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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_2.0(seed) - scored higher in this pairwise comparison

  4. Performance of CentroidAlifold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_2.0(seed) & CentroidAlifold(seed) [.zip] - may take several seconds...


Overview

Metric PETfold_2.0(seed) CentroidAlifold(seed)
MCC 0.769 > 0.618
Average MCC ± 95% Confidence Intervals 0.771 ± 0.133 > 0.632 ± 1.873
Sensitivity 0.642 > 0.432
Positive Predictive Value 0.924 > 0.891
Total TP 61 > 41
Total TN 11141 < 11161
Total FP 7 > 5
Total FP CONTRA 1 = 1
Total FP INCONS 4 = 4
Total FP COMP 2 > 0
Total FN 34 < 54
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_2.0(seed) and CentroidAlifold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_2.0(seed) and CentroidAlifold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_2.0(seed) and CentroidAlifold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_2.0(seed) and CentroidAlifold(seed)).

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Performance of PETfold_2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_2.0(seed)

Total Base Pair Counts
Total TP 61
Total TN 11141
Total FP 7
Total FP CONTRA 1
Total FP INCONS 4
Total FP COMP 2
Total FN 34
Total Scores
MCC 0.769
Average MCC ± 95% Confidence Intervals 0.771 ± 0.133
Sensitivity 0.642
Positive Predictive Value 0.924
Nr of predictions 2

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2. Individual counts for PETfold_2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3V_B 0.76 0.61 0.95 35 6984 3 0 2 1 22
3W1K_J 0.78 0.68 0.90 26 4157 4 1 2 1 12

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Performance of CentroidAlifold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

Total Base Pair Counts
Total TP 41
Total TN 11161
Total FP 5
Total FP CONTRA 1
Total FP INCONS 4
Total FP COMP 0
Total FN 54
Total Scores
MCC 0.618
Average MCC ± 95% Confidence Intervals 0.632 ± 1.873
Sensitivity 0.432
Positive Predictive Value 0.891
Nr of predictions 2

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2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3V_B 0.48 0.28 0.84 16 7002 3 0 3 0 41
3W1K_J 0.78 0.66 0.93 25 4159 2 1 1 0 13

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.