0.67 0.59 0.76 16 2982 7 0 5 2 11
3IZF_C 0.68 0.56 0.83 30 6867 6 0 6 0 24
3J20_0 0.66 0.57 0.77 17 2828 6 1 4 1 13
3J20_1 0.69 0.70 0.70 16 2903 7 2 5 0 7
3J2L_3 0.56 0.43 0.72 23 7843 11 0 9 2 30
3O58_3 0.36 0.34 0.38 12 12371 29 5 15 9 23
3O58_2 0.80 0.68 0.93 26 7232 3 0 2 1 12
3PDR_A 0.72 0.54 0.95 39 12839 4 0 2 2 33
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.62 0.50 0.78 21 3889 6 0 6 0 21
3ZEX_D 0.58 0.49 0.69 24 6986 11 0 11 0 25
4AOB_A 0.35 0.26 0.48 11 4348 13 1 11 1 31
4ENB_A 0.89 0.79 1.00 15 1260 0 0 0 0 4
4ENC_A 0.86 0.79 0.94 15 1310 1 1 0 0 4
4FRG_B 0.81 0.66 1.00 21 3465 0 0 0 0 11

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.