CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAshapes - scored higher in this pairwise comparison

  4. Performance of Vsfold4 - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAshapes & Vsfold4 [.zip] - may take several seconds...


Overview

Metric RNAshapes Vsfold4
MCC 0.624 > 0.547
Average MCC ± 95% Confidence Intervals 0.689 ± 0.050 > 0.621 ± 0.054
Sensitivity 0.555 > 0.465
Positive Predictive Value 0.706 > 0.650
Total TP 1812 > 1518
Total TN 477996 < 478227
Total FP 889 < 905
Total FP CONTRA 88 > 82
Total FP INCONS 667 < 736
Total FP COMP 134 > 87
Total FN 1453 < 1747
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of RNAshapes and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAshapes and Vsfold4).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAshapes and Vsfold4).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAshapes and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAshapes and Vsfold4).

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Performance of RNAshapes - scored higher in this pairwise comparison

1. Total counts & total scores for RNAshapes

Total Base Pair Counts
Total TP 1812
Total TN 477996
Total FP 889
Total FP CONTRA 88
Total FP INCONS 667
Total FP COMP 134
Total FN 1453
Total Scores
MCC 0.624
Average MCC ± 95% Confidence Intervals 0.689 ± 0.050
Sensitivity 0.555
Positive Predictive Value 0.706
Nr of predictions 129

