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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CMfinder(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for CMfinder(20) & Multilign(20) [.zip] - may take several seconds...


Overview

Metric CMfinder(20) Multilign(20)
MCC 0.580 > 0.438
Average MCC ± 95% Confidence Intervals 0.564 ± 0.352 > 0.429 ± 0.465
Sensitivity 0.500 > 0.469
Positive Predictive Value 0.681 > 0.418
Total TP 49 > 46
Total TN 10820 > 10782
Total FP 26 < 79
Total FP CONTRA 12 < 22
Total FP INCONS 11 < 42
Total FP COMP 3 < 15
Total FN 49 < 52
P-value 0.0

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Performance plots


  1. Comparison of performance of CMfinder(20) and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(20) and Multilign(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(20) and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(20) and Multilign(20)).

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Performance of CMfinder(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 49
Total TN 10820
Total FP 26
Total FP CONTRA 12
Total FP INCONS 11
Total FP COMP 3
Total FN 49
Total Scores
MCC 0.580
Average MCC ± 95% Confidence Intervals 0.564 ± 0.352
Sensitivity 0.500
Positive Predictive Value 0.681
Nr of predictions 5

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.84 0.76 0.94 16 1202 2 1 0 1 5
3J3D_C 0.81 0.79 0.83 15 950 3 3 0 0 4
3J3E_8 0.14 0.13 0.17 2 2730 10 3 7 0 13
3J3F_8 0.48 0.47 0.50 9 4743 11 5 4 2 10
4FRG_B 0.54 0.29 1.00 7 1195 0 0 0 0 17

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 46
Total TN 10782
Total FP 79
Total FP CONTRA 22
Total FP INCONS 42
Total FP COMP 15
Total FN 52
Total Scores
MCC 0.438
Average MCC ± 95% Confidence Intervals 0.429 ± 0.465
Sensitivity 0.469
Positive Predictive Value 0.418
Nr of predictions 5

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.68 0.71 0.65 15 1196 9 2 6 1 6
3J3D_C 0.90 0.95 0.86 18 947 3 3 0 0 1
3J3E_8 -0.01 0.00 0.00 0 2720 22 8 14 0 15
3J3F_8 0.45 0.53 0.38 10 4735 30 7 9 14 9
4FRG_B 0.13 0.13 0.17 3 1184 15 2 13 0 21

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.