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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of MaxExpect - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & MaxExpect [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) MaxExpect
MCC 0.715 > 0.509
Average MCC ± 95% Confidence Intervals 0.699 ± 0.059 > 0.497 ± 0.101
Sensitivity 0.602 > 0.439
Positive Predictive Value 0.850 > 0.592
Total TP 935 > 682
Total TN 1251685 > 1251632
Total FP 203 < 525
Total FP CONTRA 18 < 35
Total FP INCONS 147 < 436
Total FP COMP 38 < 54
Total FN 617 < 870
P-value 5.23657817852e-08

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and MaxExpect. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and MaxExpect).

  2. Comparison of performance of PETfold_pre2.0(seed) and MaxExpect. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and MaxExpect).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and MaxExpect).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and MaxExpect).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and MaxExpect. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and MaxExpect).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and MaxExpect. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and MaxExpect).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 935
Total TN 1251685
Total FP 203
Total FP CONTRA 18
Total FP INCONS 147
Total FP COMP 38
Total FN 617
Total Scores
MCC 0.715
Average MCC ± 95% Confidence Intervals 0.699 ± 0.059
Sensitivity 0.602
Positive Predictive Value 0.850
Nr of predictions 26

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.40 0.30 0.55 6 1529 5 0 5 0 14
3J16_L 0.82 0.70 0.95 21 2753 1 0 1 0 9
3J20_1 0.96 0.91 1.00 21 2905 1 0 0 1 2
3J20_2 0.71 0.61 0.81 388 1116287 97 10 80 7 245
3J20_0 0.84 0.70 1.00 21 2829 1 0 0 1 9
3J2L_3 0.77 0.62 0.94 33 7840 4 0 2 2 20
3J3D_C 0.82 0.71 0.95 20 2754 2 0 1 1 8
3J3E_8 0.43 0.30 0.63 10 7487 8 0 6 2 23
3J3E_7 0.78 0.67 0.92 36 7101 3 0 3 0 18
3J3F_8 0.63 0.53 0.76 19 12221 10 0 6 4 17
3J3F_7 0.85 0.74 0.97 37 7222 2 0 1 1 13
3J3V_B 0.76 0.61 0.95 35 6984 3 0 2 1 22
3UZL_B 0.72 0.54 0.95 20 3549 2 1 0 1 17
3W1K_J 0.80 0.68 0.93 26 4158 3 1 1 1 12
3W3S_B 0.78 0.65 0.93 26 4725 4 0 2 2 14
3ZEX_D 0.82 0.73 0.92 36 6982 3 0 3 0 13
3ZEX_C 0.53 0.37 0.76 19 14171 10 1 5 4 33
3ZND_W 0.47 0.43 0.53 10 2984 12 0 9 3 13
4A1C_3 0.83 0.70 0.97 38 7101 1 0 1 0 16
4A1C_2 0.57 0.45 0.71 15 11760 12 0 6 6 18
4AOB_A 0.72 0.57 0.92 24 4345 3 0 2 1 18
4ENB_A 0.50 0.42 0.62 8 1262 5 1 4 0 11
4ENC_A 0.50 0.42 0.62 8 1313 5 1 4 0 11
4FRG_B 0.74 0.63 0.87 20 3463 3 1 2 0 12
4FRN_A 0.73 0.61 0.88 22 5126 3 2 1 0 14
4JF2_A 0.72 0.52 1.00 16 2834 0 0 0 0 15

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Performance of MaxExpect - scored lower in this pairwise comparison

1. Total counts & total scores for MaxExpect

Total Base Pair Counts
Total TP 682
Total TN 1251632
Total FP 525
Total FP CONTRA 35
Total FP INCONS 436
Total FP COMP 54
Total FN 870
Total Scores
MCC 0.509
Average MCC ± 95% Confidence Intervals 0.497 ± 0.101
Sensitivity 0.439
Positive Predictive Value 0.592
Nr of predictions 26

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2. Individual counts for MaxExpect [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
3J16_L 0.29 0.23 0.37 7 2756 12 0 12 0 23
3J20_1 0.73 0.70 0.76 16 2905 5 0 5 0 7
3J20_2 0.49 0.44 0.56 276 1116272 221 10 207 4 357
3J20_0 0.44 0.40 0.50 12 2826 13 0 12 1 18
3J2L_3 0.62 0.53 0.74 28 7837 12 0 10 2 25
3J3D_C 0.47 0.43 0.52 12 2752 11 1 10 0 16
3J3E_8 0.07 0.06 0.08 2 7478 32 2 21 9 31
3J3E_7 0.46 0.37 0.59 20 7106 14 1 13 0 34
3J3F_8 0.32 0.31 0.33 11 12213 36 3 19 14 25
3J3F_7 0.79 0.68 0.92 34 7223 4 0 3 1 16
3J3V_B 0.50 0.40 0.62 23 6984 14 1 13 0 34
3UZL_B 0.77 0.62 0.96 23 3546 1 0 1 0 14
3W1K_J 0.87 0.79 0.97 30 4155 1 1 0 0 8
3W3S_B 0.88 0.78 1.00 31 4722 1 0 0 1 9
3ZEX_D 0.69 0.61 0.79 30 6983 8 1 7 0 19
3ZEX_C 0.41 0.27 0.64 14 14174 16 2 6 8 38
3ZND_W 0.20 0.22 0.19 5 2977 23 1 20 2 18
4A1C_3 0.69 0.57 0.84 31 7103 6 0 6 0 23
4A1C_2 0.14 0.15 0.14 5 11746 41 4 26 11 28
4AOB_A 0.50 0.40 0.63 17 4344 11 2 8 1 25
4ENB_A 0.76 0.58 1.00 11 1264 0 0 0 0 8
4ENC_A 0.31 0.26 0.38 5 1313 8 1 7 0 14
4FRG_B 0.30 0.22 0.41 7 3469 10 1 9 0 25
4FRN_A 0.45 0.36 0.57 13 5128 10 2 8 0 23
4JF2_A 0.78 0.61 1.00 19 2831 0 0 0 0 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.