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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CMfinder(20) - scored higher in this pairwise comparison

  4. Performance of MaxExpect - scored lower in this pairwise comparison

  5. Compile and download dataset for CMfinder(20) & MaxExpect [.zip] - may take several seconds...


Overview

Metric CMfinder(20) MaxExpect
MCC 0.580 > 0.352
Average MCC ± 95% Confidence Intervals 0.564 ± 0.352 > 0.345 ± 0.206
Sensitivity 0.500 > 0.388
Positive Predictive Value 0.681 > 0.330
Total TP 49 > 38
Total TN 10820 > 10777
Total FP 26 < 108
Total FP CONTRA 12 < 26
Total FP INCONS 11 < 51
Total FP COMP 3 < 31
Total FN 49 < 60
P-value 0.0

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Performance plots


  1. Comparison of performance of CMfinder(20) and MaxExpect. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(20) and MaxExpect).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(20) and MaxExpect. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(20) and MaxExpect).

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Performance of CMfinder(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 49
Total TN 10820
Total FP 26
Total FP CONTRA 12
Total FP INCONS 11
Total FP COMP 3
Total FN 49
Total Scores
MCC 0.580
Average MCC ± 95% Confidence Intervals 0.564 ± 0.352
Sensitivity 0.500
Positive Predictive Value 0.681
Nr of predictions 5

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.84 0.76 0.94 16 1202 2 1 0 1 5
3J3D_C 0.81 0.79 0.83 15 950 3 3 0 0 4
3J3E_8 0.14 0.13 0.17 2 2730 10 3 7 0 13
3J3F_8 0.48 0.47 0.50 9 4743 11 5 4 2 10
4FRG_B 0.54 0.29 1.00 7 1195 0 0 0 0 17

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Performance of MaxExpect - scored lower in this pairwise comparison

1. Total counts & total scores for MaxExpect

Total Base Pair Counts
Total TP 38
Total TN 10777
Total FP 108
Total FP CONTRA 26
Total FP INCONS 51
Total FP COMP 31
Total FN 60
Total Scores
MCC 0.352
Average MCC ± 95% Confidence Intervals 0.345 ± 0.206
Sensitivity 0.388
Positive Predictive Value 0.330
Nr of predictions 5

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2. Individual counts for MaxExpect [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.53 0.57 0.50 12 1195 13 2 10 1 9
3J3D_C 0.47 0.53 0.43 10 945 13 5 8 0 9
3J3E_8 0.10 0.13 0.09 2 2719 32 5 16 11 13
3J3F_8 0.34 0.42 0.29 8 4733 39 10 10 19 11
4FRG_B 0.29 0.25 0.35 6 1185 11 4 7 0 18

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.