CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAsubopt - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAsubopt & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric RNAsubopt Carnac(seed)
MCC 0.614 > 0.241
Average MCC ± 95% Confidence Intervals 0.636 ± 0.091 > 0.141 ± 0.103
Sensitivity 0.553 > 0.058
Positive Predictive Value 0.686 < 1.000
Total TP 617 > 65
Total TN 159117 < 159951
Total FP 354 > 0
Total FP CONTRA 39 > 0
Total FP INCONS 243 > 0
Total FP COMP 72 > 0
Total FN 499 < 1051
P-value 5.23657817852e-08

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Performance plots


  1. Comparison of performance of RNAsubopt and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAsubopt and Carnac(seed)).

  2. Comparison of performance of RNAsubopt and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAsubopt and Carnac(seed)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAsubopt and Carnac(seed)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAsubopt and Carnac(seed)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAsubopt and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAsubopt and Carnac(seed)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAsubopt and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAsubopt and Carnac(seed)).

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Performance of RNAsubopt - scored higher in this pairwise comparison

1. Total counts & total scores for RNAsubopt

Total Base Pair Counts
Total TP 617
Total TN 159117
Total FP 354
Total FP CONTRA 39
Total FP INCONS 243
Total FP COMP 72
Total FN 499
Total Scores
MCC 0.614
Average MCC ± 95% Confidence Intervals 0.636 ± 0.091
Sensitivity 0.553
Positive Predictive Value 0.686
Nr of predictions 34

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2. Individual counts for RNAsubopt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.86 0.84 0.89 16 1110 3 0 2 1 3
2KUR_A 0.85 0.81 0.89 17 1109 2 0 2 0 4
2KUU_A 0.82 0.76 0.89 16 1110 3 0 2 1 5
2KUV_A 0.83 0.77 0.89 17 1109 2 0 2 0 5
2KUW_A 0.90 0.86 0.95 18 1109 1 0 1 0 3
2L1F_A 0.93 0.88 1.00 21 2059 0 0 0 0 3
2L1F_B 0.94 0.88 1.00 22 2123 0 0 0 0 3
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
2XKV_B 0.51 0.50 0.53 10 4541 23 0 9 14 10
2XXA_G 0.47 0.43 0.53 18 5117 16 1 15 0 24
3A3A_A 0.87 0.76 1.00 28 3627 0 0 0 0 9
3GX2_A 0.44 0.38 0.54 15 4343 14 1 12 1 25
3IVN_B 0.76 0.58 1.00 18 2328 0 0 0 0 13
3IZF_C 0.70 0.61 0.80 33 6862 8 1 7 0 21
3JYX_4 0.19 0.21 0.17 7 12204 38 11 24 3 26
3JYX_3 0.63 0.63 0.63 17 6301 21 1 9 11 10
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NPB_A 0.75 0.65 0.86 30 6986 7 1 4 2 16
3O58_3 0.34 0.34 0.34 12 12368 34 2 21 11 23
3O58_2 0.72 0.74 0.70 28 7220 13 4 8 1 10
3PDR_A 0.75 0.63 0.90 45 12830 7 1 4 2 27
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.61 0.50 0.75 21 3888 7 1 6 0 21
3W3S_B 0.87 0.78 0.97 31 4721 2 0 1 1 9
3ZEX_C 0.24 0.21 0.28 11 14157 42 1 27 14 41
4A1C_2 0.14 0.15 0.13 5 11742 43 5 29 9 28
4A1C_3 0.70 0.59 0.82 32 7101 7 1 6 0 22
4AOB_A 0.52 0.43 0.64 18 4343 11 2 8 1 24
4ENB_A 0.70 0.58 0.85 11 1262 2 1 1 0 8
4ENC_A 0.32 0.26 0.42 5 1314 7 0 7 0 14
4FRG_B 0.32 0.28 0.38 9 3462 15 0 15 0 23
4FRN_A 0.51 0.44 0.59 16 5124 11 3 8 0 20

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 65
Total TN 159951
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 1051
Total Scores
MCC 0.241
Average MCC ± 95% Confidence Intervals 0.141 ± 0.103
Sensitivity 0.058
Positive Predictive Value 1.000
Nr of predictions 34

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.00 0.00 0.00 0 1128 0 0 0 0 19
2KUR_A 0.57 0.33 1.00 7 1121 0 0 0 0 14
2KUU_A 0.57 0.33 1.00 7 1121 0 0 0 0 14
2KUV_A 0.64 0.41 1.00 9 1119 0 0 0 0 13
2KUW_A 0.65 0.43 1.00 9 1119 0 0 0 0 12
2L1F_A 0.00 0.00 0.00 0 2080 0 0 0 0 24
2L1F_B 0.00 0.00 0.00 0 2145 0 0 0 0 25
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LC8_A 0.44 0.20 1.00 4 1536 0 0 0 0 16
2XKV_B 0.00 0.00 0.00 0 4560 0 0 0 0 20
2XXA_G 0.00 0.00 0.00 0 5151 0 0 0 0 42
3A3A_A 0.00 0.00 0.00 0 3655 0 0 0 0 37
3GX2_A 0.00 0.00 0.00 0 4371 0 0 0 0 40
3IVN_B 0.00 0.00 0.00 0 2346 0 0 0 0 31
3IZF_C 0.00 0.00 0.00 0 6903 0 0 0 0 54
3JYX_4 0.00 0.00 0.00 0 12246 0 0 0 0 33
3JYX_3 0.00 0.00 0.00 0 6328 0 0 0 0 27
3LA5_A 0.00 0.00 0.00 0 2485 0 0 0 0 34
3NPB_A 0.00 0.00 0.00 0 7021 0 0 0 0 46
3O58_3 0.00 0.00 0.00 0 12403 0 0 0 0 35
3O58_2 0.00 0.00 0.00 0 7260 0 0 0 0 38
3PDR_A 0.00 0.00 0.00 0 12880 0 0 0 0 72
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
3W3S_B 0.00 0.00 0.00 0 4753 0 0 0 0 40
3ZEX_C 0.00 0.00 0.00 0 14196 0 0 0 0 52
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32
4FRN_A 0.00 0.00 0.00 0 5151 0 0 0 0 36

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.