CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAfold - scored higher in this pairwise comparison

  4. Performance of Vsfold5 - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAfold & Vsfold5 [.zip] - may take several seconds...


Overview

Metric RNAfold Vsfold5
MCC 0.630 > 0.510
Average MCC ± 95% Confidence Intervals 0.691 ± 0.051 > 0.601 ± 0.058
Sensitivity 0.565 > 0.441
Positive Predictive Value 0.707 > 0.596
Total TP 1815 > 1415
Total TN 466000 < 466193
Total FP 886 < 1045
Total FP CONTRA 93 < 110
Total FP INCONS 659 < 849
Total FP COMP 134 > 86
Total FN 1395 < 1795
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of RNAfold and Vsfold5. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAfold and Vsfold5).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAfold and Vsfold5).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAfold and Vsfold5. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAfold and Vsfold5).

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Performance of RNAfold - scored higher in this pairwise comparison

1. Total counts & total scores for RNAfold

Total Base Pair Counts
Total TP 1815
Total TN 466000
Total FP 886
Total FP CONTRA 93
Total FP INCONS 659
Total FP COMP 134
Total FN 1395
Total Scores
MCC 0.630
Average MCC ± 95% Confidence Intervals 0.691 ± 0.051
Sensitivity 0.565
Positive Predictive Value 0.707
Nr of predictions 127

