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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CMfinder(20) - scored higher in this pairwise comparison

  4. Performance of Murlet(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CMfinder(20) & Murlet(seed) [.zip] - may take several seconds...


Overview

Metric CMfinder(20) Murlet(seed)
MCC 0.385 > 0.341
Average MCC ± 95% Confidence Intervals 0.389 ± 0.528 > 0.379 ± 0.548
Sensitivity 0.310 > 0.207
Positive Predictive Value 0.486 < 0.571
Total TP 18 > 12
Total TN 8668 < 8684
Total FP 21 > 11
Total FP CONTRA 8 > 0
Total FP INCONS 11 > 9
Total FP COMP 2 = 2
Total FN 40 < 46
P-value 0.0

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Performance plots


  1. Comparison of performance of CMfinder(20) and Murlet(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(20) and Murlet(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(20) and Murlet(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(20) and Murlet(seed)).

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Performance of CMfinder(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 18
Total TN 8668
Total FP 21
Total FP CONTRA 8
Total FP INCONS 11
Total FP COMP 2
Total FN 40
Total Scores
MCC 0.385
Average MCC ± 95% Confidence Intervals 0.389 ± 0.528
Sensitivity 0.310
Positive Predictive Value 0.486
Nr of predictions 3

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.14 0.13 0.17 2 2730 10 3 7 0 13
3J3F_8 0.48 0.47 0.50 9 4743 11 5 4 2 10
4FRG_B 0.54 0.29 1.00 7 1195 0 0 0 0 17

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Performance of Murlet(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 12
Total TN 8684
Total FP 11
Total FP CONTRA 0
Total FP INCONS 9
Total FP COMP 2
Total FN 46
Total Scores
MCC 0.341
Average MCC ± 95% Confidence Intervals 0.379 ± 0.548
Sensitivity 0.207
Positive Predictive Value 0.571
Nr of predictions 3

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.36 0.13 1.00 2 2740 2 0 0 2 13
3J3F_8 0.61 0.37 1.00 7 4754 0 0 0 0 12
4FRG_B 0.17 0.13 0.25 3 1190 9 0 9 0 21

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.