CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(seed) - scored higher in this pairwise comparison

  4. Performance of RDfolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(seed) & RDfolder [.zip] - may take several seconds...


Overview

Metric Murlet(seed) RDfolder
MCC 0.578 > 0.569
Average MCC ± 95% Confidence Intervals 0.578 ± 0.084 < 0.588 ± 0.154
Sensitivity 0.397 < 0.464
Positive Predictive Value 0.851 > 0.707
Total TP 223 < 261
Total TN 47808 > 47701
Total FP 43 < 112
Total FP CONTRA 4 < 12
Total FP INCONS 35 < 96
Total FP COMP 4 = 4
Total FN 339 > 301
P-value 1.1934089898e-05

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Performance plots


  1. Comparison of performance of Murlet(seed) and RDfolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(seed) and RDfolder).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(seed) and RDfolder).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(seed) and RDfolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(seed) and RDfolder).

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Performance of Murlet(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 223
Total TN 47808
Total FP 43
Total FP CONTRA 4
Total FP INCONS 35
Total FP COMP 4
Total FN 339
Total Scores
MCC 0.578
Average MCC ± 95% Confidence Intervals 0.578 ± 0.084
Sensitivity 0.397
Positive Predictive Value 0.851
Nr of predictions 21

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.52 0.27 1.00 3 403 0 0 0 0 8
2KE6_A 0.66 0.53 0.83 10 1116 2 0 2 0 9
2KUR_A 0.63 0.48 0.83 10 1116 2 0 2 0 11
2KUU_A 0.63 0.48 0.83 10 1116 2 0 2 0 11
2KUV_A 0.85 0.73 1.00 16 1112 0 0 0 0 6
2KUW_A 0.84 0.76 0.94 16 1111 1 0 1 0 5
2L1F_A 0.82 0.75 0.90 18 2060 2 0 2 0 6
2L1F_B 0.80 0.72 0.90 18 2125 2 0 2 0 7
2L94_A 0.59 0.40 0.89 8 981 1 0 1 0 12
2LC8_A -0.01 0.00 0.00 0 1528 12 0 12 0 20
2XKV_B 0.45 0.20 1.00 4 4556 2 0 0 2 16
3A3A_A 0.57 0.32 1.00 12 3643 0 0 0 0 25
3GX2_A 0.59 0.35 1.00 14 4357 1 0 0 1 26
3IVN_B 0.53 0.39 0.75 12 2330 4 2 2 0 19
3LA5_A 0.58 0.41 0.82 14 2468 3 1 2 0 20
3RKF_A 0.53 0.35 0.80 12 2196 3 1 2 0 22
3SD1_A 0.47 0.26 0.85 11 3903 2 0 2 0 31
3W3S_B 0.41 0.23 0.75 9 4741 3 0 3 0 31
4AOB_A 0.58 0.33 1.00 14 4357 1 0 0 1 28
4ENB_A 0.56 0.32 1.00 6 1269 0 0 0 0 13
4ENC_A 0.56 0.32 1.00 6 1320 0 0 0 0 13

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Performance of RDfolder - scored lower in this pairwise comparison

1. Total counts & total scores for RDfolder

Total Base Pair Counts
Total TP 261
Total TN 47701
Total FP 112
Total FP CONTRA 12
Total FP INCONS 96
Total FP COMP 4
Total FN 301
Total Scores
MCC 0.569
Average MCC ± 95% Confidence Intervals 0.588 ± 0.154
Sensitivity 0.464
Positive Predictive Value 0.707
Nr of predictions 21

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2. Individual counts for RDfolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.89 0.79 1.00 15 1113 1 0 0 1 4
2KUR_A 0.87 0.76 1.00 16 1112 0 0 0 0 5
2KUU_A 0.84 0.71 1.00 15 1113 1 0 0 1 6
2KUV_A 0.85 0.73 1.00 16 1112 0 0 0 0 6
2KUW_A 0.87 0.76 1.00 16 1112 0 0 0 0 5
2L1F_A -0.01 0.00 0.00 0 2067 13 2 11 0 24
2L1F_B 0.98 0.96 1.00 24 2121 0 0 0 0 1
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LC8_A -0.01 0.00 0.00 0 1526 14 2 12 0 20
2XKV_B 0.00 0.00 0.00 0 4538 22 5 17 0 20
3A3A_A 0.53 0.41 0.71 15 3634 6 0 6 0 22
3GX2_A 0.50 0.40 0.64 16 4346 10 1 8 1 24
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.30 0.17 0.54 7 3903 6 0 6 0 35
3W3S_B 0.27 0.23 0.33 9 4726 18 1 17 0 31
4AOB_A 0.35 0.26 0.48 11 4348 13 1 11 1 31
4ENB_A 0.43 0.32 0.60 6 1265 4 0 4 0 13
4ENC_A 0.43 0.32 0.60 6 1316 4 0 4 0 13

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.