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2. Individual counts for RNAfold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 395 0 0 0 0 0
2K63_A - 0.95 0.90 1.00 9 397 0 0 0 0 1
2K66_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KEZ_A - 0.89 0.80 1.00 8 268 0 0 0 0 2
2KFC_A - -0.02 0.00 0.00 0 623 7 0 7 0 20
2KGP_A - 1.00 1.00 1.00 9 291 1 0 0 1 0
2KMJ_A - 1.00 1.00 1.00 11 367 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.76 0.60 0.96 24 5126 5 0 1 4 16
2KU0_A - 0.86 0.75 1.00 12 691 0 0 0 0 4
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2KXM_A - 0.89 0.80 1.00 8 343 0 0 0 0 2
2KZL_A - 0.86 0.74 1.00 14 1471 0 0 0 0 5
2L1F_A 0.98 0.96 1.00 23 2057 0 0 0 0 1
2L1F_B 0.98 0.96 1.00 24 2121 0 0 0 0 1
2L2K_A - 0.94 0.89 1.00 17 844 0 0 0 0 2
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.94 0.88 1.00 30 2455 0 0 0 0 4
2L5Z_A - 0.86 0.75 1.00 9 316 0 0 0 0 3
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LA5_A - 0.39 0.26 0.63 5 622 3 1 2 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A 0.61 0.55 0.69 11 1524 5 0 5 0 9
2LDL_A - 0.90 0.82 1.00 9 342 1 0 0 1 2
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.93 0.87 1.00 34 6071 3 0 0 3 5
2LWK_A - 0.83 0.77 0.91 10 485 1 0 1 0 3
2RP0_A - 0.64 0.42 1.00 5 346 0 0 0 0 7
2RPT_A - 1.00 1.00 1.00 7 183 0 0 0 0 0
2RRC_A - 0.83 0.70 1.00 7 224 0 0 0 0 3
2WRQ_Y 0.57 0.59 0.56 10 2832 13 5 3 5 7
2WW9_E - 0.53 0.29 1.00 4 557 0 0 0 0 10
2WW9_D - 0.14 0.12 0.19 3 1937 13 0 13 0 23
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WWQ_V 0.76 0.68 0.86 19 2904 5 0 3 2 9
2XKV_B 0.51 0.50 0.53 10 4541 23 0 9 14 10
2XQD_Y 0.88 0.78 1.00 21 2829 0 0 0 0 6
2XXA_G 0.34 0.31 0.39 13 5118 20 1 19 0 29
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.65 0.63 0.68 15 2256 8 1 6 1 9
2YIE_X - 0.25 0.25 0.27 3 1367 11 1 7 3 9
2YIE_Z - -0.01 0.00 0.00 0 1525 15 3 12 0 12
2ZY6_A - 0.58 0.58 0.58 7 691 5 1 4 0 5
2ZZM_B 0.21 0.19 0.25 6 3462 18 0 18 0 26
2ZZN_D 0.82 0.78 0.88 21 2461 3 0 3 0 6
3A2K_C 0.42 0.39 0.46 11 2902 13 2 11 0 17
3A3A_A 0.87 0.76 1.00 28 3627 0 0 0 0 9
3ADB_C - 0.33 0.32 0.35 12 4152 22 0 22 0 26
3AKZ_H 0.43 0.39 0.48 11 2678 12 2 10 0 17
3AM1_B - 0.68 0.63 0.73 22 3210 8 1 7 0 13
3AMU_B 0.70 0.59 0.84 16 2984 5 0 3 2 11
3DW4_A - -0.02 0.00 0.00 0 345 6 0 6 0 10
3G4S_9 0.51 0.39 0.69 22 7349 10 1 9 0 35
3GCA_A - 0.54 0.29 1.00 5 523 0 0 0 0 12
3GX2_A 0.68 0.55 0.85 22 4345 5 0 4 1 18
3HAY_E - 0.91 0.83 1.00 15 2263 6 0 0 6 3
3HJW_D - 0.94 0.89 1.00 16 1637 2 0 0 2 2
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3ID5_D - 0.44 0.33 0.60 3 491 5 0 2 3 6
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IWN_A 0.63 0.58 0.70 19 4251 9 0 8 1 14
3IYQ_A 0.31 0.34 0.29 32 60616 80 24 54 2 62
3IZ4_A 0.51 0.47 0.55 62 70763 52 10 41 1 70
3IZF_C 0.59 0.52 0.67 28 6861 14 1 13 0 26
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_1 - 0.76 0.63 0.92 12 1212 2 0 1 1 7
3J0L_h - 0.75 0.60 0.93 26 6077 4 0 2 2 17
3J0L_2 - 0.25 0.24 0.26 8 6185 25 2 21 2 25
3J0L_7 - -0.01 0.00 0.00 0 1213 12 0 12 0 17
3J0L_g - -0.01 0.00 0.00 0 460 5 1 4 0 4
3J0L_a - 0.23 0.19 0.30 3 1118 7 1 6 0 13
3J16_L 0.75 0.57 1.00 17 2758 0 0 0 0 13
3J20_0 0.43 0.40 0.48 12 2825 14 0 13 1 18
3J20_1 0.96 0.91 1.00 21 2905 2 0 0 2 2
3J2C_O - 0.64 0.54 0.76 34 10251 12 0 11 1 29
3J2L_3 0.62 0.53 0.74 28 7837 12 0 10 2 25
3JYV_7 -0.01 0.00 0.00 0 2828 22 1 21 0 32
3JYX_4 0.31 0.30 0.32 10 12215 33 5 16 12 23
3JYX_3 0.62 0.63 0.61 17 6300 22 1 10 11 10
3KTW_C - 0.73 0.63 0.84 27 4528 6 2 3 1 16
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.77 0.69 0.86 42 9131 8 0 7 1 19
3NKB_B - 0.59 0.54 0.67 14 1995 7 0 7 0 12
3NMU_E - 0.54 0.50 0.60 3 556 5 0 2 3 3
3NPB_A 0.83 0.72 0.97 33 6987 4 0 1 3 13
3O58_3 0.34 0.34 0.34 12 12368 34 2 21 11 23
3O58_2 0.59 0.61 0.58 23 7220 19 4 13 2 15
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.75 0.63 0.90 45 12830 7 1 4 2 27
3R4F_A - 0.96 0.92 1.00 23 2122 0 0 0 0 2
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.64 0.52 0.79 22 3888 6 1 5 0 20
3SIU_F - 0.85 0.73 1.00 8 370 0 0 0 0 3
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.38 0.32 0.46 12 3134 14 0 14 0 25
3UZL_B 0.48 0.38 0.61 14 3547 9 0 9 0 23
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.55 0.50 0.61 20 4720 14 1 12 1 20
3ZEX_D 0.77 0.65 0.91 32 6986 3 0 3 0 17
3ZEX_E - 0.00 0.00 0.00 0 21893 54 4 48 2 77
4A1C_3 0.70 0.59 0.82 32 7101 7 1 6 0 22
4A1C_2 0.14 0.15 0.14 5 11744 43 5 27 11 28
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.50 0.40 0.63 17 4344 11 2 8 1 25
4ATO_G - 0.32 0.30 0.38 3 520 5 1 4 0 7
4ENB_A 0.70 0.58 0.85 11 1262 2 1 1 0 8
4ENC_A 0.32 0.26 0.42 5 1314 7 1 6 0 14
4FRG_B 0.32 0.28 0.38 9 3462 15 0 15 0 23
4FRN_A 0.52 0.44 0.62 16 5125 10 2 8 0 20

