CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Pknots - scored higher in this pairwise comparison

  4. Performance of Vsfold4 - scored lower in this pairwise comparison

  5. Compile and download dataset for Pknots & Vsfold4 [.zip] - may take several seconds...


Overview

Metric Pknots Vsfold4
MCC 0.625 > 0.581
Average MCC ± 95% Confidence Intervals 0.678 ± 0.053 > 0.633 ± 0.054
Sensitivity 0.564 > 0.493
Positive Predictive Value 0.698 > 0.692
Total TP 1636 > 1430
Total TN 314376 < 314655
Total FP 803 > 711
Total FP CONTRA 92 > 61
Total FP INCONS 616 > 574
Total FP COMP 95 > 76
Total FN 1263 < 1469
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of Pknots and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Pknots and Vsfold4).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Pknots and Vsfold4).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Pknots and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Pknots and Vsfold4).

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Performance of Pknots - scored higher in this pairwise comparison

1. Total counts & total scores for Pknots

Total Base Pair Counts
Total TP 1636
Total TN 314376
Total FP 803
Total FP CONTRA 92
Total FP INCONS 616
Total FP COMP 95
Total FN 1263
Total Scores
MCC 0.625
Average MCC ± 95% Confidence Intervals 0.678 ± 0.053
Sensitivity 0.564
Positive Predictive Value 0.698
Nr of predictions 125

