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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Alterna - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Alterna & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric Alterna Multilign(seed)
MCC 0.624 > 0.589
Average MCC ± 95% Confidence Intervals 0.615 ± 0.457 > 0.515 ± 1.207
Sensitivity 0.606 > 0.549
Positive Predictive Value 0.662 > 0.650
Total TP 43 > 39
Total TN 2862 < 2867
Total FP 22 > 21
Total FP CONTRA 5 < 6
Total FP INCONS 17 > 15
Total FP COMP 0 = 0
Total FN 28 < 32
P-value 0.0

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Performance plots


  1. Comparison of performance of Alterna and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Alterna and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Alterna and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Alterna and Multilign(seed)).

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Performance of Alterna - scored higher in this pairwise comparison

1. Total counts & total scores for Alterna

Total Base Pair Counts
Total TP 43
Total TN 2862
Total FP 22
Total FP CONTRA 5
Total FP INCONS 17
Total FP COMP 0
Total FN 28
Total Scores
MCC 0.624
Average MCC ± 95% Confidence Intervals 0.615 ± 0.457
Sensitivity 0.606
Positive Predictive Value 0.662
Nr of predictions 3

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2. Individual counts for Alterna [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.47 0.44 0.53 8 513 7 0 7 0 10
3RKF_A 0.82 0.79 0.86 19 844 3 1 2 0 5
3SD1_A 0.55 0.55 0.57 16 1505 12 4 8 0 13

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 39
Total TN 2867
Total FP 21
Total FP CONTRA 6
Total FP INCONS 15
Total FP COMP 0
Total FN 32
Total Scores
MCC 0.589
Average MCC ± 95% Confidence Intervals 0.515 ± 1.207
Sensitivity 0.549
Positive Predictive Value 0.650
Nr of predictions 3

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.