CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASLOpt - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASLOpt & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric RNASLOpt Mastr(seed)
MCC 0.533 > 0.000
Average MCC ± 95% Confidence Intervals 0.551 ± 0.120 > 0.000 ± 0.000
Sensitivity 0.431 > 0.000
Positive Predictive Value 0.666 > 0.000
Total TP 245 > 0
Total TN 81668 < 82036
Total FP 146 > 0
Total FP CONTRA 17 > 0
Total FP INCONS 106 > 0
Total FP COMP 23 > 0
Total FN 324 < 569
P-value 2.48055519165e-08

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Performance plots


  1. Comparison of performance of RNASLOpt and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASLOpt and Mastr(seed)).

  2. Comparison of performance of RNASLOpt and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASLOpt and Mastr(seed)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASLOpt and Mastr(seed)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASLOpt and Mastr(seed)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASLOpt and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASLOpt and Mastr(seed)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASLOpt and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASLOpt and Mastr(seed)).

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Performance of RNASLOpt - scored higher in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP 245
Total TN 81668
Total FP 146
Total FP CONTRA 17
Total FP INCONS 106
Total FP COMP 23
Total FN 324
Total Scores
MCC 0.533
Average MCC ± 95% Confidence Intervals 0.551 ± 0.120
Sensitivity 0.431
Positive Predictive Value 0.666
Nr of predictions 16

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.47 0.35 0.64 7 1529 4 0 4 0 13
3J16_L 0.53 0.40 0.71 12 2758 5 0 5 0 18
3J20_1 0.96 0.91 1.00 21 2905 0 0 0 0 2
3J20_0 0.66 0.57 0.77 17 2828 6 1 4 1 13
3J2L_3 0.56 0.43 0.72 23 7843 11 0 9 2 30
3UZL_B 0.48 0.32 0.71 12 3553 5 0 5 0 25
3W3S_B 0.82 0.70 0.97 28 4724 2 0 1 1 12
3ZEX_C 0.26 0.21 0.33 11 14163 35 2 20 13 41
3ZEX_D 0.76 0.59 0.97 29 6991 1 0 1 0 20
4A1C_3 0.67 0.52 0.88 28 7108 4 0 4 0 26
4A1C_2 0.23 0.24 0.22 8 11744 35 8 21 6 25
4AOB_A 0.26 0.19 0.38 8 4350 13 2 11 0 34
4ENB_A 0.76 0.58 1.00 11 1264 0 0 0 0 8
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10
4FRG_B 0.56 0.47 0.68 15 3464 7 1 6 0 17
4FRN_A 0.20 0.17 0.26 6 5128 17 2 15 0 30

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 0
Total TN 82036
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 569
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 16

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.00 0.00 0.00 0 1540 0 0 0 0 20
3J16_L 0.00 0.00 0.00 0 2775 0 0 0 0 30
3J20_1 0.00 0.00 0.00 0 2926 0 0 0 0 23
3J20_0 0.00 0.00 0.00 0 2850 0 0 0 0 30
3J2L_3 0.00 0.00 0.00 0 7875 0 0 0 0 53
3UZL_B 0.00 0.00 0.00 0 3570 0 0 0 0 37
3W3S_B 0.00 0.00 0.00 0 4753 0 0 0 0 40
3ZEX_C 0.00 0.00 0.00 0 14196 0 0 0 0 52
3ZEX_D 0.00 0.00 0.00 0 7021 0 0 0 0 49
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32
4FRN_A 0.00 0.00 0.00 0 5151 0 0 0 0 36

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.