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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAalifold(20) - scored higher in this pairwise comparison

  4. Performance of Murlet(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAalifold(20) & Murlet(seed) [.zip] - may take several seconds...


Overview

Metric RNAalifold(20) Murlet(seed)
MCC 0.586 > 0.463
Average MCC ± 95% Confidence Intervals 0.571 ± 0.084 > 0.469 ± 0.058
Sensitivity 0.428 > 0.250
Positive Predictive Value 0.807 < 0.863
Total TP 281 > 164
Total TN 107073 < 107231
Total FP 85 > 32
Total FP CONTRA 8 > 5
Total FP INCONS 59 > 21
Total FP COMP 18 > 6
Total FN 376 < 493
P-value 3.69956606048e-08

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Performance plots


  1. Comparison of performance of RNAalifold(20) and Murlet(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(20) and Murlet(seed)).

  2. Comparison of performance of RNAalifold(20) and Murlet(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(20) and Murlet(seed)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(20) and Murlet(seed)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(20) and Murlet(seed)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(20) and Murlet(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(20) and Murlet(seed)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(20) and Murlet(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(20) and Murlet(seed)).

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Performance of RNAalifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(20)

Total Base Pair Counts
Total TP 281
Total TN 107073
Total FP 85
Total FP CONTRA 8
Total FP INCONS 59
Total FP COMP 18
Total FN 376
Total Scores
MCC 0.586
Average MCC ± 95% Confidence Intervals 0.571 ± 0.084
Sensitivity 0.428
Positive Predictive Value 0.807
Nr of predictions 19

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2. Individual counts for RNAalifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.60 0.36 1.00 4 402 0 0 0 0 7
2L94_A 0.53 0.50 0.59 10 973 7 0 7 0 10
2XKV_B 0.45 0.20 1.00 4 4556 3 0 0 3 16
2XXA_G 0.41 0.17 1.00 7 5144 0 0 0 0 35
3GX2_A 0.77 0.60 1.00 24 4347 1 0 0 1 16
3IVN_B 0.74 0.58 0.95 18 2327 1 1 0 0 13
3JYX_4 0.39 0.30 0.50 10 12226 15 0 10 5 23
3LA5_A 0.75 0.56 1.00 19 2466 0 0 0 0 15
3NPB_A 0.68 0.48 0.96 22 6998 3 1 0 2 24
3O58_3 0.37 0.26 0.53 9 12386 8 2 6 0 26
3PDR_A 0.76 0.61 0.96 44 12834 3 0 2 1 28
3RKF_A 0.68 0.50 0.94 17 2193 1 0 1 0 17
3SD1_A 0.70 0.60 0.83 25 3886 5 1 4 0 17
3ZEX_C 0.39 0.27 0.56 14 14171 14 1 10 3 38
4A1C_2 0.17 0.15 0.19 5 11755 23 2 19 2 28
4AOB_A 0.72 0.52 1.00 22 4349 1 0 0 1 20
4ENB_A 0.46 0.21 1.00 4 1271 0 0 0 0 15
4ENC_A 0.56 0.32 1.00 6 1320 0 0 0 0 13
4FRG_B 0.73 0.53 1.00 17 3469 0 0 0 0 15

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Performance of Murlet(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 164
Total TN 107231
Total FP 32
Total FP CONTRA 5
Total FP INCONS 21
Total FP COMP 6
Total FN 493
Total Scores
MCC 0.463
Average MCC ± 95% Confidence Intervals 0.469 ± 0.058
Sensitivity 0.250
Positive Predictive Value 0.863
Nr of predictions 19

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.52 0.27 1.00 3 403 0 0 0 0 8
2L94_A 0.59 0.40 0.89 8 981 1 0 1 0 12
2XKV_B 0.45 0.20 1.00 4 4556 2 0 0 2 16
2XXA_G 0.38 0.14 1.00 6 5145 0 0 0 0 36
3GX2_A 0.59 0.35 1.00 14 4357 1 0 0 1 26
3IVN_B 0.53 0.39 0.75 12 2330 4 2 2 0 19
3JYX_4 0.23 0.09 0.60 3 12241 4 0 2 2 30
3LA5_A 0.58 0.41 0.82 14 2468 3 1 2 0 20
3NPB_A 0.49 0.28 0.87 13 7006 2 1 1 0 33
3O58_3 0.45 0.20 1.00 7 12396 0 0 0 0 28
3PDR_A 0.44 0.19 1.00 14 12866 0 0 0 0 58
3RKF_A 0.53 0.35 0.80 12 2196 3 1 2 0 22
3SD1_A 0.47 0.26 0.85 11 3903 2 0 2 0 31
3ZEX_C 0.37 0.13 1.00 7 14189 0 0 0 0 45
4A1C_2 0.46 0.21 1.00 7 11774 0 0 0 0 26
4AOB_A 0.58 0.33 1.00 14 4357 1 0 0 1 28
4ENB_A 0.56 0.32 1.00 6 1269 0 0 0 0 13
4ENC_A 0.56 0.32 1.00 6 1320 0 0 0 0 13
4FRG_B 0.15 0.09 0.25 3 3474 9 0 9 0 29

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.