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2. Individual counts for RNAshapes [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 395 0 0 0 0 0
2K63_A - 0.95 0.90 1.00 9 397 0 0 0 0 1
2K66_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KEZ_A - 0.89 0.80 1.00 8 268 0 0 0 0 2
2KFC_A - -0.02 0.00 0.00 0 623 7 0 7 0 20
2KGP_A - 1.00 1.00 1.00 9 291 1 0 0 1 0
2KMJ_A - 1.00 1.00 1.00 11 367 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.76 0.60 0.96 24 5126 5 0 1 4 16
2KU0_A - 0.83 0.69 1.00 11 692 0 0 0 0 5
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KX8_A 0.91 0.83 1.00 15 846 0 0 0 0 3
2KXM_A - 0.83 0.70 1.00 7 344 0 0 0 0 3
2KZL_A - 0.86 0.74 1.00 14 1471 0 0 0 0 5
2L1F_B 0.96 0.92 1.00 23 2122 0 0 0 0 2
2L1F_A 0.87 0.83 0.91 20 2058 2 0 2 0 4
2L2K_A - 0.92 0.84 1.00 16 845 0 0 0 0 3
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.92 0.85 1.00 29 2456 0 0 0 0 5
2L5Z_A - 0.86 0.75 1.00 9 316 0 0 0 0 3
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LA5_A - 0.39 0.26 0.63 5 622 3 1 2 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A 0.61 0.55 0.69 11 1524 5 0 5 0 9
2LDL_A - 0.90 0.82 1.00 9 342 1 0 0 1 2
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.93 0.87 1.00 34 6071 1 0 0 1 5
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LWK_A - 0.83 0.77 0.91 10 485 1 0 1 0 3
2RP0_A - 0.64 0.42 1.00 5 346 0 0 0 0 7
2RPT_A - 1.00 1.00 1.00 7 183 0 0 0 0 0
2RRC_A - 0.70 0.50 1.00 5 226 0 0 0 0 5
2WRQ_Y 0.59 0.59 0.59 10 2833 12 4 3 5 7
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WW9_D - 0.16 0.12 0.25 3 1941 9 4 5 0 23
2WW9_E - 0.53 0.29 1.00 4 557 0 0 0 0 10
2WWQ_V 0.76 0.68 0.86 19 2904 5 0 3 2 9
2XKV_B 0.51 0.50 0.53 10 4541 22 0 9 13 10
2XQD_Y 0.64 0.56 0.75 15 2830 5 0 5 0 12
2XXA_G 0.93 0.86 1.00 36 5115 0 0 0 0 6
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.65 0.63 0.68 15 2256 8 1 6 1 9
2YIE_X - 0.25 0.25 0.27 3 1367 11 1 7 3 9
2YIE_Z - -0.01 0.00 0.00 0 1525 15 3 12 0 12
2ZY6_A - 0.58 0.58 0.58 7 691 5 0 5 0 5
2ZZM_B 0.10 0.09 0.12 3 3460 23 0 23 0 29
2ZZN_D 0.69 0.63 0.77 17 2463 5 1 4 0 10
3A2K_C 0.42 0.39 0.46 11 2902 13 2 11 0 17
3A3A_A 0.76 0.65 0.89 24 3628 3 0 3 0 13
3ADB_C - 0.67 0.61 0.74 23 4155 8 0 8 0 15
3AKZ_H 0.68 0.61 0.77 17 2679 6 1 4 1 11
3AM1_B - 0.64 0.60 0.70 21 3210 9 1 8 0 14
3AMU_B 0.70 0.59 0.84 16 2984 5 0 3 2 11
3DW4_A - -0.02 0.00 0.00 0 348 3 0 3 0 10
3G4S_9 0.41 0.32 0.53 18 7347 16 1 15 0 39
3GCA_A - 0.54 0.29 1.00 5 523 0 0 0 0 12
3GX2_A 0.76 0.63 0.93 25 4344 3 0 2 1 15
3HAY_E - 0.91 0.83 1.00 15 2263 4 0 0 4 3
3HJW_D - 0.94 0.89 1.00 16 1637 0 0 0 0 2
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3ID5_D - 0.44 0.33 0.60 3 491 5 0 2 3 6
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IWN_A 0.76 0.67 0.88 22 4253 3 0 3 0 11
3IYQ_A 0.26 0.28 0.24 26 60619 83 21 60 2 68
3IZ4_A 0.52 0.45 0.60 60 70776 45 6 34 5 72
3IZF_C 0.59 0.52 0.68 28 6862 13 1 12 0 26
3J0L_1 - 0.76 0.63 0.92 12 1212 2 0 1 1 7
3J0L_2 - 0.38 0.36 0.40 12 6186 20 3 15 2 21
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_a - 0.23 0.19 0.30 3 1118 7 1 6 0 13
3J0L_7 - -0.01 0.00 0.00 0 1213 12 0 12 0 17
3J0L_h - 0.75 0.60 0.93 26 6077 4 0 2 2 17
3J16_L 0.50 0.40 0.63 12 2756 7 0 7 0 18
3J20_1 0.96 0.91 1.00 21 2905 0 0 0 0 2
3J20_0 0.43 0.40 0.48 12 2825 14 0 13 1 18
3J2C_O - 0.39 0.33 0.47 21 10251 24 0 24 0 42
3J2L_3 0.59 0.51 0.69 27 7836 14 0 12 2 26
3JYV_7 -0.01 0.00 0.00 0 2830 20 0 20 0 32
3JYX_3 0.63 0.63 0.63 17 6301 21 1 9 11 10
3JYX_4 0.31 0.30 0.31 10 12214 35 5 17 13 23
3KTW_C - 0.39 0.35 0.45 15 4527 19 1 17 1 28
3LA5_A 0.76 0.59 1.00 20 2465 0 0 0 0 14
3NDB_M - 0.82 0.72 0.94 44 9133 4 0 3 1 17
3NKB_B - 0.61 0.54 0.70 14 1996 6 0 6 0 12
3NMU_E - 0.54 0.50 0.60 3 556 5 0 2 3 3
3NPB_A 0.77 0.63 0.94 29 6990 4 1 1 2 17
3O58_3 0.34 0.34 0.34 12 12368 37 2 21 14 23
3O58_2 0.60 0.61 0.59 23 7221 18 4 12 2 15
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.67 0.56 0.80 40 12830 12 0 10 2 32
3R4F_A - 0.96 0.92 1.00 23 2122 0 0 0 0 2
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.64 0.52 0.79 22 3888 6 1 5 0 20
3SIU_F - 0.85 0.73 1.00 8 370 0 0 0 0 3
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.38 0.32 0.46 12 3134 14 0 14 0 25
3UZL_B 0.39 0.32 0.48 12 3545 13 2 11 0 25
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.55 0.48 0.63 19 4723 12 1 10 1 21
3ZEX_D 0.76 0.63 0.91 31 6987 3 0 3 0 18
3ZEX_G - 0.52 0.45 0.61 33 16417 24 2 19 3 41
3ZEX_E - 0.00 0.00 0.00 0 21888 59 3 54 2 77
4A1C_3 0.68 0.57 0.82 31 7102 7 1 6 0 23
4A1C_2 0.14 0.15 0.14 5 11746 41 5 25 11 28
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.50 0.40 0.63 17 4344 11 2 8 1 25
4ATO_G - 0.32 0.30 0.38 3 520 5 1 4 0 7
4ENB_A 0.70 0.58 0.85 11 1262 2 1 1 0 8
4ENC_A 0.32 0.26 0.42 5 1314 7 1 6 0 14
4FRG_B 0.32 0.28 0.38 9 3462 15 0 15 0 23
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0