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Performance of Vsfold5 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP 1415
Total TN 466193
Total FP 1045
Total FP CONTRA 110
Total FP INCONS 849
Total FP COMP 86
Total FN 1795
Total Scores
MCC 0.510
Average MCC ± 95% Confidence Intervals 0.601 ± 0.058
Sensitivity 0.441
Positive Predictive Value 0.596
Nr of predictions 127

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 395 0 0 0 0 0
2K63_A - 0.95 0.90 1.00 9 397 0 0 0 0 1
2K66_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KDQ_B 0.90 0.82 1.00 9 397 0 0 0 0 2
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KEZ_A - 0.70 0.50 1.00 5 271 0 0 0 0 5
2KFC_A - 0.48 0.35 0.70 7 620 3 0 3 0 13
2KGP_A - 0.81 0.67 1.00 6 294 1 0 0 1 3
2KMJ_A - 0.95 0.91 1.00 10 368 0 0 0 0 1
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.57 0.50 0.65 20 5120 11 5 6 0 20
2KU0_A - -0.02 0.00 0.00 0 692 11 0 11 0 16
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KX8_A 0.91 0.83 1.00 15 846 0 0 0 0 3
2KXM_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
2KZL_A - 0.86 0.74 1.00 14 1471 0 0 0 0 5
2L1F_A 0.69 0.58 0.82 14 2063 3 0 3 0 10
2L1F_B 0.70 0.60 0.83 15 2127 3 0 3 0 10
2L2K_A - 0.89 0.79 1.00 15 846 0 0 0 0 4
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.87 0.76 1.00 26 2459 0 0 0 0 8
2L5Z_A - 0.60 0.50 0.75 6 317 2 0 2 0 6
2L94_A 0.95 0.90 1.00 18 972 0 0 0 0 2
2LA5_A - -0.02 0.00 0.00 0 623 7 0 7 0 19
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A -0.01 0.00 0.00 0 1527 13 0 13 0 20
2LDL_A - 0.85 0.73 1.00 8 343 1 0 0 1 3
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.89 0.80 1.00 8 268 0 0 0 0 2
2LKR_A - 0.27 0.23 0.32 9 6077 19 2 17 0 30
2LWK_A - 0.83 0.77 0.91 10 485 1 0 1 0 3
2RP0_A - 0.64 0.42 1.00 5 346 0 0 0 0 7
2RPT_A - 0.70 0.71 0.71 5 183 2 0 2 0 2
2RRC_A - 0.70 0.50 1.00 5 226 0 0 0 0 5
2WRQ_Y 0.53 0.53 0.53 9 2833 12 5 3 4 8
2WW9_E - -0.01 0.00 0.00 0 556 5 0 5 0 14
2WW9_D - 0.15 0.12 0.21 3 1939 11 1 10 0 23
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WWQ_V 0.64 0.50 0.82 14 2909 4 0 3 1 14
2XKV_B -0.01 0.00 0.00 0 4528 32 12 20 0 20
2XQD_Y 0.86 0.74 1.00 20 2830 0 0 0 0 7
2XXA_G -0.01 0.00 0.00 0 5120 31 2 29 0 42
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.61 0.54 0.68 13 2259 7 1 5 1 11
2YIE_X - 0.30 0.33 0.29 4 1364 10 2 8 0 8
2YIE_Z - -0.01 0.00 0.00 0 1529 11 3 8 0 12
2ZY6_A - 0.58 0.58 0.58 7 691 5 1 4 0 5
2ZZM_B 0.19 0.19 0.21 6 3458 22 1 21 0 26
2ZZN_D 0.86 0.78 0.95 21 2463 1 0 1 0 6
3A2K_C 0.84 0.71 1.00 20 2906 0 0 0 0 8
3A3A_A 0.85 0.73 1.00 27 3628 0 0 0 0 10
3ADB_C - 0.67 0.53 0.87 20 4163 3 0 3 0 18
3AKZ_H 0.84 0.71 1.00 20 2681 0 0 0 0 8
