CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAsubopt - scored higher in this pairwise comparison

  4. Performance of Vsfold4 - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAsubopt & Vsfold4 [.zip] - may take several seconds...


Overview

Metric RNAsubopt Vsfold4
MCC 0.618 > 0.547
Average MCC ± 95% Confidence Intervals 0.680 ± 0.052 > 0.621 ± 0.054
Sensitivity 0.557 > 0.465
Positive Predictive Value 0.691 > 0.650
Total TP 1818 > 1518
Total TN 477933 < 478227
Total FP 934 > 905
Total FP CONTRA 102 > 82
Total FP INCONS 710 < 736
Total FP COMP 122 > 87
Total FN 1447 < 1747
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of RNAsubopt and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAsubopt and Vsfold4).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAsubopt and Vsfold4).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAsubopt and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAsubopt and Vsfold4).

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Performance of RNAsubopt - scored higher in this pairwise comparison

1. Total counts & total scores for RNAsubopt

Total Base Pair Counts
Total TP 1818
Total TN 477933
Total FP 934
Total FP CONTRA 102
Total FP INCONS 710
Total FP COMP 122
Total FN 1447
Total Scores
MCC 0.618
Average MCC ± 95% Confidence Intervals 0.680 ± 0.052
Sensitivity 0.557
Positive Predictive Value 0.691
Nr of predictions 129

