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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of Murlet(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & Murlet(20) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) Murlet(20)
MCC 0.719 > 0.564
Average MCC ± 95% Confidence Intervals 0.696 ± 0.078 > 0.540 ± 0.100
Sensitivity 0.597 > 0.418
Positive Predictive Value 0.870 > 0.765
Total TP 410 > 287
Total TN 110724 < 110820
Total FP 88 < 109
Total FP CONTRA 4 < 5
Total FP INCONS 57 < 83
Total FP COMP 27 > 21
Total FN 277 < 400
P-value 2.71568867205e-08

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and Murlet(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Murlet(20)).

  2. Comparison of performance of PETfold_pre2.0(seed) and Murlet(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Murlet(20)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Murlet(20)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Murlet(20)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and Murlet(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Murlet(20)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and Murlet(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Murlet(20)).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 410
Total TN 110724
Total FP 88
Total FP CONTRA 4
Total FP INCONS 57
Total FP COMP 27
Total FN 277
Total Scores
MCC 0.719
Average MCC ± 95% Confidence Intervals 0.696 ± 0.078
Sensitivity 0.597
Positive Predictive Value 0.870
Nr of predictions 18

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 0.96 0.91 1.00 21 2905 1 0 0 1 2
3J20_0 0.84 0.70 1.00 21 2829 1 0 0 1 9
3J2L_3 0.77 0.62 0.94 33 7840 4 0 2 2 20
3J3D_C 0.82 0.71 0.95 20 2754 2 0 1 1 8
3J3E_8 0.43 0.30 0.63 10 7487 8 0 6 2 23
3J3E_7 0.78 0.67 0.92 36 7101 3 0 3 0 18
3J3F_8 0.63 0.53 0.76 19 12221 10 0 6 4 17
3J3F_7 0.85 0.74 0.97 37 7222 2 0 1 1 13
3J3V_B 0.76 0.61 0.95 35 6984 3 0 2 1 22
3ZEX_D 0.82 0.73 0.92 36 6982 3 0 3 0 13
3ZEX_C 0.53 0.37 0.76 19 14171 10 1 5 4 33
3ZND_W 0.47 0.43 0.53 10 2984 12 0 9 3 13
4A1C_2 0.57 0.45 0.71 15 11760 12 0 6 6 18
4A1C_3 0.83 0.70 0.97 38 7101 1 0 1 0 16
4AOB_A 0.72 0.57 0.92 24 4345 3 0 2 1 18
4ENB_A 0.50 0.42 0.62 8 1262 5 1 4 0 11
4ENC_A 0.50 0.42 0.62 8 1313 5 1 4 0 11
4FRG_B 0.74 0.63 0.87 20 3463 3 1 2 0 12

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Performance of Murlet(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 287
Total TN 110820
Total FP 109
Total FP CONTRA 5
Total FP INCONS 83
Total FP COMP 21
Total FN 400
Total Scores
MCC 0.564
Average MCC ± 95% Confidence Intervals 0.540 ± 0.100
Sensitivity 0.418
Positive Predictive Value 0.765
Nr of predictions 18

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 0.68 0.57 0.81 13 2910 3 0 3 0 10
3J20_0 0.58 0.47 0.74 14 2831 5 0 5 0 16
3J2L_3 0.69 0.49 0.96 26 7848 3 0 1 2 27
3J3D_C 0.78 0.64 0.95 18 2756 1 0 1 0 10
3J3E_8 0.24 0.15 0.38 5 7490 13 1 7 5 28
3J3E_7 0.77 0.63 0.94 34 7104 2 0 2 0 20
3J3F_8 0.48 0.36 0.65 13 12226 10 0 7 3 23
3J3F_7 0.69 0.50 0.96 25 7234 1 0 1 0 25
3J3V_B 0.63 0.40 1.00 23 6998 0 0 0 0 34
3ZEX_D 0.77 0.65 0.91 32 6986 3 0 3 0 17
3ZEX_C 0.34 0.23 0.50 12 14172 15 1 11 3 40
3ZND_W 0.45 0.39 0.53 9 2986 11 0 8 3 14
4A1C_2 0.17 0.15 0.20 5 11756 24 2 18 4 28
4A1C_3 0.59 0.41 0.85 22 7114 4 0 4 0 32
4AOB_A 0.72 0.55 0.96 23 4347 2 0 1 1 19
4ENB_A 0.46 0.21 1.00 4 1271 0 0 0 0 15
4ENC_A 0.51 0.26 1.00 5 1321 0 0 0 0 14
4FRG_B 0.17 0.13 0.25 4 3470 12 1 11 0 28

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.