CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Vsfold4 - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Vsfold4 & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric Vsfold4 Carnac(seed)
MCC 0.538 > 0.251
Average MCC ± 95% Confidence Intervals 0.580 ± 0.114 > 0.150 ± 0.109
Sensitivity 0.458 > 0.063
Positive Predictive Value 0.637 < 1.000
Total TP 471 > 65
Total TN 139930 < 140604
Total FP 311 > 0
Total FP CONTRA 28 > 0
Total FP INCONS 240 > 0
Total FP COMP 43 > 0
Total FN 557 < 963
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of Vsfold4 and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold4 and Carnac(seed)).

  2. Comparison of performance of Vsfold4 and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold4 and Carnac(seed)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Vsfold4 and Carnac(seed)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Vsfold4 and Carnac(seed)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold4 and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold4 and Carnac(seed)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold4 and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold4 and Carnac(seed)).

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Performance of Vsfold4 - scored higher in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 471
Total TN 139930
Total FP 311
Total FP CONTRA 28
Total FP INCONS 240
Total FP COMP 43
Total FN 557
Total Scores
MCC 0.538
Average MCC ± 95% Confidence Intervals 0.580 ± 0.114
Sensitivity 0.458
Positive Predictive Value 0.637
Nr of predictions 32

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2L1F_A 0.66 0.54 0.81 13 2064 3 0 3 0 11
2L1F_B 0.68 0.56 0.82 14 2128 3 0 3 0 11
2L94_A 0.92 0.85 1.00 17 973 0 0 0 0 3
2LC8_A -0.01 0.00 0.00 0 1527 13 0 13 0 20
2XKV_B -0.01 0.00 0.00 0 4533 27 8 19 0 20
2XXA_G -0.01 0.00 0.00 0 5122 29 1 28 0 42
3A3A_A 0.85 0.73 1.00 27 3628 0 0 0 0 10
3GX2_A 0.50 0.40 0.64 16 4346 10 0 9 1 24
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IZF_C 0.69 0.56 0.86 30 6868 5 0 5 0 24
3JYX_4 0.10 0.09 0.12 3 12220 33 2 21 10 30
3JYX_3 0.60 0.56 0.65 15 6305 11 4 4 3 12
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NPB_A 0.61 0.50 0.74 23 6990 9 0 8 1 23
3O58_2 0.47 0.42 0.53 16 7230 16 3 11 2 22
3O58_3 0.09 0.09 0.10 3 12373 35 5 22 8 32
3PDR_A 0.57 0.44 0.74 32 12837 13 0 11 2 40
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.19 0.17 0.24 7 3887 22 1 21 0 35
3W3S_B 0.67 0.58 0.79 23 4724 7 0 6 1 17
4A1C_3 0.26 0.22 0.32 12 7103 25 2 23 0 42
4A1C_2 0.28 0.24 0.33 8 11757 28 0 16 12 25
4AOB_A 0.42 0.33 0.54 14 4345 13 1 11 1 28
4ENB_A 0.76 0.58 1.00 11 1264 0 0 0 0 8
4ENC_A 0.69 0.47 1.00 9 1317 0 0 0 0 10
4FRG_B 0.56 0.47 0.68 15 3464 7 1 6 0 17

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 65
Total TN 140604
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 963
Total Scores
MCC 0.251
Average MCC ± 95% Confidence Intervals 0.150 ± 0.109
Sensitivity 0.063
Positive Predictive Value 1.000
Nr of predictions 32

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.00 0.00 0.00 0 1128 0 0 0 0 19
2KUR_A 0.57 0.33 1.00 7 1121 0 0 0 0 14
2KUU_A 0.57 0.33 1.00 7 1121 0 0 0 0 14
2KUV_A 0.64 0.41 1.00 9 1119 0 0 0 0 13
2KUW_A 0.65 0.43 1.00 9 1119 0 0 0 0 12
2L1F_A 0.00 0.00 0.00 0 2080 0 0 0 0 24
2L1F_B 0.00 0.00 0.00 0 2145 0 0 0 0 25
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LC8_A 0.44 0.20 1.00 4 1536 0 0 0 0 16
2XKV_B 0.00 0.00 0.00 0 4560 0 0 0 0 20
2XXA_G 0.00 0.00 0.00 0 5151 0 0 0 0 42
3A3A_A 0.00 0.00 0.00 0 3655 0 0 0 0 37
3GX2_A 0.00 0.00 0.00 0 4371 0 0 0 0 40
3IVN_B 0.00 0.00 0.00 0 2346 0 0 0 0 31
3IZF_C 0.00 0.00 0.00 0 6903 0 0 0 0 54
3JYX_4 0.00 0.00 0.00 0 12246 0 0 0 0 33
3JYX_3 0.00 0.00 0.00 0 6328 0 0 0 0 27
3LA5_A 0.00 0.00 0.00 0 2485 0 0 0 0 34
3NPB_A 0.00 0.00 0.00 0 7021 0 0 0 0 46
3O58_2 0.00 0.00 0.00 0 7260 0 0 0 0 38
3O58_3 0.00 0.00 0.00 0 12403 0 0 0 0 35
3PDR_A 0.00 0.00 0.00 0 12880 0 0 0 0 72
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
3W3S_B 0.00 0.00 0.00 0 4753 0 0 0 0 40
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.