CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASampler(20) - scored higher in this pairwise comparison

  4. Performance of Fold - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASampler(20) & Fold [.zip] - may take several seconds...


Overview

Metric RNASampler(20) Fold
MCC 0.613 > 0.589
Average MCC ± 95% Confidence Intervals 0.633 ± 0.087 > 0.590 ± 0.103
Sensitivity 0.455 < 0.525
Positive Predictive Value 0.830 > 0.664
Total TP 453 < 522
Total TN 203725 > 203485
Total FP 136 < 330
Total FP CONTRA 13 < 32
Total FP INCONS 80 < 232
Total FP COMP 43 < 66
Total FN 542 > 473
P-value 5.1503931209e-08

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Performance plots


  1. Comparison of performance of RNASampler(20) and Fold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and Fold).

  2. Comparison of performance of RNASampler(20) and Fold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and Fold).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and Fold).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and Fold).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and Fold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and Fold).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and Fold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and Fold).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP 453
Total TN 203725
Total FP 136
Total FP CONTRA 13
Total FP INCONS 80
Total FP COMP 43
Total FN 542
Total Scores
MCC 0.613
Average MCC ± 95% Confidence Intervals 0.633 ± 0.087
Sensitivity 0.455
Positive Predictive Value 0.830
Nr of predictions 24

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.92 0.90 0.95 18 971 1 0 1 0 2
2XKV_B 0.45 0.20 1.00 4 4556 2 0 0 2 16
2XQD_Y 0.88 0.78 1.00 21 2829 0 0 0 0 6
2XXA_G 0.31 0.10 1.00 4 5147 0 0 0 0 38
3AMU_B 0.82 0.70 0.95 19 2983 3 0 1 2 8
3IZ4_A 0.47 0.32 0.69 42 70815 23 6 13 4 90
3IZF_C 0.74 0.57 0.97 31 6871 1 0 1 0 23
3J20_0 0.80 0.67 0.95 20 2829 2 0 1 1 10
3J20_1 0.96 0.91 1.00 21 2905 0 0 0 0 2
3J2L_3 0.45 0.32 0.63 17 7848 12 1 9 2 36
3NPB_A 0.68 0.48 0.96 22 6998 4 1 0 3 24
3O58_3 0.43 0.34 0.55 12 12381 18 2 8 8 23
3O58_2 0.79 0.71 0.87 27 7229 5 2 2 1 11
3PDR_A 0.70 0.53 0.93 38 12839 5 0 3 2 34
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.67 0.48 0.95 20 3895 1 0 1 0 22
3ZEX_C 0.27 0.19 0.38 10 14170 20 1 15 4 42
3ZEX_D 0.68 0.49 0.96 24 6996 1 0 1 0 25
4A1C_3 0.74 0.56 1.00 30 7110 0 0 0 0 24
4A1C_2 0.18 0.15 0.23 5 11759 30 0 17 13 28
4AOB_A 0.58 0.40 0.85 17 4351 4 0 3 1 25
4ENB_A 0.60 0.37 1.00 7 1268 0 0 0 0 12
4ENC_A 0.76 0.58 1.00 11 1315 0 0 0 0 8
4FRG_B 0.55 0.41 0.76 13 3469 4 0 4 0 19

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Performance of Fold - scored lower in this pairwise comparison

1. Total counts & total scores for Fold

Total Base Pair Counts
Total TP 522
Total TN 203485
Total FP 330
Total FP CONTRA 32
Total FP INCONS 232
Total FP COMP 66
Total FN 473
Total Scores
MCC 0.589
Average MCC ± 95% Confidence Intervals 0.590 ± 0.103
Sensitivity 0.525
Positive Predictive Value 0.664
Nr of predictions 24

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2. Individual counts for Fold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2XKV_B 0.51 0.50 0.53 10 4541 24 0 9 15 10
2XQD_Y 0.88 0.78 1.00 21 2829 0 0 0 0 6
2XXA_G 0.93 0.86 1.00 36 5115 0 0 0 0 6
3AMU_B 0.64 0.59 0.70 16 2980 9 0 7 2 11
3IZ4_A 0.53 0.46 0.61 61 70776 44 5 34 5 71
3IZF_C 0.70 0.59 0.82 32 6864 7 1 6 0 22
3J20_0 0.45 0.40 0.52 12 2827 12 0 11 1 18
3J20_1 0.96 0.91 1.00 21 2905 0 0 0 0 2
3J2L_3 0.62 0.53 0.74 28 7837 12 0 10 2 25
3NPB_A 0.70 0.61 0.80 28 6986 10 1 6 3 18
3O58_3 0.29 0.31 0.28 11 12363 41 3 26 12 24
3O58_2 0.71 0.71 0.71 27 7222 12 3 8 1 11
3PDR_A 0.77 0.64 0.94 46 12831 5 0 3 2 26
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.57 0.48 0.69 20 3887 9 1 8 0 22
3ZEX_C 0.22 0.21 0.24 11 14151 45 4 30 11 41
3ZEX_D 0.76 0.67 0.87 33 6983 5 1 4 0 16
4A1C_3 0.68 0.57 0.82 31 7102 7 1 6 0 23
4A1C_2 0.14 0.15 0.14 5 11744 43 5 27 11 28
4AOB_A 0.50 0.40 0.63 17 4344 11 2 8 1 25
4ENB_A 0.32 0.26 0.42 5 1263 7 1 6 0 14
4ENC_A 0.31 0.26 0.38 5 1313 8 1 7 0 14
4FRG_B 0.24 0.22 0.27 7 3460 19 3 16 0 25

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.