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Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 1518
Total TN 478227
Total FP 905
Total FP CONTRA 82
Total FP INCONS 736
Total FP COMP 87
Total FN 1747
Total Scores
MCC 0.547
Average MCC ± 95% Confidence Intervals 0.621 ± 0.054
Sensitivity 0.465
Positive Predictive Value 0.650
Nr of predictions 129

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.37 0.36 0.40 4 396 6 0 6 0 7
2K63_A - 0.95 0.90 1.00 9 397 0 0 0 0 1
2K66_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KEZ_A - 0.70 0.50 1.00 5 271 0 0 0 0 5
2KFC_A - 0.49 0.25 1.00 5 625 0 0 0 0 15
2KGP_A - -0.02 0.00 0.00 0 296 4 0 4 0 9
2KMJ_A - 1.00 1.00 1.00 11 367 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.65 0.53 0.81 21 5125 7 0 5 2 19
2KU0_A - -0.02 0.00 0.00 0 694 9 0 9 0 16
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2KXM_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
2KZL_A - 0.86 0.74 1.00 14 1471 0 0 0 0 5
2L1F_B 0.68 0.56 0.82 14 2128 3 0 3 0 11
2L1F_A 0.66 0.54 0.81 13 2064 3 0 3 0 11
2L2K_A - 0.89 0.79 1.00 15 846 0 0 0 0 4
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.87 0.76 1.00 26 2459 0 0 0 0 8
2L5Z_A - 0.60 0.50 0.75 6 317 2 0 2 0 6
2L94_A 0.92 0.85 1.00 17 973 0 0 0 0 3
2LA5_A - 0.46 0.26 0.83 5 624 1 0 1 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A -0.01 0.00 0.00 0 1527 13 0 13 0 20
2LDL_A - 0.85 0.73 1.00 8 343 1 0 0 1 3
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.31 0.28 0.34 11 6073 21 3 18 0 28
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LWK_A - 0.83 0.77 0.91 10 485 1 0 1 0 3
2RP0_A - 0.64 0.42 1.00 5 346 0 0 0 0 7
2RPT_A - -0.03 0.00 0.00 0 186 4 0 4 0 7
2RRC_A - 0.70 0.50 1.00 5 226 0 0 0 0 5
2WRQ_Y 0.53 0.53 0.53 9 2833 12 5 3 4 8
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WW9_D - 0.19 0.12 0.33 3 1944 6 0 6 0 23
2WW9_E - -0.01 0.00 0.00 0 556 5 0 5 0 14
2WWQ_V 0.64 0.50 0.82 14 2909 4 0 3 1 14
2XKV_B -0.01 0.00 0.00 0 4533 27 8 19 0 20
2XQD_Y 0.86 0.74 1.00 20 2830 0 0 0 0 7
2XXA_G -0.01 0.00 0.00 0 5122 29 1 28 0 42
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.63 0.50 0.80 12 2263 4 0 3 1 12
2YIE_X - 0.36 0.33 0.40 4 1368 6 2 4 0 8
2YIE_Z - -0.01 0.00 0.00 0 1529 11 3 8 0 12
2ZY6_A - 0.58 0.58 0.58 7 691 5 1 4 0 5
2ZZM_B 0.21 0.19 0.24 6 3461 19 0 19 0 26
2ZZN_D 0.86 0.78 0.95 21 2463 1 0 1 0 6
3A2K_C 0.84 0.71 1.00 20 2906 0 0 0 0 8
3A3A_A 0.85 0.73 1.00 27 3628 0 0 0 0 10
3ADB_C - 0.89 0.79 1.00 30 4156 0 0 0 0 8
3AKZ_H 0.67 0.57 0.80 16 2681 5 1 3 1 12
3AM1_B - 0.84 0.71 1.00 25 3215 0 0 0 0 10