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2. Individual counts for Pknots [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.90 0.82 1.00 9 397 0 0 0 0 2
2K63_A - 0.95 0.90 1.00 9 397 0 0 0 0 1
2K66_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KEZ_A - 0.89 0.80 1.00 8 268 0 0 0 0 2
2KFC_A - 0.11 0.10 0.17 2 618 10 0 10 0 18
2KGP_A - 0.81 0.67 1.00 6 294 1 0 0 1 3
2KMJ_A - 1.00 1.00 1.00 11 367 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.67 0.58 0.79 23 5122 9 2 4 3 17
2KU0_A - -0.02 0.00 0.00 0 693 10 0 10 0 16
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2KXM_A - -0.02 0.00 0.00 0 346 5 0 5 0 10
2KZL_A - 0.59 0.53 0.67 10 1470 5 1 4 0 9
2L1F_A 0.98 0.96 1.00 23 2057 0 0 0 0 1
2L1F_B 0.98 0.96 1.00 24 2121 0 0 0 0 1
2L2K_A - 0.94 0.89 1.00 17 844 0 0 0 0 2
2L3C_B - 0.87 0.76 1.00 13 548 0 0 0 0 4
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.94 0.88 1.00 30 2455 0 0 0 0 4
2L5Z_A - 0.86 0.75 1.00 9 316 0 0 0 0 3
2L94_A 0.92 0.90 0.95 18 971 1 0 1 0 2
2LA5_A - 0.46 0.26 0.83 5 624 1 0 1 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A 0.79 0.75 0.83 15 1522 3 1 2 0 5
2LDL_A - 0.90 0.82 1.00 9 342 1 0 0 1 2
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.44 0.44 0.45 17 6067 22 4 17 1 22
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LWK_A - 0.33 0.23 0.50 3 490 3 0 3 0 10
2RP0_A - 0.66 0.58 0.78 7 342 2 1 1 0 5
2RPT_A - 1.00 1.00 1.00 7 183 0 0 0 0 0
2RRC_A - 0.77 0.60 1.00 6 225 0 0 0 0 4
2WRQ_Y 0.57 0.59 0.56 10 2832 12 5 3 4 7
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WW9_D - 0.35 0.31 0.42 8 1934 11 2 9 0 18
2WW9_E - 0.39 0.29 0.57 4 554 3 0 3 0 10
2WWQ_V 0.24 0.21 0.29 6 2905 16 1 14 1 22
2XKV_B 0.23 0.25 0.22 5 4537 31 1 17 13 15
2XQD_Y 0.88 0.78 1.00 21 2829 0 0 0 0 6
2XXA_G 0.32 0.31 0.34 13 5113 25 1 24 0 29
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.59 0.50 0.71 12 2261 6 1 4 1 12
2YIE_Z - -0.01 0.00 0.00 0 1525 15 3 12 0 12
2YIE_X - 0.36 0.33 0.40 4 1368 6 2 4 0 8
2ZY6_A - 0.58 0.58 0.58 7 691 5 1 4 0 5
2ZZM_B 0.20 0.19 0.23 6 3460 20 2 18 0 26
2ZZN_D 0.86 0.78 0.95 21 2463 1 0 1 0 6
3A2K_C 0.45 0.43 0.48 12 2901 13 2 11 0 16
3A3A_A 0.87 0.76 1.00 28 3627 0 0 0 0 9
3ADB_C - 0.92 0.84 1.00 32 4154 0 0 0 0 6
3AKZ_H 0.84 0.75 0.95 21 2679 1 1 0 0 7
3AM1_B - 0.91 0.83 1.00 29 3211 0 0 0 0 6
3AMU_B 0.86 0.74 1.00 20 2983 2 0 0 2 7