3AM1_B - 0.78 0.71 0.86 25 3211 4 1 3 0 10
3AMU_B 0.67 0.59 0.76 16 2982 7 0 5 2 11
3DW4_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
3G4S_9 0.08 0.07 0.11 4 7344 33 0 33 0 53
3GCA_A - 0.54 0.29 1.00 5 523 0 0 0 0 12
3GX2_A 0.51 0.40 0.67 16 4347 9 0 8 1 24
3HAY_E - 0.91 0.83 1.00 15 2263 3 0 0 3 3
3HJW_D - 0.48 0.50 0.47 9 1634 10 0 10 0 9
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3ID5_D - 0.44 0.33 0.60 3 491 4 0 2 2 6
3IVN_B 0.76 0.58 1.00 18 2328 0 0 0 0 13
3IWN_A 0.25 0.21 0.30 7 4255 16 1 15 0 26
3IYQ_A 0.33 0.31 0.35 29 60642 61 15 40 6 65
3IZ4_A 0.29 0.24 0.36 32 70787 62 8 49 5 100
3IZF_C 0.70 0.56 0.88 30 6869 4 0 4 0 24
3J0L_8 - 0.70 0.50 1.00 4 186 0 0 0 0 4
3J0L_1 - 0.27 0.21 0.36 4 1214 7 1 6 0 15
3J0L_h - 0.18 0.14 0.24 6 6080 19 1 18 0 37
3J0L_2 - 0.35 0.33 0.37 11 6186 21 3 16 2 22
3J0L_7 - -0.01 0.00 0.00 0 1212 13 0 13 0 17
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_a - 0.39 0.31 0.50 5 1118 5 2 3 0 11
3J16_L 0.82 0.67 1.00 20 2755 0 0 0 0 10
3J20_0 0.67 0.57 0.81 17 2829 5 1 3 1 13
3J20_1 0.71 0.70 0.73 16 2904 6 0 6 0 7
3J2C_O - 0.30 0.24 0.39 15 10258 24 0 23 1 48
3J2L_3 0.56 0.45 0.71 24 7841 13 1 9 3 29
3JYV_7 -0.01 0.00 0.00 0 2831 19 0 19 0 32
3JYX_4 0.31 0.30 0.31 10 12214 32 3 19 10 23
3JYX_3 0.17 0.15 0.20 4 6308 18 4 12 2 23
3KTW_C - 0.38 0.30 0.50 13 4534 13 3 10 0 30
3LA5_A -0.01 0.00 0.00 0 2469 16 0 16 0 34
3NDB_M - 0.06 0.05 0.08 3 9144 33 1 32 0 58
3NKB_B - 0.59 0.54 0.67 14 1995 7 0 7 0 12
3NMU_E - 0.20 0.17 0.25 1 557 5 0 3 2 5
3NPB_A 0.57 0.46 0.72 21 6992 9 1 7 1 25
3O58_3 0.39 0.37 0.41 13 12371 28 7 12 9 22
3O58_2 0.45 0.42 0.48 16 7227 19 3 14 2 22
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.57 0.44 0.74 32 12837 13 0 11 2 40
3R4F_A - 0.94 0.88 1.00 22 2123 0 0 0 0 3
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.75 0.65 0.88 22 2186 3 0 3 0 12
3SD1_A 0.11 0.10 0.15 4 3890 22 0 22 0 38
3SIU_F - 0.73 0.55 1.00 6 372 0 0 0 0 5
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.38 0.32 0.46 12 3134 14 0 14 0 25
3UZL_B 0.16 0.14 0.20 5 3545 20 1 19 0 32
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.76 0.70 0.82 28 4719 7 1 5 1 12
3ZEX_D 0.08 0.06 0.11 3 6994 24 0 24 0 46
3ZEX_E - 0.07 0.06 0.08 5 21886 54 5 49 0 72
4A1C_3 0.26 0.22 0.32 12 7103 25 2 23 0 42
4A1C_2 0.24 0.24 0.24 8 11748 37 3 22 12 25
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.18 0.14 0.25 6 4347 19 1 17 1 36
4ATO_G - 0.56 0.60 0.55 6 517 5 1 4 0 4
4ENB_A 0.89 0.79 1.00 15 1260 0 0 0 0 4
4ENC_A 0.86 0.79 0.94 15 1310 1 1 0 0 4
4FRG_B 0.56 0.47 0.68 15 3464 7 1 6 0 17
4FRN_A 0.13 0.11 0.17 4 5128 19 2 17 0 32

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.