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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Vsfold4 - scored higher in this pairwise comparison

  4. Performance of CMfinder(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Vsfold4 & CMfinder(20) [.zip] - may take several seconds...


Overview

Metric Vsfold4 CMfinder(20)
MCC 0.614 > 0.546
Average MCC ± 95% Confidence Intervals 0.631 ± 0.218 > 0.560 ± 0.222
Sensitivity 0.500 > 0.366
Positive Predictive Value 0.759 < 0.822
Total TP 82 > 60
Total TN 21124 < 21159
Total FP 30 > 15
Total FP CONTRA 2 > 1
Total FP INCONS 24 > 12
Total FP COMP 4 > 2
Total FN 82 < 104
P-value 0.0

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Performance plots


  1. Comparison of performance of Vsfold4 and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold4 and CMfinder(20)).

  2. Comparison of performance of Vsfold4 and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold4 and CMfinder(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold4 and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold4 and CMfinder(20)).

  4. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold4 and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold4 and CMfinder(20)).

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Performance of Vsfold4 - scored higher in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 82
Total TN 21124
Total FP 30
Total FP CONTRA 2
Total FP INCONS 24
Total FP COMP 4
Total FN 82
Total Scores
MCC 0.614
Average MCC ± 95% Confidence Intervals 0.631 ± 0.218
Sensitivity 0.500
Positive Predictive Value 0.759
Nr of predictions 4

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.84 0.70 1.00 21 2829 1 0 0 1 9
3J2L_3 0.57 0.45 0.73 24 7842 12 1 8 3 29
3ZEX_D 0.55 0.45 0.69 22 6989 10 0 10 0 27
4FRG_B 0.56 0.47 0.68 15 3464 7 1 6 0 17

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Performance of CMfinder(20) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 60
Total TN 21159
Total FP 15
Total FP CONTRA 1
Total FP INCONS 12
Total FP COMP 2
Total FN 104
Total Scores
MCC 0.546
Average MCC ± 95% Confidence Intervals 0.560 ± 0.222
Sensitivity 0.366
Positive Predictive Value 0.822
Nr of predictions 4

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.75 0.57 1.00 17 2833 1 0 0 1 13
3J2L_3 0.45 0.32 0.63 17 7848 11 1 9 1 36
3ZEX_D 0.58 0.39 0.86 19 6999 3 0 3 0 30
4FRG_B 0.47 0.22 1.00 7 3479 0 0 0 0 25

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.