3DW4_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
3G4S_9 0.25 0.21 0.31 12 7342 27 0 27 0 45
3GCA_A - 0.35 0.24 0.57 4 521 3 0 3 0 13
3GX2_A 0.47 0.40 0.55 16 4342 14 1 12 1 24
3HAY_E - 0.86 0.83 0.88 15 2261 5 0 2 3 3
3HJW_D - 0.94 0.89 1.00 16 1637 3 0 0 3 2
3IAB_R - 0.86 0.86 0.86 12 1021 4 1 1 2 2
3ID5_D - -0.01 0.00 0.00 0 491 5 1 4 0 9
3IVN_B 0.78 0.65 0.95 20 2325 1 0 1 0 11
3IWN_A 0.21 0.18 0.25 6 4254 18 1 17 0 27
3IZF_C 0.70 0.61 0.80 33 6862 8 1 7 0 21
3J0L_h - 0.58 0.49 0.70 21 6075 11 0 9 2 22
3J0L_2 - 0.36 0.36 0.36 12 6183 23 3 18 2 21
3J0L_g - -0.01 0.00 0.00 0 460 5 2 3 0 4
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_a - 0.35 0.31 0.42 5 1116 7 1 6 0 11
3J0L_1 - 0.65 0.47 0.90 9 1215 2 0 1 1 10
3J0L_7 - 0.28 0.29 0.29 5 1208 12 0 12 0 12
3J16_L 0.34 0.30 0.41 9 2753 13 0 13 0 21
3J20_0 0.84 0.70 1.00 21 2829 1 0 0 1 9
3J20_1 0.96 0.91 1.00 21 2905 0 0 0 0 2
3J2L_3 0.62 0.51 0.75 27 7839 12 0 9 3 26
3JYV_7 0.81 0.66 1.00 21 2829 0 0 0 0 11
3JYX_4 0.18 0.21 0.16 7 12203 41 13 23 5 26
3JYX_3 0.34 0.37 0.31 10 6296 24 9 13 2 17
3KTW_C - 0.49 0.44 0.56 19 4526 16 2 13 1 24
3LA5_A 0.80 0.65 1.00 22 2463 0 0 0 0 12
3NDB_M - 0.77 0.69 0.88 42 9132 7 1 5 1 19
3NKB_B - 0.55 0.50 0.62 13 1995 8 0 8 0 13
3NMU_E - 0.54 0.50 0.60 3 556 5 0 2 3 3
3NPB_A 0.76 0.67 0.86 31 6985 8 1 4 3 15
3O58_2 0.83 0.74 0.93 28 7230 3 0 2 1 10
3O58_3 0.27 0.31 0.24 11 12357 38 11 24 3 24
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.54 0.44 0.65 32 12831 19 0 17 2 40
3R4F_A - 0.92 0.88 0.96 22 2122 1 0 1 0 3
3R9X_C - 0.73 0.70 0.78 7 586 5 0 2 3 3
3RKF_A 0.77 0.62 0.95 21 2189 1 0 1 0 13
3SD1_A 0.65 0.52 0.81 22 3889 5 0 5 0 20
3SIU_F - 0.73 0.55 1.00 6 372 0 0 0 0 5
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.26 0.22 0.32 8 3135 17 0 17 0 29
3UZL_B 0.75 0.59 0.96 22 3547 1 0 1 0 15
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.71 0.63 0.81 25 4722 7 0 6 1 15
3ZEX_D 0.27 0.24 0.30 12 6981 28 0 28 0 37
3ZEX_G - 0.36 0.32 0.41 24 16413 37 3 31 3 50
4A1C_3 0.25 0.22 0.29 12 7099 29 1 28 0 42
4A1C_2 0.24 0.24 0.25 8 11749 36 3 21 12 25
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.17 0.14 0.21 6 4343 23 1 21 1 36
4ATO_G - 0.30 0.30 0.33 3 519 6 2 4 0 7
4ENB_A 0.83 0.79 0.88 15 1258 2 1 1 0 4
4ENC_A 0.86 0.79 0.94 15 1310 1 1 0 0 4
4FRG_B 0.48 0.38 0.63 12 3467 7 0 7 0 20
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0

