CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASampler(20) - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASampler(20) & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric RNASampler(20) Carnac(seed)
MCC 0.613 > 0.186
Average MCC ± 95% Confidence Intervals 0.621 ± 0.090 > 0.084 ± 0.120
Sensitivity 0.460 > 0.035
Positive Predictive Value 0.820 < 1.000
Total TP 382 > 29
Total TN 134586 < 135023
Total FP 133 > 0
Total FP CONTRA 10 > 0
Total FP INCONS 74 > 0
Total FP COMP 49 > 0
Total FN 448 < 801
P-value 4.89920829651e-08

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Performance plots


  1. Comparison of performance of RNASampler(20) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and Carnac(seed)).

  2. Comparison of performance of RNASampler(20) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and Carnac(seed)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and Carnac(seed)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and Carnac(seed)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and Carnac(seed)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and Carnac(seed)).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP 382
Total TN 134586
Total FP 133
Total FP CONTRA 10
Total FP INCONS 74
Total FP COMP 49
Total FN 448
Total Scores
MCC 0.613
Average MCC ± 95% Confidence Intervals 0.621 ± 0.090
Sensitivity 0.460
Positive Predictive Value 0.820
Nr of predictions 23

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2L94_A 0.92 0.90 0.95 18 971 1 0 1 0 2
2XKV_B 0.45 0.20 1.00 4 4556 2 0 0 2 16
2XXA_G 0.31 0.10 1.00 4 5147 0 0 0 0 38
3GX2_A 0.74 0.55 1.00 22 4349 1 0 0 1 18
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IZF_C 0.74 0.57 0.97 31 6871 1 0 1 0 23
3JYX_4 0.32 0.30 0.34 10 12217 26 4 15 7 23
3JYX_3 0.58 0.44 0.75 12 6312 11 0 4 7 15
3LA5_A 0.76 0.59 1.00 20 2465 0 0 0 0 14
3NPB_A 0.68 0.48 0.96 22 6998 4 1 0 3 24
3O58_3 0.43 0.34 0.55 12 12381 18 2 8 8 23
3O58_2 0.79 0.71 0.87 27 7229 5 2 2 1 11
3PDR_A 0.70 0.53 0.93 38 12839 5 0 3 2 34
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.67 0.48 0.95 20 3895 1 0 1 0 22
3ZEX_C 0.27 0.19 0.38 10 14170 20 1 15 4 42
4A1C_3 0.74 0.56 1.00 30 7110 0 0 0 0 24
4A1C_2 0.18 0.15 0.23 5 11759 30 0 17 13 28
4AOB_A 0.58 0.40 0.85 17 4351 4 0 3 1 25
4ENB_A 0.60 0.37 1.00 7 1268 0 0 0 0 12
4ENC_A 0.76 0.58 1.00 11 1315 0 0 0 0 8
4FRG_B 0.55 0.41 0.76 13 3469 4 0 4 0 19

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 29
Total TN 135023
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 801
Total Scores
MCC 0.186
Average MCC ± 95% Confidence Intervals 0.084 ± 0.120
Sensitivity 0.035
Positive Predictive Value 1.000
Nr of predictions 23

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2XKV_B 0.00 0.00 0.00 0 4560 0 0 0 0 20
2XXA_G 0.00 0.00 0.00 0 5151 0 0 0 0 42
3GX2_A 0.00 0.00 0.00 0 4371 0 0 0 0 40
3IVN_B 0.00 0.00 0.00 0 2346 0 0 0 0 31
3IZF_C 0.00 0.00 0.00 0 6903 0 0 0 0 54
3JYX_4 0.00 0.00 0.00 0 12246 0 0 0 0 33
3JYX_3 0.00 0.00 0.00 0 6328 0 0 0 0 27
3LA5_A 0.00 0.00 0.00 0 2485 0 0 0 0 34
3NPB_A 0.00 0.00 0.00 0 7021 0 0 0 0 46
3O58_3 0.00 0.00 0.00 0 12403 0 0 0 0 35
3O58_2 0.00 0.00 0.00 0 7260 0 0 0 0 38
3PDR_A 0.00 0.00 0.00 0 12880 0 0 0 0 72
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
3ZEX_C 0.00 0.00 0.00 0 14196 0 0 0 0 52
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.