3AMU_B 0.64 0.56 0.75 15 2983 7 0 5 2 12
3DW4_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
3G4S_9 0.30 0.23 0.39 13 7348 20 1 19 0 44
3GCA_A - 0.54 0.29 1.00 5 523 0 0 0 0 12
3GX2_A 0.50 0.40 0.64 16 4346 10 0 9 1 24
3HAY_E - 0.91 0.83 1.00 15 2263 3 0 0 3 3
3HJW_D - 0.51 0.50 0.53 9 1636 8 0 8 0 9
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3ID5_D - 0.44 0.33 0.60 3 491 4 0 2 2 6
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IWN_A 0.27 0.21 0.35 7 4258 13 1 12 0 26
3IYQ_A 0.29 0.29 0.29 27 60634 71 13 52 6 67
3IZ4_A 0.36 0.31 0.43 41 70780 59 7 48 4 91
3IZF_C 0.69 0.56 0.86 30 6868 5 0 5 0 24
3J0L_1 - 0.28 0.21 0.40 4 1215 6 1 5 0 15
3J0L_2 - 0.38 0.36 0.41 12 6187 18 3 14 1 21
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_8 - 0.70 0.50 1.00 4 186 0 0 0 0 4
3J0L_a - 0.39 0.31 0.50 5 1118 5 2 3 0 11
3J0L_7 - 0.51 0.41 0.64 7 1214 4 0 4 0 10
3J0L_h - 0.38 0.28 0.52 12 6082 11 0 11 0 31
3J16_L 0.82 0.67 1.00 20 2755 0 0 0 0 10
3J20_1 0.71 0.70 0.73 16 2904 6 0 6 0 7
3J20_0 0.84 0.70 1.00 21 2829 1 0 0 1 9
3J2C_O - 0.30 0.24 0.39 15 10258 24 0 23 1 48
3J2L_3 0.57 0.45 0.73 24 7842 12 1 8 3 29
3JYV_7 -0.01 0.00 0.00 0 2831 19 0 19 0 32
3JYX_3 0.60 0.56 0.65 15 6305 11 4 4 3 12
3JYX_4 0.10 0.09 0.12 3 12220 33 2 21 10 30
3KTW_C - 0.36 0.28 0.48 12 4535 13 3 10 0 31
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.28 0.23 0.35 14 9140 26 0 26 0 47
3NKB_B - 0.59 0.54 0.67 14 1995 7 0 7 0 12
3NMU_E - 0.41 0.17 1.00 1 560 3 0 0 3 5
3NPB_A 0.61 0.50 0.74 23 6990 9 0 8 1 23
3O58_3 0.09 0.09 0.10 3 12373 35 5 22 8 32
3O58_2 0.47 0.42 0.53 16 7230 16 3 11 2 22
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.57 0.44 0.74 32 12837 13 0 11 2 40
3R4F_A - 0.94 0.88 1.00 22 2123 0 0 0 0 3
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.19 0.17 0.24 7 3887 22 1 21 0 35
3SIU_F - 0.73 0.55 1.00 6 372 0 0 0 0 5
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.38 0.32 0.46 12 3134 14 0 14 0 25
3UZL_B 0.53 0.41 0.71 15 3549 6 1 5 0 22
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.67 0.58 0.79 23 4724 7 0 6 1 17
3ZEX_D 0.55 0.45 0.69 22 6989 10 0 10 0 27
3ZEX_G - 0.30 0.23 0.39 17 16427 27 2 25 0 57
3ZEX_E - 0.08 0.06 0.11 5 21900 40 1 39 0 72
4A1C_3 0.26 0.22 0.32 12 7103 25 2 23 0 42
4A1C_2 0.28 0.24 0.33 8 11757 28 0 16 12 25
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.42 0.33 0.54 14 4345 13 1 11 1 28
4ATO_G - 0.32 0.30 0.38 3 520 5 1 4 0 7
4ENB_A 0.76 0.58 1.00 11 1264 0 0 0 0 8
4ENC_A 0.69 0.47 1.00 9 1317 0 0 0 0 10
4FRG_B 0.56 0.47 0.68 15 3464 7 1 6 0 17
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.