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Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 1430
Total TN 314655
Total FP 711
Total FP CONTRA 61
Total FP INCONS 574
Total FP COMP 76
Total FN 1469
Total Scores
MCC 0.581
Average MCC ± 95% Confidence Intervals 0.633 ± 0.054
Sensitivity 0.493
Positive Predictive Value 0.692
Nr of predictions 125

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.37 0.36 0.40 4 396 6 0 6 0 7
2K63_A - 0.95 0.90 1.00 9 397 0 0 0 0 1
2K66_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KEZ_A - 0.70 0.50 1.00 5 271 0 0 0 0 5
2KFC_A - 0.49 0.25 1.00 5 625 0 0 0 0 15
2KGP_A - -0.02 0.00 0.00 0 296 4 0 4 0 9
2KMJ_A - 1.00 1.00 1.00 11 367 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.65 0.53 0.81 21 5125 7 0 5 2 19
2KU0_A - -0.02 0.00 0.00 0 694 9 0 9 0 16
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2KXM_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
2KZL_A - 0.86 0.74 1.00 14 1471 0 0 0 0 5
2L1F_A 0.66 0.54 0.81 13 2064 3 0 3 0 11
2L1F_B 0.68 0.56 0.82 14 2128 3 0 3 0 11
2L2K_A - 0.89 0.79 1.00 15 846 0 0 0 0 4
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.87 0.76 1.00 26 2459 0 0 0 0 8
2L5Z_A - 0.60 0.50 0.75 6 317 2 0 2 0 6
2L94_A 0.92 0.85 1.00 17 973 0 0 0 0 3
2LA5_A - 0.46 0.26 0.83 5 624 1 0 1 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A -0.01 0.00 0.00 0 1527 13 0 13 0 20
2LDL_A - 0.85 0.73 1.00 8 343 1 0 0 1 3
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.31 0.28 0.34 11 6073 21 3 18 0 28
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LWK_A - 0.83 0.77 0.91 10 485 1 0 1 0 3
2RP0_A - 0.64 0.42 1.00 5 346 0 0 0 0 7
2RPT_A - -0.03 0.00 0.00 0 186 4 0 4 0 7
2RRC_A - 0.70 0.50 1.00 5 226 0 0 0 0 5
2WRQ_Y 0.53 0.53 0.53 9 2833 12 5 3 4 8
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WW9_D - 0.19 0.12 0.33 3 1944 6 0 6 0 23
2WW9_E - -0.01 0.00 0.00 0 556 5 0 5 0 14
2WWQ_V 0.64 0.50 0.82 14 2909 4 0 3 1 14
2XKV_B -0.01 0.00 0.00 0 4533 27 8 19 0 20
2XQD_Y 0.86 0.74 1.00 20 2830 0 0 0 0 7
2XXA_G -0.01 0.00 0.00 0 5122 29 1 28 0 42
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.63 0.50 0.80 12 2263 4 0 3 1 12
2YIE_Z - -0.01 0.00 0.00 0 1529 11 3 8 0 12
2YIE_X - 0.36 0.33 0.40 4 1368 6 2 4 0 8
2ZY6_A - 0.58 0.58 0.58 7 691 5 1 4 0 5
2ZZM_B 0.21 0.19 0.24 6 3461 19 0 19 0 26
2ZZN_D 0.86 0.78 0.95 21 2463 1 0 1 0 6
3A2K_C 0.84 0.71 1.00 20 2906 0 0 0 0 8
3A3A_A 0.85 0.73 1.00 27 3628 0 0 0 0 10
3ADB_C - 0.89 0.79 1.00 30 4156 0 0 0 0 8
3AKZ_H 0.67 0.57 0.80 16 2681 5 1 3 1 12
3AM1_B - 0.84 0.71 1.00 25 3215 0 0 0 0 10
3AMU_B 0.64 0.56 0.75 15 2983 7 0 5 2 12
3DW4_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
3G4S_9 0.30 0.23 0.39 13 7348 20 1 19 0 44
3GCA_A - 0.54 0.29 1.00 5 523 0 0 0 0 12
3GX2_A 0.50 0.40 0.64 16 4346 10 0 9 1 24
3HAY_E - 0.91 0.83 1.00 15 2263 3 0 0 3 3
3HJW_D - 0.51 0.50 0.53 9 1636 8 0 8 0 9
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3ID5_D - 0.44 0.33 0.60 3 491 4 0 2 2 6
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IWN_A 0.27 0.21 0.35 7 4258 13 1 12 0 26
3IZF_C 0.69 0.56 0.86 30 6868 5 0 5 0 24
3J0L_h - 0.38 0.28 0.52 12 6082 11 0 11 0 31
3J0L_2 - 0.38 0.36 0.41 12 6187 18 3 14 1 21
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_8 - 0.70 0.50 1.00 4 186 0 0 0 0 4
3J0L_a - 0.39 0.31 0.50 5 1118 5 2 3 0 11
3J0L_1 - 0.28 0.21 0.40 4 1215 6 1 5 0 15
3J0L_7 - 0.51 0.41 0.64 7 1214 4 0 4 0 10
3J16_L 0.82 0.67 1.00 20 2755 0 0 0 0 10
3J20_0 0.84 0.70 1.00 21 2829 1 0 0 1 9
3J20_1 0.71 0.70 0.73 16 2904 6 0 6 0 7
3J2L_3 0.57 0.45 0.73 24 7842 12 1 8 3 29
3JYV_7 -0.01 0.00 0.00 0 2831 19 0 19 0 32
3JYX_4 0.10 0.09 0.12 3 12220 33 2 21 10 30
3JYX_3 0.60 0.56 0.65 15 6305 11 4 4 3 12
3KTW_C - 0.36 0.28 0.48 12 4535 13 3 10 0 31
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.28 0.23 0.35 14 9140 26 0 26 0 47
3NKB_B - 0.59 0.54 0.67 14 1995 7 0 7 0 12
3NMU_E - 0.41 0.17 1.00 1 560 3 0 0 3 5
3NPB_A 0.61 0.50 0.74 23 6990 9 0 8 1 23
3O58_2 0.47 0.42 0.53 16 7230 16 3 11 2 22
3O58_3 0.09 0.09 0.10 3 12373 35 5 22 8 32
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.57 0.44 0.74 32 12837 13 0 11 2 40
3R4F_A - 0.94 0.88 1.00 22 2123 0 0 0 0 3
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.19 0.17 0.24 7 3887 22 1 21 0 35
3SIU_F - 0.73 0.55 1.00 6 372 0 0 0 0 5
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.38 0.32 0.46 12 3134 14 0 14 0 25
3UZL_B 0.53 0.41 0.71 15 3549 6 1 5 0 22
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.67 0.58 0.79 23 4724 7 0 6 1 17
3ZEX_D 0.55 0.45 0.69 22 6989 10 0 10 0 27
3ZEX_G - 0.30 0.23 0.39 17 16427 27 2 25 0 57
4A1C_3 0.26 0.22 0.32 12 7103 25 2 23 0 42
4A1C_2 0.28 0.24 0.33 8 11757 28 0 16 12 25
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.42 0.33 0.54 14 4345 13 1 11 1 28
4ATO_G - 0.32 0.30 0.38 3 520 5 1 4 0 7
4ENB_A 0.76 0.58 1.00 11 1264 0 0 0 0 8
4ENC_A 0.69 0.47 1.00 9 1317 0 0 0 0 10
4FRG_B 0.56 0.47 0.68 15 3464 7 1 6 0 17
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.