CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	Afold		RNAwolf
MCC	0.394	>	0.281
Average MCC ± 95% Confidence Intervals	0.477 ± 0.156	>	0.421 ± 0.209
Sensitivity	0.429	>	0.293
Positive Predictive Value	0.363	>	0.271
Total TP	227	>	155
Total TN	434501	<	434554
Total FP	475	>	467
Total FP CONTRA	107	<	125
Total FP INCONS	292	<	293
Total FP COMP	76	>	49
Total FN	302	<	374
P-value	1.87872347734e-08

Comparison of performance of Afold and RNAwolf. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and RNAwolf).
Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and RNAwolf. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and RNAwolf).

Total Scores
MCC	0.394
Average MCC ± 95% Confidence Intervals	0.477 ± 0.156
Sensitivity	0.429
Positive Predictive Value	0.363
Nr of predictions	11

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
2LC8_A	GP_knot1 links to Rfam database...	0.64	0.61	0.69	11	512	6	0	5	1	7
2M58_A	-	0.40	0.42	0.42	5	532	8	1	6	1	7
3J3E_8	5_8S_rRNA links to Rfam database...	0.26	0.33	0.21	5	2718	31	6	13	12	10
3RKF_A	Purine links to Rfam database...	0.91	0.83	1.00	20	846	0	0	0	0	4
3U4M_B	-	0.49	0.55	0.46	12	1250	14	3	11	0	10
3W3S_B	tRNA-Sec links to Rfam database...	0.55	0.55	0.56	18	1957	15	4	10	1	15
3ZEX_B	-	0.34	0.38	0.31	132	420926	337	77	217	43	214
4A1C_2	5_8S_rRNA links to Rfam database...	0.19	0.25	0.15	5	4483	43	11	17	15	15
4ATO_G	-	0.38	0.43	0.38	3	212	6	5	0	1	4
4ENB_A	crcB links to Rfam database...	0.81	0.73	0.92	11	460	3	0	1	2	4
4JRC_A	-	0.27	0.29	0.29	5	605	12	0	12	0	12

Total Scores
MCC	0.281
Average MCC ± 95% Confidence Intervals	0.421 ± 0.209
Sensitivity	0.293
Positive Predictive Value	0.271
Nr of predictions	11

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
2LC8_A	GP_knot1 links to Rfam database...	0.52	0.50	0.56	9	512	7	0	7	0	9
2M58_A	-	0.60	0.58	0.64	7	533	4	1	3	0	5
3J3E_8	5_8S_rRNA links to Rfam database...	-0.01	0.00	0.00	0	2719	37	6	17	14	15
3RKF_A	Purine links to Rfam database...	0.89	0.83	0.95	20	845	1	0	1	0	4
3U4M_B	-	0.50	0.50	0.52	11	1255	12	1	9	2	11
3W3S_B	tRNA-Sec links to Rfam database...	0.70	0.70	0.72	23	1957	10	0	9	1	10
3ZEX_B	-	0.18	0.19	0.17	65	420964	343	98	225	20	281
4A1C_2	5_8S_rRNA links to Rfam database...	0.12	0.15	0.10	3	4487	38	12	14	12	17
4ATO_G	-	-0.03	0.00	0.00	0	213	7	4	3	0	7
4ENB_A	crcB links to Rfam database...	0.45	0.40	0.55	6	461	5	1	4	0	9
4JRC_A	-	0.71	0.65	0.79	11	608	3	2	1	0	6

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.