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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CMfinder(20) - scored higher in this pairwise comparison

  4. Performance of UNAFold - scored lower in this pairwise comparison

  5. Compile and download dataset for CMfinder(20) & UNAFold [.zip] - may take several seconds...


Overview

Metric CMfinder(20) UNAFold
MCC 0.580 > 0.343
Average MCC ± 95% Confidence Intervals 0.564 ± 0.352 > 0.336 ± 0.160
Sensitivity 0.500 > 0.398
Positive Predictive Value 0.681 > 0.307
Total TP 49 > 39
Total TN 10820 > 10765
Total FP 26 < 120
Total FP CONTRA 12 < 26
Total FP INCONS 11 < 62
Total FP COMP 3 < 32
Total FN 49 < 59
P-value 0.0

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Performance plots


  1. Comparison of performance of CMfinder(20) and UNAFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(20) and UNAFold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(20) and UNAFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(20) and UNAFold).

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Performance of CMfinder(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 49
Total TN 10820
Total FP 26
Total FP CONTRA 12
Total FP INCONS 11
Total FP COMP 3
Total FN 49
Total Scores
MCC 0.580
Average MCC ± 95% Confidence Intervals 0.564 ± 0.352
Sensitivity 0.500
Positive Predictive Value 0.681
Nr of predictions 5

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.84 0.76 0.94 16 1202 2 1 0 1 5
3J3D_C 0.81 0.79 0.83 15 950 3 3 0 0 4
3J3E_8 0.14 0.13 0.17 2 2730 10 3 7 0 13
3J3F_8 0.48 0.47 0.50 9 4743 11 5 4 2 10
4FRG_B 0.54 0.29 1.00 7 1195 0 0 0 0 17

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Performance of UNAFold - scored lower in this pairwise comparison

1. Total counts & total scores for UNAFold

Total Base Pair Counts
Total TP 39
Total TN 10765
Total FP 120
Total FP CONTRA 26
Total FP INCONS 62
Total FP COMP 32
Total FN 59
Total Scores
MCC 0.343
Average MCC ± 95% Confidence Intervals 0.336 ± 0.160
Sensitivity 0.398
Positive Predictive Value 0.307
Nr of predictions 5

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2. Individual counts for UNAFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.51 0.57 0.48 12 1194 14 3 10 1 9
3J3D_C 0.33 0.37 0.32 7 946 15 3 12 0 12
3J3E_8 0.15 0.20 0.13 3 2718 32 6 15 11 12
3J3F_8 0.32 0.42 0.25 8 4729 44 12 12 20 11
4FRG_B 0.36 0.38 0.38 9 1178 15 2 13 0 15

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.