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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAshapes - scored higher in this pairwise comparison

  4. Performance of CMfinder(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAshapes & CMfinder(20) [.zip] - may take several seconds...


Overview

Metric RNAshapes CMfinder(20)
MCC 0.556 > 0.546
Average MCC ± 95% Confidence Intervals 0.525 ± 0.304 < 0.560 ± 0.222
Sensitivity 0.482 > 0.366
Positive Predictive Value 0.648 < 0.822
Total TP 79 > 60
Total TN 21110 < 21159
Total FP 46 > 15
Total FP CONTRA 0 < 1
Total FP INCONS 43 > 12
Total FP COMP 3 > 2
Total FN 85 < 104
P-value 0.0

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Performance plots


  1. Comparison of performance of RNAshapes and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAshapes and CMfinder(20)).

  2. Comparison of performance of RNAshapes and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAshapes and CMfinder(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAshapes and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAshapes and CMfinder(20)).

  4. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAshapes and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAshapes and CMfinder(20)).

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Performance of RNAshapes - scored higher in this pairwise comparison

1. Total counts & total scores for RNAshapes

Total Base Pair Counts
Total TP 79
Total TN 21110
Total FP 46
Total FP CONTRA 0
Total FP INCONS 43
Total FP COMP 3
Total FN 85
Total Scores
MCC 0.556
Average MCC ± 95% Confidence Intervals 0.525 ± 0.304
Sensitivity 0.482
Positive Predictive Value 0.648
Nr of predictions 4

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2. Individual counts for RNAshapes [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.43 0.40 0.48 12 2825 14 0 13 1 18
3J2L_3 0.59 0.51 0.69 27 7836 14 0 12 2 26
3ZEX_D 0.76 0.63 0.91 31 6987 3 0 3 0 18
4FRG_B 0.32 0.28 0.38 9 3462 15 0 15 0 23

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Performance of CMfinder(20) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 60
Total TN 21159
Total FP 15
Total FP CONTRA 1
Total FP INCONS 12
Total FP COMP 2
Total FN 104
Total Scores
MCC 0.546
Average MCC ± 95% Confidence Intervals 0.560 ± 0.222
Sensitivity 0.366
Positive Predictive Value 0.822
Nr of predictions 4

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.75 0.57 1.00 17 2833 1 0 0 1 13
3J2L_3 0.45 0.32 0.63 17 7848 11 1 9 1 36
3ZEX_D 0.58 0.39 0.86 19 6999 3 0 3 0 30
4FRG_B 0.47 0.22 1.00 7 3479 0 0 0 0 25

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.