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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Afold - scored higher in this pairwise comparison

  4. Performance of TurboFold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Afold & TurboFold(seed) [.zip] - may take several seconds...


Overview

Metric Afold TurboFold(seed)
MCC 0.524 > 0.409
Average MCC ± 95% Confidence Intervals 0.562 ± 0.403 > 0.424 ± 0.496
Sensitivity 0.565 > 0.424
Positive Predictive Value 0.495 > 0.406
Total TP 52 > 39
Total TN 9019 < 9028
Total FP 83 > 80
Total FP CONTRA 17 < 18
Total FP INCONS 36 < 39
Total FP COMP 30 > 23
Total FN 40 < 53
P-value 0.0

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Performance plots


  1. Comparison of performance of Afold and TurboFold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and TurboFold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and TurboFold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and TurboFold(seed)).

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Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 52
Total TN 9019
Total FP 83
Total FP CONTRA 17
Total FP INCONS 36
Total FP COMP 30
Total FN 40
Total Scores
MCC 0.524
Average MCC ± 95% Confidence Intervals 0.562 ± 0.403
Sensitivity 0.565
Positive Predictive Value 0.495
Nr of predictions 5

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.64 0.61 0.69 11 512 6 0 5 1 7
3J3E_8 0.26 0.33 0.21 5 2718 31 6 13 12 10
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
4A1C_2 0.19 0.25 0.15 5 4483 43 11 17 15 15
4ENB_A 0.81 0.73 0.92 11 460 3 0 1 2 4

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Performance of TurboFold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 39
Total TN 9028
Total FP 80
Total FP CONTRA 18
Total FP INCONS 39
Total FP COMP 23
Total FN 53
Total Scores
MCC 0.409
Average MCC ± 95% Confidence Intervals 0.424 ± 0.496
Sensitivity 0.424
Positive Predictive Value 0.406
Nr of predictions 5

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
3J3E_8 0.27 0.33 0.23 5 2720 28 6 11 11 10
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
4A1C_2 0.20 0.25 0.17 5 4486 37 9 16 12 15
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.