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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

  4. Performance of MXScarna(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(20) & MXScarna(20) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(20) MXScarna(20)
MCC 0.649 > 0.570
Average MCC ± 95% Confidence Intervals 0.630 ± 0.114 > 0.551 ± 0.113
Sensitivity 0.530 > 0.470
Positive Predictive Value 0.798 > 0.696
Total TP 364 > 323
Total TN 110739 > 110731
Total FP 120 < 185
Total FP CONTRA 4 < 21
Total FP INCONS 88 < 120
Total FP COMP 28 < 44
Total FN 323 < 364
P-value 2.54914456376e-08

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(20) and MXScarna(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(20) and MXScarna(20)).

  2. Comparison of performance of PETfold_pre2.0(20) and MXScarna(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(20) and MXScarna(20)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(20) and MXScarna(20)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(20) and MXScarna(20)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(20) and MXScarna(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(20) and MXScarna(20)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(20) and MXScarna(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(20) and MXScarna(20)).

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Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(20)

Total Base Pair Counts
Total TP 364
Total TN 110739
Total FP 120
Total FP CONTRA 4
Total FP INCONS 88
Total FP COMP 28
Total FN 323
Total Scores
MCC 0.649
Average MCC ± 95% Confidence Intervals 0.630 ± 0.114
Sensitivity 0.530
Positive Predictive Value 0.798
Nr of predictions 18

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2. Individual counts for PETfold_pre2.0(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 0.96 0.91 1.00 21 2905 0 0 0 0 2
3J20_0 0.84 0.70 1.00 21 2829 0 0 0 0 9
3J2L_3 0.78 0.62 0.97 33 7841 3 0 1 2 20
3J3D_C 0.80 0.68 0.95 19 2755 1 0 1 0 9
3J3E_8 0.32 0.21 0.50 7 7489 11 0 7 4 26
3J3E_7 0.74 0.63 0.87 34 7101 5 1 4 0 20
3J3F_8 0.30 0.25 0.38 9 12222 22 0 15 7 27
3J3F_7 0.78 0.68 0.89 34 7222 5 1 3 1 16
3J3V_B 0.65 0.51 0.83 29 6986 6 1 5 0 28
3ZEX_D 0.81 0.71 0.92 35 6983 3 0 3 0 14
3ZEX_C 0.24 0.17 0.35 9 14170 18 0 17 1 43
3ZND_W 0.47 0.43 0.53 10 2984 11 0 9 2 13
4A1C_2 0.19 0.15 0.25 5 11761 25 0 15 10 28
4A1C_3 0.82 0.69 0.97 37 7102 1 0 1 0 17
4AOB_A 0.74 0.60 0.93 25 4344 3 0 2 1 17
4ENB_A 0.61 0.42 0.89 8 1266 1 0 1 0 11
4ENC_A 0.55 0.42 0.73 8 1315 3 0 3 0 11
4FRG_B 0.75 0.63 0.91 20 3464 2 1 1 0 12

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Performance of MXScarna(20) - scored lower in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP 323
Total TN 110731
Total FP 185
Total FP CONTRA 21
Total FP INCONS 120
Total FP COMP 44
Total FN 364
Total Scores
MCC 0.570
Average MCC ± 95% Confidence Intervals 0.551 ± 0.113
Sensitivity 0.470
Positive Predictive Value 0.696
Nr of predictions 18

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 0.93 0.87 1.00 20 2906 0 0 0 0 3
3J20_0 0.82 0.67 1.00 20 2830 0 0 0 0 10
3J2L_3 0.54 0.42 0.71 22 7844 11 1 8 2 31
3J3D_C 0.82 0.71 0.95 20 2754 1 0 1 0 8
3J3E_8 0.14 0.09 0.23 3 7490 15 2 8 5 30
3J3E_7 0.61 0.54 0.69 29 7098 13 2 11 0 25
3J3F_8 0.43 0.36 0.52 13 12221 26 2 10 14 23
3J3F_7 0.66 0.60 0.73 30 7219 12 1 10 1 20
3J3V_B 0.74 0.61 0.90 35 6982 4 1 3 0 22
3ZEX_D 0.68 0.63 0.74 31 6979 11 2 9 0 18
3ZEX_C 0.31 0.21 0.46 11 14172 13 2 11 0 41
3ZND_W 0.37 0.35 0.40 8 2983 15 2 10 3 15
4A1C_2 0.18 0.15 0.21 5 11757 36 2 17 17 28
4A1C_3 0.64 0.56 0.75 30 7100 11 2 8 1 24
4AOB_A 0.62 0.55 0.72 23 4339 10 0 9 1 19
4ENB_A 0.26 0.11 0.67 2 1272 1 0 1 0 17
4ENC_A 0.60 0.37 1.00 7 1319 0 0 0 0 12
4FRG_B 0.55 0.44 0.70 14 3466 6 2 4 0 18

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.