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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CMfinder(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for CMfinder(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric CMfinder(20) NanoFolder
MCC 0.513 > 0.346
Average MCC ± 95% Confidence Intervals 0.479 ± 0.823 > 0.350 ± 0.963
Sensitivity 0.491 < 0.509
Positive Predictive Value 0.542 > 0.243
Total TP 26 < 27
Total TN 8423 > 8360
Total FP 24 < 115
Total FP CONTRA 11 < 41
Total FP INCONS 11 < 43
Total FP COMP 2 < 31
Total FN 27 > 26
P-value 0.0

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Performance plots


  1. Comparison of performance of CMfinder(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(20) and NanoFolder).

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Performance of CMfinder(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 26
Total TN 8423
Total FP 24
Total FP CONTRA 11
Total FP INCONS 11
Total FP COMP 2
Total FN 27
Total Scores
MCC 0.513
Average MCC ± 95% Confidence Intervals 0.479 ± 0.823
Sensitivity 0.491
Positive Predictive Value 0.542
Nr of predictions 3

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3D_C 0.81 0.79 0.83 15 950 3 3 0 0 4
3J3E_8 0.14 0.13 0.17 2 2730 10 3 7 0 13
3J3F_8 0.48 0.47 0.50 9 4743 11 5 4 2 10

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 27
Total TN 8360
Total FP 115
Total FP CONTRA 41
Total FP INCONS 43
Total FP COMP 31
Total FN 26
Total Scores
MCC 0.346
Average MCC ± 95% Confidence Intervals 0.350 ± 0.963
Sensitivity 0.509
Positive Predictive Value 0.243
Nr of predictions 3

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3D_C 0.76 0.95 0.62 18 939 11 9 2 0 1
3J3E_8 -0.01 0.00 0.00 0 2707 47 11 24 12 15
3J3F_8 0.30 0.47 0.19 9 4714 57 21 17 19 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.