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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(seed) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(seed) & NanoFolder [.zip] - may take several seconds...


Overview

Metric TurboFold(seed) NanoFolder
MCC 0.439 > 0.341
Average MCC ± 95% Confidence Intervals 0.407 ± 0.394 > 0.379 ± 0.289
Sensitivity 0.369 > 0.351
Positive Predictive Value 0.530 > 0.339
Total TP 62 > 59
Total TN 26041 > 25984
Total FP 65 < 125
Total FP CONTRA 7 < 15
Total FP INCONS 48 < 100
Total FP COMP 10 = 10
Total FN 106 < 109
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(seed) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and NanoFolder).

  2. Comparison of performance of TurboFold(seed) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and NanoFolder).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and NanoFolder).

  4. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and NanoFolder).

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Performance of TurboFold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 62
Total TN 26041
Total FP 65
Total FP CONTRA 7
Total FP INCONS 48
Total FP COMP 10
Total FN 106
Total Scores
MCC 0.439
Average MCC ± 95% Confidence Intervals 0.407 ± 0.394
Sensitivity 0.369
Positive Predictive Value 0.530
Nr of predictions 5

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
4A1C_2 0.15 0.15 0.15 5 11748 37 3 25 9 28
4A1C_3 0.69 0.57 0.84 31 7103 6 0 6 0 23
4AOB_A 0.56 0.40 0.77 17 4349 6 1 4 1 25
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 59
Total TN 25984
Total FP 125
Total FP CONTRA 15
Total FP INCONS 100
Total FP COMP 10
Total FN 109
Total Scores
MCC 0.341
Average MCC ± 95% Confidence Intervals 0.379 ± 0.289
Sensitivity 0.351
Positive Predictive Value 0.339
Nr of predictions 5

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.52 0.55 0.50 11 1518 11 0 11 0 9
4A1C_2 0.00 0.00 0.00 0 11728 61 12 41 8 33
4A1C_3 0.48 0.46 0.51 25 7091 24 2 22 0 29
4AOB_A 0.33 0.29 0.39 12 4340 20 1 18 1 30
4ENC_A 0.57 0.58 0.58 11 1307 9 0 8 1 8

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.