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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CRWrnafold - scored higher in this pairwise comparison

  4. Performance of RSpredict(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for CRWrnafold & RSpredict(20) [.zip] - may take several seconds...


Overview

Metric CRWrnafold RSpredict(20)
MCC 0.592 > 0.494
Average MCC ± 95% Confidence Intervals 0.646 ± 0.339 > 0.487 ± 0.275
Sensitivity 0.611 > 0.454
Positive Predictive Value 0.584 > 0.551
Total TP 66 > 49
Total TN 8341 < 8365
Total FP 68 > 47
Total FP CONTRA 18 = 18
Total FP INCONS 29 > 22
Total FP COMP 21 > 7
Total FN 42 < 59
P-value 0.0

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Performance plots


  1. Comparison of performance of CRWrnafold and RSpredict(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CRWrnafold and RSpredict(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CRWrnafold and RSpredict(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CRWrnafold and RSpredict(20)).

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Performance of CRWrnafold - scored higher in this pairwise comparison

1. Total counts & total scores for CRWrnafold

Total Base Pair Counts
Total TP 66
Total TN 8341
Total FP 68
Total FP CONTRA 18
Total FP INCONS 29
Total FP COMP 21
Total FN 42
Total Scores
MCC 0.592
Average MCC ± 95% Confidence Intervals 0.646 ± 0.339
Sensitivity 0.611
Positive Predictive Value 0.584
Nr of predictions 5

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2. Individual counts for CRWrnafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3SD1_A 0.63 0.66 0.61 19 1502 12 6 6 0 10
4A1C_2 0.19 0.25 0.15 5 4483 44 8 20 16 15
4AOB_A 0.71 0.69 0.74 20 1410 8 4 3 1 9
4ENB_A 0.85 0.73 1.00 11 461 2 0 0 2 4
4ENC_A 0.85 0.73 1.00 11 485 2 0 0 2 4

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Performance of RSpredict(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(20)

Total Base Pair Counts
Total TP 49
Total TN 8365
Total FP 47
Total FP CONTRA 18
Total FP INCONS 22
Total FP COMP 7
Total FN 59
Total Scores
MCC 0.494
Average MCC ± 95% Confidence Intervals 0.487 ± 0.275
Sensitivity 0.454
Positive Predictive Value 0.551
Nr of predictions 5

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2. Individual counts for RSpredict(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3SD1_A 0.82 0.86 0.78 25 1501 7 5 2 0 4
4A1C_2 0.25 0.30 0.21 6 4487 30 12 11 7 14
4AOB_A 0.33 0.21 0.55 6 1426 5 1 4 0 23
4ENB_A 0.54 0.40 0.75 6 464 2 0 2 0 9
4ENC_A 0.51 0.40 0.67 6 487 3 0 3 0 9

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.