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2. Individual counts for RNAsubopt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.95 0.91 1.00 10 396 0 0 0 0 1
2K63_A - 0.89 0.80 1.00 8 398 0 0 0 0 2
2K66_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2KD8_A - 0.88 0.78 1.00 7 224 0 0 0 0 2
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.86 0.84 0.89 16 1110 3 0 2 1 3
2KEZ_A - 0.89 0.80 1.00 8 268 0 0 0 0 2
2KFC_A - -0.02 0.00 0.00 0 623 7 0 7 0 20
2KGP_A - 1.00 1.00 1.00 9 291 0 0 0 0 0
2KMJ_A - 1.00 1.00 1.00 11 367 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.52 0.43 0.65 17 5125 12 3 6 3 23
2KU0_A - 0.83 0.69 1.00 11 692 0 0 0 0 5
2KUR_A 0.85 0.81 0.89 17 1109 2 0 2 0 4
2KUU_A 0.82 0.76 0.89 16 1110 3 0 2 1 5
2KUV_A 0.83 0.77 0.89 17 1109 2 0 2 0 5
2KUW_A 0.90 0.86 0.95 18 1109 1 0 1 0 3
2KX8_A 0.91 0.83 1.00 15 846 0 0 0 0 3
2KXM_A - 0.89 0.80 1.00 8 343 0 0 0 0 2
2KZL_A - 0.86 0.74 1.00 14 1471 0 0 0 0 5
2L1F_B 0.94 0.88 1.00 22 2123 0 0 0 0 3
2L1F_A 0.93 0.88 1.00 21 2059 0 0 0 0 3
2L2K_A - 0.94 0.89 1.00 17 844 0 0 0 0 2
2L3C_B - 0.87 0.76 1.00 13 548 0 0 0 0 4
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.94 0.88 1.00 30 2455 0 0 0 0 4
2L5Z_A - 0.86 0.75 1.00 9 316 0 0 0 0 3
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LA5_A - 0.39 0.26 0.63 5 622 3 1 2 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
2LDL_A - 0.90 0.82 1.00 9 342 1 0 0 1 2
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.81 0.77 0.86 30 6070 9 0 5 4 9
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LWK_A - 0.83 0.77 0.91 10 485 1 0 1 0 3
2RP0_A - 0.64 0.42 1.00 5 346 0 0 0 0 7
2RPT_A - 1.00 1.00 1.00 7 183 0 0 0 0 0
2RRC_A - 0.83 0.70 1.00 7 224 0 0 0 0 3
2WRQ_Y 0.57 0.59 0.56 10 2832 12 5 3 4 7
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WW9_D - 0.15 0.12 0.21 3 1939 11 4 7 0 23
2WW9_E - -0.01 0.00 0.00 0 556 5 0 5 0 14
2WWQ_V 0.76 0.68 0.86 19 2904 5 0 3 2 9
2XKV_B 0.51 0.50 0.53 10 4541 23 0 9 14 10
2XQD_Y 0.75 0.67 0.86 18 2829 3 0 3 0 9
2XXA_G 0.47 0.43 0.53 18 5117 16 1 15 0 24
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.66 0.63 0.71 15 2257 8 1 5 2 9
2YIE_X - 0.82 0.67 1.00 8 1370 3 0 0 3 4
2YIE_Z - -0.01 0.00 0.00 0 1525 15 3 12 0 12
2ZY6_A - 0.58 0.58 0.58 7 691 5 1 4 0 5
2ZZM_B 0.23 0.22 0.26 7 3459 20 2 18 0 25
2ZZN_D 0.48 0.44 0.52 12 2462 11 1 10 0 15
3A2K_C 0.42 0.39 0.46 11 2902 13 2 11 0 17
3A3A_A 0.87 0.76 1.00 28 3627 0 0 0 0 9
3ADB_C - 0.92 0.84 1.00 32 4154 0 0 0 0 6
3AKZ_H 0.39 0.36 0.43 10 2678 13 2 11 0 18
3AM1_B - 0.91 0.83 1.00 29 3211 0 0 0 0 6
