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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CMfinder(20) - scored higher in this pairwise comparison

  4. Performance of CentroidFold - scored lower in this pairwise comparison

  5. Compile and download dataset for CMfinder(20) & CentroidFold [.zip] - may take several seconds...


Overview

Metric CMfinder(20) CentroidFold
MCC 0.580 > 0.516
Average MCC ± 95% Confidence Intervals 0.564 ± 0.352 > 0.501 ± 0.327
Sensitivity 0.500 < 0.561
Positive Predictive Value 0.681 > 0.482
Total TP 49 < 55
Total TN 10820 > 10778
Total FP 26 < 82
Total FP CONTRA 12 < 25
Total FP INCONS 11 < 34
Total FP COMP 3 < 23
Total FN 49 > 43
P-value 0.0

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Performance plots


  1. Comparison of performance of CMfinder(20) and CentroidFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(20) and CentroidFold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(20) and CentroidFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(20) and CentroidFold).

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Performance of CMfinder(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 49
Total TN 10820
Total FP 26
Total FP CONTRA 12
Total FP INCONS 11
Total FP COMP 3
Total FN 49
Total Scores
MCC 0.580
Average MCC ± 95% Confidence Intervals 0.564 ± 0.352
Sensitivity 0.500
Positive Predictive Value 0.681
Nr of predictions 5

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.84 0.76 0.94 16 1202 2 1 0 1 5
3J3D_C 0.81 0.79 0.83 15 950 3 3 0 0 4
3J3E_8 0.14 0.13 0.17 2 2730 10 3 7 0 13
3J3F_8 0.48 0.47 0.50 9 4743 11 5 4 2 10
4FRG_B 0.54 0.29 1.00 7 1195 0 0 0 0 17

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Performance of CentroidFold - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidFold

Total Base Pair Counts
Total TP 55
Total TN 10778
Total FP 82
Total FP CONTRA 25
Total FP INCONS 34
Total FP COMP 23
Total FN 43
Total Scores
MCC 0.516
Average MCC ± 95% Confidence Intervals 0.501 ± 0.327
Sensitivity 0.561
Positive Predictive Value 0.482
Nr of predictions 5

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2. Individual counts for CentroidFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.54 0.57 0.52 12 1196 12 3 8 1 9
3J3D_C 0.73 0.79 0.68 15 946 7 3 4 0 4
3J3E_8 0.12 0.13 0.13 2 2726 22 4 10 8 13
3J3F_8 0.36 0.47 0.28 9 4729 37 12 11 14 10
4FRG_B 0.75 0.71 0.81 17 1181 4 3 1 0 7

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.