CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Carnac(20) - scored higher in this pairwise comparison

  4. Performance of Mastr(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Carnac(20) & Mastr(20) [.zip] - may take several seconds...


Overview

Metric Carnac(20) Mastr(20)
MCC 0.641 > 0.508
Average MCC ± 95% Confidence Intervals 0.582 ± 0.134 > 0.437 ± 0.179
Sensitivity 0.456 > 0.329
Positive Predictive Value 0.908 > 0.793
Total TP 265 > 191
Total TN 68237 < 68288
Total FP 41 < 57
Total FP CONTRA 11 < 14
Total FP INCONS 16 < 36
Total FP COMP 14 > 7
Total FN 316 < 390
P-value 5.1503931209e-08

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Performance plots


  1. Comparison of performance of Carnac(20) and Mastr(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Carnac(20) and Mastr(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Carnac(20) and Mastr(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Carnac(20) and Mastr(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Carnac(20) and Mastr(20)).

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Performance of Carnac(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 265
Total TN 68237
Total FP 41
Total FP CONTRA 11
Total FP INCONS 16
Total FP COMP 14
Total FN 316
Total Scores
MCC 0.641
Average MCC ± 95% Confidence Intervals 0.582 ± 0.134
Sensitivity 0.456
Positive Predictive Value 0.908
Nr of predictions 21

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3A2K_C 0.88 0.77 1.00 17 1091 0 0 0 0 5
3GX2_A 0.68 0.46 1.00 13 1436 0 0 0 0 15
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IZ4_A 0.52 0.31 0.88 29 25503 4 3 1 0 66
3J20_0 0.69 0.71 0.68 15 1197 8 1 6 1 6
3J3D_C 0.90 0.95 0.86 18 947 3 3 0 0 1
3J3E_8 0.00 0.00 0.00 0 2742 0 0 0 0 15
3J3F_8 0.61 0.37 1.00 7 4754 2 0 0 2 12
3JYV_7 0.81 0.70 0.93 14 1096 3 0 1 2 6
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NPB_A 0.46 0.22 1.00 8 2270 3 0 0 3 29
3O58_3 0.60 0.36 1.00 8 4756 1 0 0 1 14
3PDR_A 0.75 0.58 0.97 29 4810 3 1 0 2 21
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.72 0.55 0.94 16 1516 1 0 1 0 13
3ZEX_C 0.37 0.21 0.67 6 5365 4 1 2 1 23
4A1C_2 0.42 0.25 0.71 5 4509 3 0 2 1 15
4AOB_A 0.59 0.48 0.74 14 1418 6 2 3 1 15
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.50 0.25 1.00 6 1196 0 0 0 0 18

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Performance of Mastr(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(20)

Total Base Pair Counts
Total TP 191
Total TN 68288
Total FP 57
Total FP CONTRA 14
Total FP INCONS 36
Total FP COMP 7
Total FN 390
Total Scores
MCC 0.508
Average MCC ± 95% Confidence Intervals 0.437 ± 0.179
Sensitivity 0.329
Positive Predictive Value 0.793
Nr of predictions 21

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2. Individual counts for Mastr(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3A2K_C 0.81 0.77 0.85 17 1088 3 0 3 0 5
3GX2_A 0.46 0.39 0.55 11 1429 10 2 7 1 17
3IVN_B 0.86 0.83 0.90 19 882 2 2 0 0 4
3IZ4_A 0.00 0.00 0.00 0 25536 0 0 0 0 95
3J20_0 0.95 0.95 0.95 20 1198 2 1 0 1 1
3J3D_C 0.90 0.95 0.86 18 947 3 3 0 0 1
3J3E_8 0.00 0.00 0.00 0 2742 0 0 0 0 15
3J3F_8 0.00 0.00 0.00 0 4761 0 0 0 0 19
3JYV_7 0.97 0.95 1.00 19 1092 2 0 0 2 1
3LA5_A 0.89 0.80 1.00 20 934 0 0 0 0 5
3NPB_A 0.34 0.30 0.41 11 2251 18 1 15 2 26
3O58_3 0.00 0.00 0.00 0 4764 0 0 0 0 22
3PDR_A 0.00 0.00 0.00 0 4840 0 0 0 0 50
3RKF_A 0.84 0.71 1.00 17 849 0 0 0 0 7
3SD1_A 0.73 0.72 0.75 21 1505 7 4 3 0 8
3ZEX_C 0.00 0.00 0.00 0 5374 0 0 0 0 29
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4AOB_A 0.42 0.34 0.53 10 1418 10 1 8 1 19
4ENB_A 0.44 0.20 1.00 3 469 0 0 0 0 12
4ENC_A 0.57 0.33 1.00 5 491 0 0 0 0 10
4FRG_B 0.00 0.00 0.00 0 1202 0 0 0 0 24

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.