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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CMfinder(20) - scored higher in this pairwise comparison

  4. Performance of Sfold - scored lower in this pairwise comparison

  5. Compile and download dataset for CMfinder(20) & Sfold [.zip] - may take several seconds...


Overview

Metric CMfinder(20) Sfold
MCC 0.580 > 0.424
Average MCC ± 95% Confidence Intervals 0.564 ± 0.352 > 0.423 ± 0.259
Sensitivity 0.500 > 0.449
Positive Predictive Value 0.681 > 0.411
Total TP 49 > 44
Total TN 10820 > 10785
Total FP 26 < 93
Total FP CONTRA 12 < 21
Total FP INCONS 11 < 42
Total FP COMP 3 < 30
Total FN 49 < 54
P-value 0.0

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Performance plots


  1. Comparison of performance of CMfinder(20) and Sfold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(20) and Sfold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(20) and Sfold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(20) and Sfold).

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Performance of CMfinder(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 49
Total TN 10820
Total FP 26
Total FP CONTRA 12
Total FP INCONS 11
Total FP COMP 3
Total FN 49
Total Scores
MCC 0.580
Average MCC ± 95% Confidence Intervals 0.564 ± 0.352
Sensitivity 0.500
Positive Predictive Value 0.681
Nr of predictions 5

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.84 0.76 0.94 16 1202 2 1 0 1 5
3J3D_C 0.81 0.79 0.83 15 950 3 3 0 0 4
3J3E_8 0.14 0.13 0.17 2 2730 10 3 7 0 13
3J3F_8 0.48 0.47 0.50 9 4743 11 5 4 2 10
4FRG_B 0.54 0.29 1.00 7 1195 0 0 0 0 17

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Performance of Sfold - scored lower in this pairwise comparison

1. Total counts & total scores for Sfold

Total Base Pair Counts
Total TP 44
Total TN 10785
Total FP 93
Total FP CONTRA 21
Total FP INCONS 42
Total FP COMP 30
Total FN 54
Total Scores
MCC 0.424
Average MCC ± 95% Confidence Intervals 0.423 ± 0.259
Sensitivity 0.449
Positive Predictive Value 0.411
Nr of predictions 5

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2. Individual counts for Sfold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.51 0.57 0.48 12 1194 14 3 10 1 9
3J3D_C 0.44 0.37 0.54 7 955 6 1 5 0 12
3J3E_8 0.10 0.13 0.08 2 2718 32 6 16 10 13
3J3F_8 0.39 0.47 0.33 9 4734 37 8 10 19 10
4FRG_B 0.67 0.58 0.78 14 1184 4 3 1 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.