CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASampler(seed) - scored higher in this pairwise comparison

  4. Performance of RDfolder - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASampler(seed) & RDfolder [.zip] - may take several seconds...


Overview

Metric RNASampler(seed) RDfolder
MCC 0.734 > 0.632
Average MCC ± 95% Confidence Intervals 0.742 ± 0.132 > 0.657 ± 0.194
Sensitivity 0.572 > 0.518
Positive Predictive Value 0.949 > 0.779
Total TP 222 > 201
Total TN 29448 > 29424
Total FP 15 < 59
Total FP CONTRA 0 < 5
Total FP INCONS 12 < 52
Total FP COMP 3 > 2
Total FN 166 < 187
P-value 1.93248927742e-08

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Performance plots


  1. Comparison of performance of RNASampler(seed) and RDfolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(seed) and RDfolder).

  2. Comparison of performance of RNASampler(seed) and RDfolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(seed) and RDfolder).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(seed) and RDfolder).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(seed) and RDfolder).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(seed) and RDfolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(seed) and RDfolder).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(seed) and RDfolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(seed) and RDfolder).

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Performance of RNASampler(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(seed)

Total Base Pair Counts
Total TP 222
Total TN 29448
Total FP 15
Total FP CONTRA 0
Total FP INCONS 12
Total FP COMP 3
Total FN 166
Total Scores
MCC 0.734
Average MCC ± 95% Confidence Intervals 0.742 ± 0.132
Sensitivity 0.572
Positive Predictive Value 0.949
Nr of predictions 15

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2. Individual counts for RNASampler(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.92 0.84 1.00 16 1112 1 0 0 1 3
2KUR_A 0.90 0.81 1.00 17 1111 0 0 0 0 4
2KUU_A 0.87 0.76 1.00 16 1112 1 0 0 1 5
2KUV_A 0.88 0.77 1.00 17 1111 0 0 0 0 5
2KUW_A 0.90 0.81 1.00 17 1111 0 0 0 0 4
2L1F_B 0.82 0.68 1.00 17 2128 0 0 0 0 8
2L1F_A 0.81 0.67 1.00 16 2064 0 0 0 0 8
2L94_A 0.71 0.55 0.92 11 978 1 0 1 0 9
2LC8_A -0.01 0.00 0.00 0 1530 10 0 10 0 20
3A3A_A 0.70 0.49 1.00 18 3637 0 0 0 0 19
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.60 0.38 0.94 16 3899 1 0 1 0 26
3W3S_B 0.55 0.30 1.00 12 4741 1 0 0 1 28

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Performance of RDfolder - scored lower in this pairwise comparison

1. Total counts & total scores for RDfolder

Total Base Pair Counts
Total TP 201
Total TN 29424
Total FP 59
Total FP CONTRA 5
Total FP INCONS 52
Total FP COMP 2
Total FN 187
Total Scores
MCC 0.632
Average MCC ± 95% Confidence Intervals 0.657 ± 0.194
Sensitivity 0.518
Positive Predictive Value 0.779
Nr of predictions 15

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2. Individual counts for RDfolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.89 0.79 1.00 15 1113 1 0 0 1 4
2KUR_A 0.87 0.76 1.00 16 1112 0 0 0 0 5
2KUU_A 0.84 0.71 1.00 15 1113 1 0 0 1 6
2KUV_A 0.85 0.73 1.00 16 1112 0 0 0 0 6
2KUW_A 0.87 0.76 1.00 16 1112 0 0 0 0 5
2L1F_B 0.98 0.96 1.00 24 2121 0 0 0 0 1
2L1F_A -0.01 0.00 0.00 0 2067 13 2 11 0 24
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LC8_A -0.01 0.00 0.00 0 1526 14 2 12 0 20
3A3A_A 0.53 0.41 0.71 15 3634 6 0 6 0 22
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.30 0.17 0.54 7 3903 6 0 6 0 35
3W3S_B 0.27 0.23 0.33 9 4726 18 1 17 0 31

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.