CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(20) - scored higher in this pairwise comparison

  4. Performance of RNAwolf - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(20) & RNAwolf [.zip] - may take several seconds...


Overview

Metric Murlet(20) RNAwolf
MCC 0.583 > 0.348
Average MCC ± 95% Confidence Intervals 0.565 ± 0.090 > 0.375 ± 0.099
Sensitivity 0.437 > 0.328
Positive Predictive Value 0.784 > 0.379
Total TP 345 > 259
Total TN 119885 > 119641
Total FP 117 < 467
Total FP CONTRA 6 < 53
Total FP INCONS 89 < 372
Total FP COMP 22 < 42
Total FN 445 < 531
P-value 5.1503931209e-08

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Performance plots


  1. Comparison of performance of Murlet(20) and RNAwolf. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and RNAwolf).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and RNAwolf).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and RNAwolf. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and RNAwolf).

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Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 345
Total TN 119885
Total FP 117
Total FP CONTRA 6
Total FP INCONS 89
Total FP COMP 22
Total FN 445
Total Scores
MCC 0.583
Average MCC ± 95% Confidence Intervals 0.565 ± 0.090
Sensitivity 0.437
Positive Predictive Value 0.784
Nr of predictions 21

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3AMU_B 0.77 0.67 0.90 18 2983 3 0 2 1 9
3J20_1 0.68 0.57 0.81 13 2910 3 0 3 0 10
3J20_0 0.58 0.47 0.74 14 2831 5 0 5 0 16
3J2L_3 0.69 0.49 0.96 26 7848 3 0 1 2 27
3J3D_C 0.78 0.64 0.95 18 2756 1 0 1 0 10
3J3E_8 0.24 0.15 0.38 5 7490 13 1 7 5 28
3J3E_7 0.77 0.63 0.94 34 7104 2 0 2 0 20
3J3F_8 0.48 0.36 0.65 13 12226 10 0 7 3 23
3J3F_7 0.69 0.50 0.96 25 7234 1 0 1 0 25
3J3V_B 0.63 0.40 1.00 23 6998 0 0 0 0 34
3RKF_A 0.68 0.47 1.00 16 2195 0 0 0 0 18
3SD1_A 0.68 0.57 0.83 24 3887 5 1 4 0 18
3ZEX_D 0.77 0.65 0.91 32 6986 3 0 3 0 17
3ZEX_C 0.34 0.23 0.50 12 14172 15 1 11 3 40
3ZND_W 0.45 0.39 0.53 9 2986 11 0 8 3 14
4A1C_3 0.59 0.41 0.85 22 7114 4 0 4 0 32
4A1C_2 0.17 0.15 0.20 5 11756 24 2 18 4 28
4AOB_A 0.72 0.55 0.96 23 4347 2 0 1 1 19
4ENB_A 0.46 0.21 1.00 4 1271 0 0 0 0 15
4ENC_A 0.51 0.26 1.00 5 1321 0 0 0 0 14
4FRG_B 0.17 0.13 0.25 4 3470 12 1 11 0 28

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Performance of RNAwolf - scored lower in this pairwise comparison

1. Total counts & total scores for RNAwolf

Total Base Pair Counts
Total TP 259
Total TN 119641
Total FP 467
Total FP CONTRA 53
Total FP INCONS 372
Total FP COMP 42
Total FN 531
Total Scores
MCC 0.348
Average MCC ± 95% Confidence Intervals 0.375 ± 0.099
Sensitivity 0.328
Positive Predictive Value 0.379
Nr of predictions 21

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2. Individual counts for RNAwolf [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3AMU_B 0.68 0.63 0.74 17 2980 9 0 6 3 10
3J20_1 0.46 0.52 0.41 12 2897 17 6 11 0 11
3J20_0 0.40 0.40 0.41 12 2821 18 0 17 1 18
3J2L_3 0.55 0.49 0.62 26 7833 18 0 16 2 27
3J3D_C 0.79 0.75 0.84 21 2750 5 2 2 1 7
3J3E_8 0.00 0.00 0.00 0 7470 42 4 29 9 33
3J3E_7 0.41 0.35 0.49 19 7101 20 1 19 0 35
3J3F_8 0.23 0.25 0.21 9 12204 45 5 28 12 27
3J3F_7 0.21 0.20 0.23 10 7216 34 2 32 0 40
3J3V_B 0.43 0.37 0.51 21 6980 20 2 18 0 36
3RKF_A 0.72 0.62 0.84 21 2186 4 0 4 0 13
3SD1_A 0.46 0.43 0.50 18 3880 18 0 18 0 24
3ZEX_D 0.20 0.18 0.22 9 6980 32 3 29 0 40
3ZEX_C 0.05 0.06 0.06 3 14144 49 12 37 0 49
3ZND_W 0.50 0.48 0.52 11 2982 13 0 10 3 12
4A1C_3 0.23 0.20 0.28 11 7101 28 2 26 0 43
4A1C_2 0.08 0.09 0.08 3 11741 46 10 27 9 30
4AOB_A 0.23 0.19 0.30 8 4344 20 1 18 1 34
4ENB_A 0.35 0.32 0.40 6 1260 9 1 8 0 13
4ENC_A 0.34 0.32 0.38 6 1310 10 1 9 0 13
4FRG_B 0.56 0.50 0.64 16 3461 10 1 8 1 16

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.