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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(20) - scored higher in this pairwise comparison

  4. Performance of Afold - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(20) & Afold [.zip] - may take several seconds...


Overview

Metric TurboFold(20) Afold
MCC 0.646 > 0.611
Average MCC ± 95% Confidence Intervals 0.661 ± 0.354 > 0.655 ± 0.383
Sensitivity 0.535 < 0.548
Positive Predictive Value 0.783 > 0.685
Total TP 83 < 85
Total TN 23172 > 23154
Total FP 32 < 51
Total FP CONTRA 0 < 6
Total FP INCONS 23 < 33
Total FP COMP 9 < 12
Total FN 72 > 70
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(20) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(20) and Afold).

  2. Comparison of performance of TurboFold(20) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(20) and Afold).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(20) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(20) and Afold).

  4. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(20) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(20) and Afold).

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Performance of TurboFold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 83
Total TN 23172
Total FP 32
Total FP CONTRA 0
Total FP INCONS 23
Total FP COMP 9
Total FN 72
Total Scores
MCC 0.646
Average MCC ± 95% Confidence Intervals 0.661 ± 0.354
Sensitivity 0.535
Positive Predictive Value 0.783
Nr of predictions 5

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.92 0.90 0.95 18 971 1 0 1 0 2
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3ZEX_D 0.76 0.63 0.91 31 6987 3 0 3 0 18
4A1C_2 0.18 0.15 0.21 5 11757 28 0 19 9 28
4ENB_A 0.69 0.47 1.00 9 1266 0 0 0 0 10

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Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 85
Total TN 23154
Total FP 51
Total FP CONTRA 6
Total FP INCONS 33
Total FP COMP 12
Total FN 70
Total Scores
MCC 0.611
Average MCC ± 95% Confidence Intervals 0.655 ± 0.383
Sensitivity 0.548
Positive Predictive Value 0.685
Nr of predictions 5

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3ZEX_D 0.72 0.61 0.86 30 6986 5 0 5 0 19
4A1C_2 0.14 0.15 0.14 5 11745 43 5 26 12 28
4ENB_A 0.67 0.58 0.79 11 1261 3 1 2 0 8

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.