3AMU_B 0.70 0.59 0.84 16 2984 5 0 3 2 11
3DW4_A - -0.02 0.00 0.00 0 345 6 0 6 0 10
3G4S_9 0.28 0.23 0.35 13 7344 24 1 23 0 44
3GCA_A - 0.54 0.29 1.00 5 523 0 0 0 0 12
3GX2_A 0.44 0.38 0.54 15 4343 14 1 12 1 25
3HAY_E - 0.91 0.83 1.00 15 2263 3 0 0 3 3
3HJW_D - 0.91 0.83 1.00 15 1638 2 0 0 2 3
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3ID5_D - 0.40 0.33 0.50 3 490 5 0 3 2 6
3IVN_B 0.76 0.58 1.00 18 2328 0 0 0 0 13
3IWN_A 0.63 0.58 0.70 19 4251 9 0 8 1 14
3IYQ_A 0.33 0.36 0.30 34 60614 82 17 61 4 60
3IZ4_A 0.51 0.47 0.56 62 70766 49 8 40 1 70
3IZF_C 0.70 0.61 0.80 33 6862 8 1 7 0 21
3J0L_1 - 0.76 0.63 0.92 12 1212 2 0 1 1 7
3J0L_2 - 0.25 0.24 0.28 8 6187 25 0 21 4 25
3J0L_g - -0.01 0.00 0.00 0 460 5 1 4 0 4
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_a - 0.35 0.31 0.42 5 1116 7 1 6 0 11
3J0L_7 - -0.01 0.00 0.00 0 1213 12 0 12 0 17
3J0L_h - 0.75 0.60 0.93 26 6077 4 0 2 2 17
3J16_L 0.41 0.37 0.48 11 2752 12 1 11 0 19
3J20_1 0.96 0.91 1.00 21 2905 2 0 0 2 2
3J20_0 0.43 0.40 0.48 12 2825 14 0 13 1 18
3J2C_O - 0.56 0.49 0.65 31 10248 17 1 16 0 32
3J2L_3 0.61 0.53 0.72 28 7836 13 0 11 2 25
3JYV_7 -0.01 0.00 0.00 0 2829 21 0 21 0 32
3JYX_3 0.63 0.63 0.63 17 6301 21 1 9 11 10
3JYX_4 0.19 0.21 0.17 7 12204 38 11 24 3 26
3KTW_C - 0.75 0.65 0.88 28 4528 5 2 2 1 15
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.77 0.69 0.86 42 9131 8 0 7 1 19
3NKB_B - 0.57 0.50 0.65 13 1996 7 0 7 0 13
3NMU_E - 0.54 0.50 0.60 3 556 5 0 2 3 3
3NPB_A 0.75 0.65 0.86 30 6986 7 1 4 2 16
3O58_3 0.34 0.34 0.34 12 12368 34 2 21 11 23
3O58_2 0.72 0.74 0.70 28 7220 13 4 8 1 10
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.75 0.63 0.90 45 12830 7 1 4 2 27
3R4F_A - 0.96 0.92 1.00 23 2122 0 0 0 0 2
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.61 0.50 0.75 21 3888 7 1 6 0 21
3SIU_F - 0.85 0.73 1.00 8 370 0 0 0 0 3
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.38 0.32 0.46 12 3134 14 0 14 0 25
3UZL_B 0.48 0.38 0.61 14 3547 9 0 9 0 23
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.87 0.78 0.97 31 4721 2 0 1 1 9
3ZEX_D 0.80 0.69 0.92 34 6984 3 0 3 0 15
3ZEX_G - 0.46 0.42 0.52 31 16411 32 3 26 3 43
3ZEX_E - 0.00 0.00 0.00 0 21893 54 4 48 2 77
4A1C_3 0.70 0.59 0.82 32 7101 7 1 6 0 22
4A1C_2 0.14 0.15 0.13 5 11742 43 5 29 9 28
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.52 0.43 0.64 18 4343 11 2 8 1 24
4ATO_G - 0.30 0.30 0.33 3 519 6 2 4 0 7
4ENB_A 0.70 0.58 0.85 11 1262 2 1 1 0 8
4ENC_A 0.32 0.26 0.42 5 1314 7 0 7 0 14
4FRG_B 0.32 0.28 0.38 9 3462 15 0 15 0 23
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0

