CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of Carnac(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & Carnac(20) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) Carnac(20)
MCC 0.719 > 0.547
Average MCC ± 95% Confidence Intervals 0.696 ± 0.078 > 0.477 ± 0.132
Sensitivity 0.597 > 0.351
Positive Predictive Value 0.870 > 0.858
Total TP 410 > 241
Total TN 110724 < 110914
Total FP 88 > 47
Total FP CONTRA 4 > 2
Total FP INCONS 57 > 38
Total FP COMP 27 > 7
Total FN 277 < 446
P-value 2.66715895098e-08

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and Carnac(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Carnac(20)).

  2. Comparison of performance of PETfold_pre2.0(seed) and Carnac(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Carnac(20)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Carnac(20)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Carnac(20)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and Carnac(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Carnac(20)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and Carnac(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Carnac(20)).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 410
Total TN 110724
Total FP 88
Total FP CONTRA 4
Total FP INCONS 57
Total FP COMP 27
Total FN 277
Total Scores
MCC 0.719
Average MCC ± 95% Confidence Intervals 0.696 ± 0.078
Sensitivity 0.597
Positive Predictive Value 0.870
Nr of predictions 18

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 0.96 0.91 1.00 21 2905 1 0 0 1 2
3J20_0 0.84 0.70 1.00 21 2829 1 0 0 1 9
3J2L_3 0.77 0.62 0.94 33 7840 4 0 2 2 20
3J3D_C 0.82 0.71 0.95 20 2754 2 0 1 1 8
3J3E_8 0.43 0.30 0.63 10 7487 8 0 6 2 23
3J3E_7 0.78 0.67 0.92 36 7101 3 0 3 0 18
3J3F_8 0.63 0.53 0.76 19 12221 10 0 6 4 17
3J3F_7 0.85 0.74 0.97 37 7222 2 0 1 1 13
3J3V_B 0.76 0.61 0.95 35 6984 3 0 2 1 22
3ZEX_D 0.82 0.73 0.92 36 6982 3 0 3 0 13
3ZEX_C 0.53 0.37 0.76 19 14171 10 1 5 4 33
3ZND_W 0.47 0.43 0.53 10 2984 12 0 9 3 13
4A1C_2 0.57 0.45 0.71 15 11760 12 0 6 6 18
4A1C_3 0.83 0.70 0.97 38 7101 1 0 1 0 16
4AOB_A 0.72 0.57 0.92 24 4345 3 0 2 1 18
4ENB_A 0.50 0.42 0.62 8 1262 5 1 4 0 11
4ENC_A 0.50 0.42 0.62 8 1313 5 1 4 0 11
4FRG_B 0.74 0.63 0.87 20 3463 3 1 2 0 12

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Performance of Carnac(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 241
Total TN 110914
Total FP 47
Total FP CONTRA 2
Total FP INCONS 38
Total FP COMP 7
Total FN 446
Total Scores
MCC 0.547
Average MCC ± 95% Confidence Intervals 0.477 ± 0.132
Sensitivity 0.351
Positive Predictive Value 0.858
Nr of predictions 18

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 0.86 0.74 1.00 17 2909 0 0 0 0 6
3J20_0 0.62 0.53 0.73 16 2828 7 0 6 1 14
3J2L_3 0.46 0.34 0.64 18 7847 11 0 10 1 35
3J3D_C 0.82 0.71 0.95 20 2754 1 0 1 0 8
3J3E_8 0.00 0.00 0.00 0 7503 0 0 0 0 33
3J3E_7 0.65 0.44 0.96 24 7115 1 0 1 0 30
3J3F_8 0.50 0.25 1.00 9 12237 0 0 0 0 27
3J3F_7 0.66 0.44 1.00 22 7238 0 0 0 0 28
3J3V_B 0.58 0.35 0.95 20 7000 1 0 1 0 37
3ZEX_D 0.73 0.53 1.00 26 6995 0 0 0 0 23
3ZEX_C 0.31 0.13 0.70 7 14186 3 1 2 0 45
3ZND_W 0.47 0.39 0.56 9 2987 10 0 7 3 14
4A1C_2 0.33 0.15 0.71 5 11774 3 0 2 1 28
4A1C_3 0.67 0.52 0.88 28 7108 4 0 4 0 26
4AOB_A 0.49 0.33 0.74 14 4352 6 1 4 1 28
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.43 0.19 1.00 6 3480 0 0 0 0 26

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.