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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CMfinder(20) - scored higher in this pairwise comparison

  4. Performance of RNAfold - scored lower in this pairwise comparison

  5. Compile and download dataset for CMfinder(20) & RNAfold [.zip] - may take several seconds...


Overview

Metric CMfinder(20) RNAfold
MCC 0.580 > 0.363
Average MCC ± 95% Confidence Intervals 0.564 ± 0.352 > 0.358 ± 0.120
Sensitivity 0.500 > 0.418
Positive Predictive Value 0.681 > 0.325
Total TP 49 > 41
Total TN 10820 > 10766
Total FP 26 < 117
Total FP CONTRA 12 < 25
Total FP INCONS 11 < 60
Total FP COMP 3 < 32
Total FN 49 < 57
P-value 0.0

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Performance plots


  1. Comparison of performance of CMfinder(20) and RNAfold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(20) and RNAfold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(20) and RNAfold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(20) and RNAfold).

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Performance of CMfinder(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 49
Total TN 10820
Total FP 26
Total FP CONTRA 12
Total FP INCONS 11
Total FP COMP 3
Total FN 49
Total Scores
MCC 0.580
Average MCC ± 95% Confidence Intervals 0.564 ± 0.352
Sensitivity 0.500
Positive Predictive Value 0.681
Nr of predictions 5

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.84 0.76 0.94 16 1202 2 1 0 1 5
3J3D_C 0.81 0.79 0.83 15 950 3 3 0 0 4
3J3E_8 0.14 0.13 0.17 2 2730 10 3 7 0 13
3J3F_8 0.48 0.47 0.50 9 4743 11 5 4 2 10
4FRG_B 0.54 0.29 1.00 7 1195 0 0 0 0 17

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Performance of RNAfold - scored lower in this pairwise comparison

1. Total counts & total scores for RNAfold

Total Base Pair Counts
Total TP 41
Total TN 10766
Total FP 117
Total FP CONTRA 25
Total FP INCONS 60
Total FP COMP 32
Total FN 57
Total Scores
MCC 0.363
Average MCC ± 95% Confidence Intervals 0.358 ± 0.120
Sensitivity 0.418
Positive Predictive Value 0.325
Nr of predictions 5

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2. Individual counts for RNAfold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.51 0.57 0.48 12 1194 14 3 10 1 9
3J3D_C 0.33 0.37 0.32 7 946 15 3 12 0 12
3J3E_8 0.25 0.33 0.20 5 2717 31 7 13 11 10
3J3F_8 0.33 0.42 0.27 8 4731 42 10 12 20 11
4FRG_B 0.36 0.38 0.38 9 1178 15 2 13 0 15

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.