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Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 1518
Total TN 478227
Total FP 905
Total FP CONTRA 82
Total FP INCONS 736
Total FP COMP 87
Total FN 1747
Total Scores
MCC 0.547
Average MCC ± 95% Confidence Intervals 0.621 ± 0.054
Sensitivity 0.465
Positive Predictive Value 0.650
Nr of predictions 129

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.37 0.36 0.40 4 396 6 0 6 0 7
2K63_A - 0.95 0.90 1.00 9 397 0 0 0 0 1
2K66_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KEZ_A - 0.70 0.50 1.00 5 271 0 0 0 0 5
2KFC_A - 0.49 0.25 1.00 5 625 0 0 0 0 15
2KGP_A - -0.02 0.00 0.00 0 296 4 0 4 0 9
2KMJ_A - 1.00 1.00 1.00 11 367 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.65 0.53 0.81 21 5125 7 0 5 2 19
2KU0_A - -0.02 0.00 0.00 0 694 9 0 9 0 16
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2KXM_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
2KZL_A - 0.86 0.74 1.00 14 1471 0 0 0 0 5
2L1F_B 0.68 0.56 0.82 14 2128 3 0 3 0 11
2L1F_A 0.66 0.54 0.81 13 2064 3 0 3 0 11
2L2K_A - 0.89 0.79 1.00 15 846 0 0 0 0 4
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.87 0.76 1.00 26 2459 0 0 0 0 8
2L5Z_A - 0.60 0.50 0.75 6 317 2 0 2 0 6
2L94_A 0.92 0.85 1.00 17 973 0 0 0 0 3
2LA5_A - 0.46 0.26 0.83 5 624 1 0 1 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A -0.01 0.00 0.00 0 1527 13 0 13 0 20
2LDL_A - 0.85 0.73 1.00 8 343 1 0 0 1 3
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.31 0.28 0.34 11 6073 21 3 18 0 28
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LWK_A - 0.83 0.77 0.91 10 485 1 0 1 0 3
2RP0_A - 0.64 0.42 1.00 5 346 0 0 0 0 7
2RPT_A - -0.03 0.00 0.00 0 186 4 0 4 0 7
2RRC_A - 0.70 0.50 1.00 5 226 0 0 0 0 5
2WRQ_Y 0.53 0.53 0.53 9 2833 12 5 3 4 8
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WW9_D - 0.19 0.12 0.33 3 1944 6 0 6 0 23
2WW9_E - -0.01 0.00 0.00 0 556 5 0 5 0 14
2WWQ_V 0.64 0.50 0.82 14 2909 4 0 3 1 14
2XKV_B -0.01 0.00 0.00 0 4533 27 8 19 0 20
2XQD_Y 0.86 0.74 1.00 20 2830 0 0 0 0 7
2XXA_G -0.01 0.00 0.00 0 5122 29 1 28 0 42
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.63 0.50 0.80 12 2263 4 0 3 1 12
2YIE_X - 0.36 0.33 0.40 4 1368 6 2 4 0 8
2YIE_Z - -0.01 0.00 0.00 0 1529 11 3 8 0 12
2ZY6_A - 0.58 0.58 0.58 7 691 5 1 4 0 5
2ZZM_B 0.21 0.19 0.24 6 3461 19 0 19 0 26
2ZZN_D 0.86 0.78 0.95 21 2463 1 0 1 0 6
3A2K_C 0.84 0.71 1.00 20 2906 0 0 0 0 8
3A3A_A 0.85 0.73 1.00 27 3628 0 0 0 0 10
3ADB_C - 0.89 0.79 1.00 30 4156 0 0 0 0 8
3AKZ_H 0.67 0.57 0.80 16 2681 5 1 3 1 12
3AM1_B - 0.84 0.71 1.00 25 3215 0 0 0 0 10
3AMU_B 0.64 0.56 0.75 15 2983 7 0 5 2 12
3DW4_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
3G4S_9 0.30 0.23 0.39 13 7348 20 1 19 0 44
3GCA_A - 0.54 0.29 1.00 5 523 0 0 0 0 12
3GX2_A 0.50 0.40 0.64 16 4346 10 0 9 1 24
3HAY_E - 0.91 0.83 1.00 15 2263 3 0 0 3 3
3HJW_D - 0.51 0.50 0.53 9 1636 8 0 8 0 9
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3ID5_D - 0.44 0.33 0.60 3 491 4 0 2 2 6
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IWN_A 0.27 0.21 0.35 7 4258 13 1 12 0 26
3IYQ_A 0.29 0.29 0.29 27 60634 71 13 52 6 67
3IZ4_A 0.36 0.31 0.43 41 70780 59 7 48 4 91
3IZF_C 0.69 0.56 0.86 30 6868 5 0 5 0 24
3J0L_1 - 0.28 0.21 0.40 4 1215 6 1 5 0 15
3J0L_2 - 0.38 0.36 0.41 12 6187 18 3 14 1 21
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_8 - 0.70 0.50 1.00 4 186 0 0 0 0 4
3J0L_a - 0.39 0.31 0.50 5 1118 5 2 3 0 11
3J0L_7 - 0.51 0.41 0.64 7 1214 4 0 4 0 10
3J0L_h - 0.38 0.28 0.52 12 6082 11 0 11 0 31
3J16_L 0.82 0.67 1.00 20 2755 0 0 0 0 10
3J20_1 0.71 0.70 0.73 16 2904 6 0 6 0 7
3J20_0 0.84 0.70 1.00 21 2829 1 0 0 1 9
3J2C_O - 0.30 0.24 0.39 15 10258 24 0 23 1 48
3J2L_3 0.57 0.45 0.73 24 7842 12 1 8 3 29
3JYV_7 -0.01 0.00 0.00 0 2831 19 0 19 0 32
3JYX_3 0.60 0.56 0.65 15 6305 11 4 4 3 12
3JYX_4 0.10 0.09 0.12 3 12220 33 2 21 10 30
3KTW_C - 0.36 0.28 0.48 12 4535 13 3 10 0 31
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.28 0.23 0.35 14 9140 26 0 26 0 47
3NKB_B - 0.59 0.54 0.67 14 1995 7 0 7 0 12
3NMU_E - 0.41 0.17 1.00 1 560 3 0 0 3 5
3NPB_A 0.61 0.50 0.74 23 6990 9 0 8 1 23
3O58_3 0.09 0.09 0.10 3 12373 35 5 22 8 32
3O58_2 0.47 0.42 0.53 16 7230 16 3 11 2 22
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.57 0.44 0.74 32 12837 13 0 11 2 40
3R4F_A - 0.94 0.88 1.00 22 2123 0 0 0 0 3
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.19 0.17 0.24 7 3887 22 1 21 0 35
3SIU_F - 0.73 0.55 1.00 6 372 0 0 0 0 5
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.38 0.32 0.46 12 3134 14 0 14 0 25
3UZL_B 0.53 0.41 0.71 15 3549 6 1 5 0 22
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.67 0.58 0.79 23 4724 7 0 6 1 17
3ZEX_D 0.55 0.45 0.69 22 6989 10 0 10 0 27
3ZEX_G - 0.30 0.23 0.39 17 16427 27 2 25 0 57
3ZEX_E - 0.08 0.06 0.11 5 21900 40 1 39 0 72
4A1C_3 0.26 0.22 0.32 12 7103 25 2 23 0 42
4A1C_2 0.28 0.24 0.33 8 11757 28 0 16 12 25
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.42 0.33 0.54 14 4345 13 1 11 1 28
4ATO_G - 0.32 0.30 0.38 3 520 5 1 4 0 7
4ENB_A 0.76 0.58 1.00 11 1264 0 0 0 0 8
4ENC_A 0.69 0.47 1.00 9 1317 0 0 0 0 10
4FRG_B 0.56 0.47 0.68 15 3464 7 1 6 0 17
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.